Flashcards in Adaptive Immune Response to Extra-cellular Pathogens - Steiner/Jones Deck (11)
Immune response to Extracellular pathogens is initiated by ___ & ____.
Macrophages & Neutrophils
_____ Drives the Antibody response.
_____ is considered the driver of Cell mediated immunity.
The Humoral Immune response involves ________.
True or false, Naive B cells produce antibodies.
False! B cells must become activated first before they can produce antibodies.
B cells can be activated by ________ & _______.
Microbes & Soluble antigens
After and Exposure to a Microbial infection, in what quantities relative to time would you expect to see Antibodies IgG and IgM?
Lots of IgM peaking at 3-5 days and then nearly double that number of IgG's peaking at 10-14 days lasting much longer.
*IgG is usually T cell dependent
IgM is usually T cell independent
B cell exposure to microbes can result in ________.
Changes in phenotype and function.
- Increased survival
- Increased expression of b7 1 &2
- Increased expression of cytokine receptors
- increased expression of CCR7 and migration from follicle to T cell areas.
B cell proliferation and differentiation occurs via a process called ______.
T cells and B cell interact in the ______.