Adaptive Immune Response to Extra-cellular Pathogens - Steiner/Jones Flashcards Preview

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Flashcards in Adaptive Immune Response to Extra-cellular Pathogens - Steiner/Jones Deck (11)
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1

Immune response to Extracellular pathogens is initiated by ___ & ____.

Macrophages & Neutrophils

2

_____ Drives the Antibody response.

Th2 immunity

3

_____ is considered the driver of Cell mediated immunity.

Th1 immunity

4

The Humoral Immune response involves ________.

Antibody production

5

True or false, Naive B cells produce antibodies.

False! B cells must become activated first before they can produce antibodies.

6

B cells can be activated by ________ & _______.

Microbes & Soluble antigens

7

After and Exposure to a Microbial infection, in what quantities relative to time would you expect to see Antibodies IgG and IgM?

Lots of IgM peaking at 3-5 days and then nearly double that number of IgG's peaking at 10-14 days lasting much longer.
*IgG is usually T cell dependent
IgM is usually T cell independent

8

B cell exposure to microbes can result in ________.

Changes in phenotype and function.

- Increased survival
-Proliferation
- Increased expression of b7 1 &2
- Increased expression of cytokine receptors
- increased expression of CCR7 and migration from follicle to T cell areas.

9

B cell proliferation and differentiation occurs via a process called ______.

Colonal Expansion

10

T cells and B cell interact in the ______.

Lymph nodes

11

Isotype/Class Switching is Dependent on _______ and ______.

T cell interactions & Cytokines