Lecture 14: Fibrous Connective Tissue Flashcards Preview

Year 1: 03. MSK Exam 1 > Lecture 14: Fibrous Connective Tissue > Flashcards

Flashcards in Lecture 14: Fibrous Connective Tissue Deck (33)
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1

What are the properties of Connective Tissue?

What cells are considered Connective Tissue?

Properties: Separated by outside environment via epithelium and from other CT cells via ECM

Cells Types

1. Fibroblasts: collagen, proteoglycans, glycoproteins

2. Mesenchymal: CT stem cells

3. Adipocytes: fat cells

4. Chondrocytes: cartilage

5. Osteoblasts: bone

6. Hematopoietic: RBC and Immune Cells

 

2

What are the functions of Connective Tissue?

1. Structural framework

2. Protection and support

3. Energy storage

4. Transport fluids, cells, and dissolved chemicals

5. Immune System Defense

3

What organelles might a plasma cell have a disporportionate volume of?

Golgi Apparatus/Rough Endoplasmic Reticulum

(It produces and exports antibodies)

4

What are the fibrous components of the ECM of connective tissue?

1. Collagen: Resists tension

2. Elastin: Stretchable Fiber

3. Reticular Fibers: supportive meshwork

5

Besides the structural, what is the function of Extracellular Matrix?

Carries O2, CO2, Nutrients, and Wastes

6

What is the most common type of collagen?

Type 1

7

What is Elastin assembled from?

Tropoelastin

Fibulin-1

Fibrillins 1 and 2

8

What can cause shallow breathing in COPD relating to connective tissue?

Elastin breakdown prevents the lungs from retracting fully to prepare for the next inhalation.

9

What makes the Extracellular Matrix in bone different from that in other tissues?

It is mineralized

10

What composes the ECM ground substance?

1. Proteoglycans (protein w/ sugar)

Ex: Chondroitin, Heparan, Keratan Sulfates

2. Hyaluronan: connects proteoglycans

3. Glycoproteins

Includes cytokines, GF, structural proteins

4. Extracellular proenzymes

11

What are Syndecans?

Strong coreceptors for growth factors on the cell membrane

12

What do integrin receptors do as a basic function?

Allow cell to extracellular matrix interaction

13

What is the name of umbillical embryonic connective tissue?

Warton's Jelly

14

What are the three types of loose connective tissue?

1. Areolar

2. Adipose

3. Reticular

15

What is the lamina propria?

Loose connective tissue beneath membranous epithelia

16

What are the fixed cells of areolar connective tissue?

Fibroblasts

Adipocytes

Mesenchymal Cells

17

What are the wandering cells of loose areolar connective tissue?

Macrophages

Mast Cells

Leukocytes / Lymphocytes

Plasma Cells

18

Where can you find adipocytes?

Under skin and organs (e.g. kidneys, eyeballs)

Within abdomen, breats, and buttocks

19

What are the 4 functions of white fat?

Energy storage, insulation, cushioning, hormone secretion

20

What are the characteristics of brown fat?

Thermogenic

Abundant in newborns

Greatly reduced in adults

Contains abundant mitochondria

21

What does reticular connective tissue do?

Forms a "chicken wire" cage to support and hold cells in place against gravity

22

What are the three types of dense connective tissue?

Dense irrregular

Dense regular

Elastic

23

Where is dense irregular connective tissue found?

Dermis of the skin

Capsules of internal organs (eg kidney)

Perichondrium and pariosteum

Fascia

24

Why might dense regular connective tissue heal slowly compared to other tissues?

It is poorly vascularized

25

Where can you find dense connective tissue?

Tendons

Ligaments

Aponeuroses

Dense fascia

Joint Capsules

26

What is the principal cell type of dense connective tissue?

Fibroblasts

27

Where might elastic connective tissue be found and what does it do?

Elastic CT: allows for recoil of tissue follwing streching

Location: Walls of large arteries

Walls of bronchiole tubes (lungs can expand collapse)

Special ligaments (eg Ligamentum Nuchae)

28

What is Ehlers-Danlos Syndrome?

A mutation in collagen synthesis and structure, leading to weak collagen fibers.

29

What does a deficiency of Vitamin C cause in connective tissue?

What is the basic mechanism?

Weakens Connective Tissue

Vitamin C is necessary for cross linking of collagen fibers

-Deficiency leads to less cross-linked collagen

30

What is mutated in Marfan's Syndrome?

Which organs are affected?

Autosomal disorder: Fibrilin-1 is mutated (weak elastin)

-affects ocular, skeletal, and cardiovascular systems