Flashcards in Exam 2 chapter 39 OA, RA, Gout Deck (33)
Inflammation of the joint
The symptom that most commonly causes a person to seek medical attention for rheumatic diseases
what are the most prevalent types of arthritis
disease that involves the joints, bones and muscles
which clinical manifestations are shared by rheumatoid arthritis (RA) and Osteoarthritis (OA)
which characteristic of rheumatoid arthritis (RA) differentiate it from other forms of inflammatory arthritis?
it has a destructive effect on the adjacent cartilage and bone
cold and stress induced vasospasm causing episodes of digital blanching or cyanosis
what are the classic symptoms of RA
lack of function
onset is usually acute
bilateral and symmetric
what is the cardinal sign of inflammatory arthritis that an appear even before pain?
lasting at least 30 to 45 minutes
name some extra-articular features of RA
lymph node enlargement
Raynaud's phenomenon (cold and stress induced vasospasm causing episodes of digital blanching or cyanosis)
Sjögren's syndrome (dry eyes and dry mucous membranes)
dry mucous membranes
Rheumatic disorders with diffuse inflammation and degeneration in connective tissues are referred to as
connective tissue diseases
what are some common connective tissue diseases
systemic lupus erythematosus (SLE)
The connective tissue disease that is a result of disturbed immune regulation that causes an exaggerated production of autoantibodies and antigens.
Systemic Lupus Erythematosus (SLE)
what is the first choice in the treatment of RA
The use of traditional NSAIDs
what are the primary goals in managing RA
maintain join function
prevent or correct join deformity
heat and cold therapy for RA
help relieve pain, stiffness, and muscle spasm
Ice is beneficial during periods of disease exacerbation
Ice application should not exceed 10 to 15 minutes at one time.
Tx options for RA
heat and cold application
patient and family teaching
Medical management of RA
NSAIDs and salicylates
inhibit the production of prostaglandins and provide anti-inflammatory effects and analgesia.
inhibit inflammatory processes
patient at risk for GI cimmpplications
Methotrexate (Rheumatrex, Trexall)
hydroxychloroquine (plaquenil) -antimalarial
biologic agents (immunomodulators)
The major end produce to purine catabolism?
primarily excreted by the kidneys
Increase cause GOUT
what is the most common initial problem of Gout?
inflammation of the great toe (podagra)
other affect joints are midtarsal area of the foot, ankle, knee and writs.
when does the onset of symptoms typically occurs in Gout?
at night with sudden swelling and excruciating pain peaking within several house.
what are some foods high in purine content which patient with Gout need to avoid?
red and organ meats
what will be prescribed for patient with acute Gout attack
antiinflammatory such as Colchincine
NSAID for pain management
Adrenocorticotropic hormone (ACTH)
future attacks of Gout are prevented by maintenance does of what?
Allopurinol (Zyloprim, Alloprim)
uricosuric such as probenecid (Benemid)
when may systemic corticosteroid be used for Gout?
only if routine therapies are contraindicated or ineffective.
Defect of purine metabolism will result in
hyperuricemia = GOUT
crystalline deposits accumulating in articular tissue, osseous tissue, soft tissue and cartilage.
Tophi seen in patient with chronic Gout
what will be the serum uric acid levels that will indicate gout?