Appendix C: Blood Brain Barrier Flashcards
How do nutrients get to the brain
Through the circulatory system
What are tight junctions
Gaps that prevents the free flow of substances into and out of the blood
How are the tight junctions different in the brain than elsewhere
The ednothelial cells are overlapping
What do the feet of the astrocytes do
Contribute to blood brain barrier which regulates what comes in and goes out
What are lipid soluble substances
Some gasses and steroids
What kind of gasses are lipid soluble
O2 and CO2
What steroids are lipid soluble
Sex hormones and cortisol
What is albumin
A protein carrier
What does albumin do
Steroids stick to these so it can travel through the cell membrane
What are the transport systems for amino acids
L-system and A-system
What are the transport systems of ions
Channels, sodium potassium pump
Where is there more K+ and more Na+
More K+ inside the cell and more Na+ outside the cell
Is there any blood brain barrier in the circumventricular organs
No
Why is there no blood brain barrier in the circumventricullar organs
Need to detect molecules in the blood and need to excrete into blood
What does the subfornical organ do
Circulating angiotensin II acts here to increase water intake
