C- Diuretics & RAAS Antagonists Flashcards
CO=
HR*SV
Increase Cardiac Output by increasing
Intropy
Heart Rate
Preload
Decrease CO by
Inc. Afterload
Specific Goals of Heart Failure Management with Pharmacotherapy
Reduction of congestion
Modulate neurohormonal activation
Improve flow
Used first as needed to reduce congestion
Reverse Na+ and fluid retention
Relieve volume overload: dyspnea peripheral edema
Lowers preload (LVEDP)
Diuretics
resulting in long-term stabilization, positive remodeling, and increased survival with RAAS antagonists and β-blockers
Modulate neurohormonal activation
Loop diuretics preferred because of ______- can augment with a thiazide diuretic
efficacy
may be difficult to accomplish pharmacotherapeutically with vasodilators and requires mechanical devices or transplantation
improve flow
ALDO–> Na+ sparing is the _______ but can cause K+ wasting
Major action
ALDO antagonists are ____ sparing
K+ sparing
fluid optimization with diuretics is a major part of heart failure therapy
Reduction of congestion
ALDO–> Na+ sparing is the major action but can cause ______
K+ wasting
ACE-ARB are ____ sparing
K+ sparing
Furosemide ______diructic
most common
Loop and thiazide are both ____ wasting
K+
