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Clinical Pathology > 17: Lymphoma 1 > Flashcards

17: Lymphoma 1 Flashcards

1
Q

What are four examples of lymphoproliferative diseases?

A

Lymphoma/lymphosarcoma, lymphoid leukaemia, plasma cell/mulitple myeloma, plasmacytoma (skin tumour)

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2
Q

What % of malignancies in cats are lymphomas?

A

30%

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3
Q

Which virus is lymphoma associated with in cats?

A

FeLV

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4
Q

What % of malignancies in dogs are lymphomas?

A

8-10%

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5
Q

Where in the genome is FeLV inserted?

A

Upstream of myc

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6
Q

What is the bovine version of FeLV?

A

Enzootic bovine leukaemia

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7
Q

What grade are lymphomas usually?

A

High

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8
Q

What % of lymphomas are B cell?

A

65-80%

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9
Q

What is the B cell marker?

A

CD79a

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10
Q

What is the T cell marker?

A

CD3

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11
Q

Is T cell or B cell a worse prognosis?

A

T cell

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12
Q

How many subtypes of malignant lymphoma are there?

A

More than 20

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13
Q

What is the best way to diagnose lymphoma?

A

Histopathology of a whole node following lymphadenectomy

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14
Q

What kind of lymphoma is the most common in the dog?

A

Multicentric

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15
Q

In what kind of dog is multicentric lymphoma most common?

A

Bull-type

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16
Q

What type of lymphoma is least common in the cat?

A

Multicentric

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17
Q

What is a complication of multicentric lymphoma?

A

Progresses to other organs

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18
Q

What stage are most lymphomas?

A

3 or 4

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19
Q

What is substage a?

A

Clinically well

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20
Q

What is substage b?

A

Clinical signs

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21
Q

What is stage 1 lymphoma?

A

Single node/organ

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22
Q

What is stage 2 lymphoma?

A

Single region +/- tonsil

23
Q

What is stage 3 lymphoma?

A

Generalised lymph node

24
Q

What is stage 4 lymphoma?

A

Hepatic and or splenic

25
Q

What is stage 5 lymphoma?

A

Blood or other organ

26
Q

What kind of lymphoma especially results in hyperCa?

A

T cell thymic

27
Q

What are 4 other common complications of lymphoma?

A

Anaemia, thrombocytopaenia, WBC abnormalities, hypergammaglobulinaemia

28
Q

What other organs can be affected by lymphoma in cattle?

A

Heart, abomasum, kidneys, ureters, epidural fat, intestine

29
Q

What are two clinical signs of thymic lymphomas?

A

Facial swelling and resp distress

30
Q

What age do thymic lymphomas present in dogs?

A

Variable

31
Q

What kind of lymphomas are thymic usually?

A

T cell

32
Q

What % of thymic lymphomas are FeLV positive?

A

90%

33
Q

What is the most common lymphoma in adolescent cattle?

A

Thymic

34
Q

Why won’t endoscopic grab biopsy not work for alimentary lymphoma?

A

Need deeper as can be diffuse or focal

35
Q

What are clinical signs of alimentary lymphoma?

A

Weight loss and diarrhoea

36
Q

What condition can resemble alimentary lymphoma?

A

IBD

37
Q

What can be a complication of alimentary lymphoma if it is upper SI?

A

Obstruction

38
Q

What can be a sign of alimentary lymphoma if it is lower LI?

A

Tenesmus/dyschezia

39
Q

Which species/age most commonly get alimentary lymphoma?

A

Elderly cats

40
Q

In which species is alimentary lymphoma less common?

A

Cattle

41
Q

What is the second most common lymphoma in the horse?

A

Alimentary

42
Q

Which breeds most commonly get T cell?

A

Boxer, bullmastiff etc

43
Q

Which breeds most commonly get B cell?

A

Golden retriever

44
Q

What’s an example of a low grade cutaneous lymphoma?

A

Epitheliotropic (round cells up to epithelium causing sloughing)

45
Q

What’s an example of a high grade cutaneous lymphoma?

A

Primary cutaneous (more nodular and deep)

46
Q

Which species gets extra-nodal lymphoma?

A

Cats

47
Q

What are some extra-nodal sites?

A

Renal, spinal, ocular etc

48
Q

Are extra nodal lymphomas bilateral or symmetrical?

A

Bilateral but not symmetrical

49
Q

What are the symptoms of a spinal lymphoma?

A

Acute-onset paresis

50
Q

How many lymph nodes should you FNA?

A

Several

51
Q

Why should you not FNA submandibular lymph nodes?

A

Often reactive to dental disease

52
Q

Which species is hard to diagnose lymphoma using FNA?

A

Cat

53
Q

What four parameters do you need for staging?

A

Physical exam esp palpation, urinalysis, biochem (Ca, urea, liver), CBC (RBC, WBC, platelets)

Clinical Pathology (30 decks)

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