Psychopharmacology: Treatment of Affective Disorders Flashcards Preview

Pharmacology - Exam 2 > Psychopharmacology: Treatment of Affective Disorders > Flashcards

Flashcards in Psychopharmacology: Treatment of Affective Disorders Deck (97)
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1

What are the barbiturates we need to know?

Phenobarbital

2

What are the benzodiazapenes we need to know?

  • diazepam
  • triazolam
  • alprazolam
  • clonazepam
  • midazolam

3

What are the benzodiazipine Receptor Agonists that We Need to Know?

  • zolpidem
  • eszopiclone

4

What benzodiazipine receptor antagonist do we need to know?

flumazenil

5

What is a melatonin congener?

ramelton

6

What is a 5-HT1a (minor) receptor agonist?

Non-sedative anxiolytic - buspirone

7

What drug classes act at the GABA receptor?

Barbituates

Benzodiazepenes

Benzodiazipine receptor agonists

Benzodiazipine receptor antagonist

8

Define sedative

drug causing a calming effect; tranquilizer

 

(Ideally, minimal effect on motor fxn or mental status)

9

Define hypnotic

sleep-inducing or promoting drug

10

What are the anxiolytics?

For reduction of anxiety

 

Note:  not all are sedatives

11

What does the dose-responsive curve for older sedatives (e.g., barbiturates) look like?

Linear - anxiolytic and sedative at low doses, at high doses coma and death

12

What does the dose-response curve for benzodiazepines look like?

Linear, but levels off at high doses

 

anti-anxiety and sedation at low doses

at high doses, harder to cause coma and death (SAFER than older sedatives)

13

What is the drug of choice for panic disorders?

1st line - antidepressants (SSRIs)

2nd line - alprazolam (benzo) 

14

What are the side effects of alprazolam in treatment of  anxiety?

rebound anxiety when discontinued

risk of dependence

15

What are the SSRIs?

fluoxetine

escitalopram

sertraline

16

What is an SNRI?

duloxetine

17

What are two TCAs?

amitriptyline

desipramine

 

18

What is an MAOI anti-depressant?

tranylcypromine

19

What are two "other" antidepressants?

bupropion

mirtazapine

20

What is true about the onset of therapeutic effects for all antidepressants?

therapeutic effects are delayed onset - about 2-6 weeks

21

Serotonin is converted from what and to what?

from L-tryptophan 

 

to melatonin (in the pineal gland)

22

serotonin interferes with the signaling of what other biomolecules?

platelets

23

fluoxetine

SSRI

24

sertraline

SSRI

25

escitalopram

SSRI

26

What is the mechism of action of SSRIs?

selectively block the serotonin uptake transporter (SERT), inhibiting the reuptake of 5-HT

27

what drugs are generally first line for treatment of depression?

SSRIs - better tolerated than older drugs

28

What drug-drug interactions do SSRI's mainly have?

CYP-2D6

(big ones -warfarin, tamoxifen is metabolite of CYP)

29

what are the t1/2 of most SSRIs?

long - about 24 hours

 

 

30

What are the common side effects of SSRIs?

  • CNS stimulation (insomnia, agitation)
  • GI problems (nausea, bleeding, diarrhea)
  • sexual dysfunction