What are the barbiturates we need to know?
What are the benzodiazapenes we need to know?
What are the benzodiazipine Receptor Agonists that We Need to Know?
What benzodiazipine receptor antagonist do we need to know?
What is a melatonin congener?
What is a 5-HT1a (minor) receptor agonist?
Non-sedative anxiolytic - buspirone
What drug classes act at the GABA receptor?
Benzodiazipine receptor agonists
Benzodiazipine receptor antagonist
drug causing a calming effect; tranquilizer
(Ideally, minimal effect on motor fxn or mental status)
sleep-inducing or promoting drug
What are the anxiolytics?
For reduction of anxiety
Note: not all are sedatives
What does the dose-responsive curve for older sedatives (e.g., barbiturates) look like?
Linear - anxiolytic and sedative at low doses, at high doses coma and death
What does the dose-response curve for benzodiazepines look like?
Linear, but levels off at high doses
anti-anxiety and sedation at low doses
at high doses, harder to cause coma and death (SAFER than older sedatives)
What is the drug of choice for panic disorders?
1st line - antidepressants (SSRIs)
2nd line - alprazolam (benzo)
What are the side effects of alprazolam in treatment of anxiety?
rebound anxiety when discontinued
risk of dependence
What are the SSRIs?
What is an SNRI?
What are two TCAs?
What is an MAOI anti-depressant?
What are two "other" antidepressants?
What is true about the onset of therapeutic effects for all antidepressants?
therapeutic effects are delayed onset - about 2-6 weeks
Serotonin is converted from what and to what?
to melatonin (in the pineal gland)
serotonin interferes with the signaling of what other biomolecules?
What is the mechism of action of SSRIs?
selectively block the serotonin uptake transporter (SERT), inhibiting the reuptake of 5-HT
what drugs are generally first line for treatment of depression?
SSRIs - better tolerated than older drugs
What drug-drug interactions do SSRI's mainly have?
(big ones -warfarin, tamoxifen is metabolite of CYP)
what are the t1/2 of most SSRIs?
long - about 24 hours
What are the common side effects of SSRIs?