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Flashcards in Principles of Blood Flow Deck (66)
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1

Stages 1-4 of blood flow and types of pressure

1: steady laminar flow in rigid vessels with static driving pressure
2. high Reynold's number flow (turbulence) with dynamic pressure
3. elastic vessel walls with pulsatile pressure
4. microcirculation with diffusion pressure

2

flow in series VS in parallel and where such things are the case

series: Q1=Q2=Q3... - in organ systems
parallel: Q=Q1+Q2 (if Q1 and Q2 are in parallel) - in general circulation

3

why the parallel architecture of circulatory system permits redistribution of blood flow

1. rate of blood flow to each tissue is almost always recisely controlled by tissue need
2. cardiac output is controlled mainly by sum of all local tissue flows
3. arterial pressure regulation is generally independent of either local blood flow or cardiac output control
4. blood is redistributed by adjustment of resistances (precapillary sphincters and arterioles) prior to capillary beds

4

blood to which organs increase/decrease during exercise?

increase: lungs, heart, brain, bone, muscle
decrease: digestive organs, kidneys

5

how does linear velocity vary with X-sectional area change?

linear velocity varies inversely as X-sectional area increases
v = Q/A

6

what is the general cardiac output?

5 L/minute

7

transit time

time required for a blood cell to travel between 2 points in the system
-t = length/velocity = volume/flow

8

blood as a fluid (approximations)

steady flow of incompressible fluids in rigid, straight, cylindrical tubes (good except for smaller vessels)
-not always true: flow is laminar with no slippage at wall, and viscosity is constant across diameter of vessel
--in reality, they don't slide past each other (stay in adjascent paths) but NOT so at boundary of vessel
--also, viscosity is highest at the borders

9

is blood compressible or incompressible?

incompressible

10

where does resistance to blood flow come from?

1. walls of the vessel (drag)
2. viscosity of the blood

both are frictional forces

11

what does mean linear velocity equal in regards to peak velocity?

MLV = 1/2 peak velocity

12

what is the major physiological variable that determines resistance to blood flow?

radius of blood vessels (mostly arterioles), then viscosity

13

relationship between temperature and viscosity

temperature is inversely related to viscosity (so colder = more viscous, less blood flow)
-vasoconstriction supplements temperature by reducing blood flow

14

relationship between pressure drop and radius, viscosity

the larger the radius, the smaller the pressure drop (inverse relationship)
the more viscous, the larger the pressure drop

15

turbulent flow

laminar flow that breaks down when velocity reaches critical point (for Re>3000; between 2000-3000 is transitional period)
-causes significant losses of kinetic energy

16

viscosity

measure of intermolecular attractions in liquid
-determines steepness of velocity gradient
-NOT density

17

Reynolds Number (Re)

Re = disruptive forces/cohesive forces

18

4 factors that generate pressure

1. gravity
2. compliance of vessels
3. viscous resistance
4. inertia

19

murmurs

audible sounds due to vibrations in heart or vessel walls (also called "bruit")
-don't occur under resting conditions

20

how does gravity affect blood pressure?

adds or subtracts from pressure generated by heart
-exists whether or not the heart is beating
-doesn't affect flow of blood in circuit of distensible vessels b/c gravitational pressure in arteries is exactly counter-balanced by same gravitational pressure at same level in corresponding veins
-does affect distribution of blood throughout system of distensible vessels

21

conclusions from Bernouli effect

1. as velocity decreases, dynamic pressure becomes smaller fraction of total pressure
2. as vessel radius narrows, dynamic component increases significantly

22

sheer stress

created by flowing blood on endothelial wall directed along long axis of vessel
-sheer stress on vessel wall is proportional to viscosity and shear rate (rate at which axial velocity changes from wall to lumen)

23

Poiseuille flow

sheer stress is directly proportional to viscosity and flow rate, and inversely proportional to cube of vessel radius
-measured in units of pressure

24

anomalous viscosity of blood

increase in viscosity at low flow rate (blood is non-newtonian, so viscosity changes)
-at low flow rates, rouleaux form, creating higher resistance

25

what does "to yield shear stress" mean?

blood behaves anomalously, meaning at low flow rates they need a threshold force to get moving

26

what does blood viscosity depend on?

1. fibrinogen (increased clots)
2. hematocrit
3. vessel radius (at diameters less than 0.3 mm, viscosity decreases)
4. velocity (higher flow = lower viscosity)
5. temperature (colder = higher viscosity)

27

Fahraeus-Lindqvist effect

at tube diameters less than 0.3 mm (arterioles, capillaries, venules) the apparent viscosity of blood decreases
-due to axial streaming (RBC accumulate in rapidly flowing axial lamina)

28

does plasma/saline viscosity depend on tube diameter?

no, they are independent

29

plasma skimming

tendency of cell-free plasma to be skimmed off at a branch point of microcirculation
-cause altered hematocrit in small vessels

30

how do the structure and function of microcirculation differ in different tissues?

1. nutritional source and waste removal in most vascular beds
2. filtration in renal glomeruli
3. thermoregulation in skin

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