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Flashcards in Hemepath Deck (63)
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1

Follicular lymphoma molecular

T(14;18) bcl2-IgH

2

Primary cutaneous follicle center lymphoma (PCFCL) vs nodal follicular lymphoma

Most cases PCFCL lack t(14;18) are Bcl6 pos, but Bcl2 and CD10 neg Vs in lymph node FL has t(14;18) and is pos for BCL6, BCL2 and CD10

3

APL flow

CD33+/CD177+/CD34-/HLA-DR-

4

immunophenotype CLL/SLL

B-cell markers: CD19, CD20 (*dim), CD22

CD5+ CD23+

Neg for CD10 Bcl6- FMC-7

*CD38 pos and ZAP-70+=bad prognosis

5

Immunophenotype mantle cell lymphoma

B-cell markers: CD19, CD20 (bright), CD22, FMC-7

CD5+ CD23- Cyclin D1+ CD43+

CD10/Bcl6- Bcl2+

6

Immunophenotype of follicular lymphoma

CD10+ Bcl6+ Bcl2+ (90%)

CD5- CD23-

t(14;18): IgH-Bcl2

7

Immunophenotype of marginal zone lymphoma

B-cell markers; nothing specific

8

Which two lymphomas express CD25

Hairy cell leukemia (also CD20, CD22, TRAP)

Adult T cell leukemia/lymphoma

9

What lymphoma shows T-cell rosettes?

NLP hodgkin lymphoma CD3+ CD57+ T cells surround LP cells forming rosettes

10

Burkitt lymphoma translocation

t(8;14) MYC-IGH

11

Which 3 lymphomas express CD30?

1. RS cells in HL

2. ALCL 

3. mediastinal B-cell lymphoma

12

What distinguishes plasmablastic lymphoma from other plasma cell neoplasms?

EBER+

13

Flow findings in PNH

-RBCs show loss of CD55 and CD59 

-Granulocytes show loss of CD16 and CD24

14

Which BCR-ABL isoform is associated with CML?

p210 isoform of t(9;22) BCR-ABL

15

Which BCR-ABL isoform is associated with B-ALL?

p190 isofrom of t(9;22) BCR-ABL

16

What subtype of AML is associated with thrombocytosis and giant agranular platelets?

AML with inv3

17

Translocation in acute monocytic leukemia

t(8;16) blasts with characteristic cytoplasmic vacuoles

18

Blasts w/ characteristic vacuoles

acute monocytic leukemia t(8;16)

19

Diagnosis?

toxoplasmosis

20

Favorable prognostic factors B-ALL

hyperdiploidy

t(12;21) TEL1-AML

21

Poor prognostic factors B-ALL

Hypodiploidy

t(9;22) BCR-ABL

del17p

t(11q23) MLL rearrangement

22

What B-cell neoplasm shows clumpy "soccer ball" chromatin on peripheral smear and cytology?

CLL/SLL

23

What translocation is found in mantle cell lymphoma

t(11;14) CCND1-IgH

results in cyclin D1 amplification

FISH is best assay

24

Diagnosis?

Marginal zone lymphoma

"monocytoid" lymps w/ abundant clear cytoplasm

25

Immunophenotype of hairy cell leukemia

B-cell markers: CD19, CD20, CD22

CD11c (bright) and CD25 (bright)

cyclin D1 (dim nuclear)

26

most common lymphomas in HIV infection

Burkitt

DLBCL (esp CNS)

Primary effusion lymphoma

, plasmablastic lymphoma

hodgkin lymphoma

 

27

Subtype of B-ALL/LBL with peripheral blood eosinophilia

t(5;14) IL3-IGH

28

What type of lymphoma typically presents as an anterior mediastinal mass often with hypercalcemia?

T-LBL

29

Good prognosis in CLL/SLL

normal karyotype or del13q only

mutated status of Ig heavy chain

30

Bad prognosis in CLL/SLL

-del11q or 17p

ZAP70 and/or CD38 expression

trisomy 12

lack of somatic hypermutation