Misc CP Flashcards Preview

Residency Boards > Misc CP > Flashcards

Flashcards in Misc CP Deck (36)
Loading flashcards...
1

Westgard rules

1:3S-1 value 3SD from mean, detects imprecision

2:2S-2 consecutive values >2SD on same side of mean, detects imprecision and systematic bias

R:4S-2 values in same run are >4SD from each other, detects random error

4:1S-4 consecutive values >1SD on same side of mean, defects systematic bias

10:mean-10 consecutive values on same side of mean, defects systematic bias

2

Friedewald equation

LDL=TC-HDL-TG/5 *not valid if TG>400

3

Corrected platelet count increment (CCI)

CCI= (post platelet count-pre count)xBSA/number of platelets transfused

Greater than 10,000 considered adequate response

4

What vitamin deficiency can cause pseudotumor cerebri?

Vitamin A

5

What lab test is best to evaluate liver functional status?

PT

6

What percentage of plasma volume is water?

93%

7

Category A bioterrorism agents

Variola (smallpox)

Hemorrhagic fever viruses

Bacillus anthracis

Yersinia pestis

Francisella tularensis

8

HCV genotype in US

Most common is genotype 1 (70%) of patients

Subdivided into 1a (60%) and 1b (10%)

1a more likely to develop resistance to treatment

9

Viruses which cause hepatitis

Hepatitis viruses EBV CMV HSV VZV Yellow fever

10

gram negative bacteria with bipolar staining (safety pin). What bug and exposure?

Yersinia pestis prairie dogs

11

Causes of viral gastroenteritis

Rotavirus (most common) Calciviruses (Norwalk-like) Enteroviruses serotypes 40&41 Adenoviruses Astrovirus

12

Define positive HIV-1 western blot

2 or more of the following bands: p24, gp41, gp120/160 If one or more bands present but criteria not met, test is indeterminate. Repeat within 6 mos or do NAT

13

Causes of granulomatous amebic encephalitis

Acanthamoeba Balamuthia mandrillaris

14

DDX For intracellular organisms

1. Leishmania-histiocytes, GMS neg 2. Histoplasmosis capsulatum-histiocytes GMS pos 3. Toxoplasma gondii- multiple cell types, some in cysts, GMS neg 4. Trypanosoma cruzi- multiple cell types (classically heart muscle), GMS neg

15

Types of malaria with q48hr fever (tertian)

P ovale P vivax P falciparum

16

Type of malaria with q72hr fever (quadrant)

P malariae

17

HbS protective against which malaria spp

Plasmodium falciparum

18

Duffy neg blood protective against which malaria spp

Plasmodium vivax

19

What mold produces aflatoxin

Aspergillosis flavus Aflatoxin is carcinogen producing HCC

20

What species of aspergillosis is resistant to amphotericin B

A terreus

21

Gorlin syndrome

“Nevoid basal call carcinoma syndrome” AD, PTC gene in chr9q Body overgrowth, jaw keratocysts, skeletal abnormalities and predisposition to neoplasms

22

Gaucher cell

inherited deficiency of glucocerebrosidase

Child p/w hepatosplenomegaly and hepatic dysfunction

23

Niemann-pick disease

foam cell

autosomal recessive d/o of lipid metabolism

24

What color top tube for ESR?

Lavendar

 

25

McLeod phenotype

-X-linked recessive disorder, lacking part of X chromosome encoding for Kell antigen on RBC

-acanthocytes on peripheral smear

-often have co-existing chronic granulomatous disease (since CGD gene is adjacent on X chr.)

26

HHV8 associated diseases

1. primary effusion lymphoma

2. kaposi sarcoma

3. multicentric castleman disease

27

Hardy-Weinberg equation

p^2+2pq+q^2=1

28

Testing that CLIA does not apply to

-Forensic

–Research tests

–Noninvasive tests (e.g. breath tests)

–Collection kits

–Workplace drug testing

29

What are 2 labs that pathologist cannot direct?

•HLA/Immunogenetics

•Cytogenetics

30

Formula for PPV

PPV % = TP/(TP+FP)

*PPV depends on disease prevalence; PPV increases as prevalence increases