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Flashcards in Blood Deck (317)
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181

Give the enzymes contained in the Eosinophil granulocyte

  • Histaminase
  • Aril-sulphatase
  • Myeloperoxidase
  • Acidic and alcalic phosphatase
  • Nuclease

182

During Chemotaxis, WBCs migrate towards which specific signals?

  • Products of tissue breakdown
  • Histamine
  • Complement factors
  • Chemotaxines produced by WBCs

183

Describe the antiallergic effect of Eosinophil granulocytes

  1. Basophil/Mast cell releases histamine and SRS-A
  2. Histamine and SRS-A enter eosinophil via pinocytosis
  3. Histaminase breaks down histamine
  4. Aryl-sulphatase breaks down SRS-A

184

SRS-A

Slow reacting substance of anaphylaxis

185

Mononuclear phagocytes

  • Contain Azurophyl granules (lysosomes)
  • Produces intracellular and extracellular enzymes
  • MPS: Mononuclear phagocyte system
  • MS: Macrophage system - antigen presentation, secretion
    • RES: Reticulo endothelial system
    • RHS: Reticulo hisiocytic system
  • Lifetime: 2-3 months in tissue

186

Polynuclear giant cells

Polynuclear phagocytes with dividing capacity

Increased phagocytosis

187

Describe the migration and chemotaxis of mononuclear phagocytes

Similar to neutrophil granulocytes

Circulating fraction is really small

Extravasal supply: tissue macrophages

188

Give the intracellular enzymes of mononuclear phagocytes

  • Proteases
  • Myeloperoxidae
  • Superoxid dismustase
  • Acidic and alcalic phosphatase

189

Give the extracellular enzymes of mononuclear phagocytes

  • Collagenase
  • Elastase
  • Angiotensine convertase

190

Give the macrophage cell of connective tissue

Histiocyte

191

Give the macrophage cell of liver

Kuppfer cells

192

Give the macrophage cell of the lung

Alveolar macrophage

193

Give the macrophage cell of lymphnodes

Fix and migrating macrophage

194

Give the macrophage cell of the spleen

Fix and migrating macrophage

195

Give the macrophage cell of bone marrow

Fix macrophage

196

Give the macrophage cell of pleura

Pleural macrophages

197

Give the macrophage cell of the peritoneum

Peritoneal macrophages

198

Give the macrophage cell of bone tissue

Osteoclasts

199

Give the macrophage cell of the nervous system

Microglia

200

Phagocytes not only demolish foreign bodies but...

The organism's own perished and aged cells

201

Describe antigen presentation in a specialised APC (antigen presenting cell)

  1. Macrophage eliminates pathogen
  2. Digested pieces of antigen from the pathogen are kept
  3. Antigen expressed on macrophage surface protein
    1. MHC-complex II (Main histocompatibility complex)
  4. T-cell receptor recognises the antigen fragment
  5. Immune system initiated
  6. Antibody production

202

Describe antigen presentation in an infected somatic cell

  1. Foreign material presented on cell surface
  2. Antigen presented on the MHC-I protein
  3. Cytotoxic T-lymphocyte recognises the MHC-I complex
  4. The infected cell is destroyed

203

Secretion of MPS (mononuclear phagocyte system) cells

Tissues are loosened by:

  • Collagenase
  • Elastase
  • Angiotensine convertase

Immune response is stimulated by:

  • Interleukin-1
  • Interferon
  • Prostaglandins

204

What is the effect of interleukin-1 on B-lymphocytes

Antibody synthesis

205

What is the effect of interleukin-1 on T-lymphocytes

Interleukin-2 synthesis

206

What is the effect of interleukin-1 on the hypothalamus

Production of fever

207

What is the effect of interleukin-1 on bone marrow

Neutrophil granulocyte production

208

What is the effect of interleukin-1 on fibroblasts

Collagen synthesis

209

What is the effect of interleukin-1 on the liver

Synthesis of acute phase proteins

210

Lymphocytes

  • Agranulocyte
  • Small, medium and big
  • Small/middle sized: Found in circulating blood
  • Large sized: Antigen specific lymphocyte subpopulations
  • B-lymphocytes (small)
  • T-lymphocytes (medium)
  • Lifetime: Hour to years
  • Antibody production
  • No phagocytosis