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Flashcards in Blood Deck (317)
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301

Coagulation factor: I fibrinogen

Elementary substance of the stable fibrin net

302

Coagulation factor: II Prothrombin

Central enzyme: Clot forming and elimination

303

Coagulation factor: III Tissue factor

Initiator of the extrinsic way

304

Coagulation factor: IV calcium ion

Fixes and activates the members of the cascade

305

Coagulation factor: V proaccelerin

A member of the central activator complex

306

Coagulation factor: VI

Not in use anymore

307

Coagulation factor: VII proconvertin

Initiator of the extrinsic way

308

Coagulation factor: VIII Antihaemophilic factor A

Member of the intrinsic activator complex

309

Coagulation factor: IX Christmas factor

Member of the intrinsic way

310

Coagulation factor: X Stuart-prower factor

Integrator of the intrinsic and extrinsic ways

311

Coagulation factor: XI plasma thromboplastin antecedent

Secondary initiator of the intrinsic way

312

Coagulation factor: XII Hageman factor - contact factor

Primary activator of the intrinsic way

313

Coagulation factor: XIII Lóránd-Laki, Fibrin stabilising factor function

Forms a fibrin-polymer from monomers

314

Coagulation factor: Kininogen

Activates factor VII and kallikrein

315

Coagulation factor: Kallikrein

Activates factor XII

316

The role of vitamin K

  • Calcium-binding gama-carboxyl-glutamic acid on the end of factors II, VII, IX, X and tissue factor GIa-proteins
  • Coenzyme of the carboxylation of the glutamic acid in the liver is reduced vitamin K

317

Practical significance of vitamin K

  • Natural intoxications
    • Dicumarol
  • Antagonises warfarin
    • Inhibits coagulation
  • Prevents thrombus formation
    • During surgical interventions
      • Cardiac valve etc.