Pharmacology - Chapter 44 - Antiinflammatory & Antigout Drugs

Question 0

What pregnancy category do NSAIDs fall under?

Answer 0

C- for first 2 trimesters,

D-for last trimester

Question 1

What is the mechanism of action for NSAIDs?

Answer 1

NSAIDs relieve pain, headache, and inflammation by blocking the chemical activity of the enzyme called cyclooxygenase (COX)

Question 2

What category of NSAIDs are aspirin in?

Answer 2

Salicylates

Question 3

Which drugs fall in the acetic acid derivatives category of anti-inflammatories?

Answer 3

Indocin (indomethacin)-treats rheumatoid arthritis
Toradol (kotorolac)-analgesic 
Voltaren (diclofenac sodium),
Clinoril (sulindac),
Tolectin (tolmetin),
Lodine (etodolac)

Question 4

Which drugs fall in the propionic acid derivatives category of anti-inflammatories?

Answer 4

Motrin, Advil (Ibuprofen),
Nalfon (fenoprofen),
Ansaid (flurbinprofen),
Orudis KT (ketoprofen),
Naprosyn, Aleve (naproxen),
Daypro (oxaprozin)

-profen, -oxen, -ozin extension

Question 5

Which drugs fall under COX – 2 inhibitors?

Answer 5

Celebrex (celecoxib)

Question 6

Which drugs are in the Enolic Acid Derivatives category?

Answer 6

Feldene (Peroxicam),
Mobic (Meloxicam),
Relafen (namumetone)

Question 7

What are the antigout drugs?

Answer 7

• Zyloprim (Alipurinol)-reduces production of uric acid
• Colchicine-reduces inflammatory response to a deposit of urate crystals in joint tissue
• Benemid (probenecid), Anturane (sulfinpyrazone)-increases excretion of uric acid in urine

Question 8

Salicylates toxicity

Answer 8

Adults: tinnitus and hearing loss
Children: hyperventilation and CNS effects

Metabolic acidosis and respiratory alkalosis may be present

Question 9

NSAID interactions may occur with which drugs?

Answer 9

Anticoagulants, 
aspirin, 
corticosteroids, 
protein-bound drugs, 
diuretics and ACE inhibitors

Question 10

Which herbal products are used to treat the pain of osteoarthritis?

Answer 10

Glucosamine and chondroitin

Question 11

Adverse affects of glucosamine and chondroitin?

Answer 11

GI discomfort,

Drowsiness, headache, skin reactions,

Question 12

Drug interactions with glucosamine and chondroitin

Answer 12

Enhance the affects of warfarin,

May increase insulin resistance