CNS Viral (lec 15)

Question 1

Poliomyelitis etiology?

Answer 1

poliovirus (picorna virus)

Question 2

Polio action?

Answer 2

multiply in pharynx/small intest ->
lymph nodes ->
CNS ->
anterior horn of spinal cord/motor cortex of brain

Question 3

Clinical syndromes of Polio: Inapparent

Answer 3

Most common

Asymp to minor malaise

Question 4

Clinical syndromes of Polio: Abortive

Answer 4

viral sxs + N/V

Question 5

Clinical syndromes of Polio:

Nonparalytic Poliomyelitis

Answer 5

viral sxs + N/V + stiff neck/back

Question 6

Clinical syndromes of Polio:

Paralytic Poliomyelitis

Answer 6

destruction of spinal cord lower motor neurons ->

asymmetric flaccid paralysis of extremities

Question 7

Clinical syndromes of Polio:

Post Polio

Answer 7

30-40 yrs after acute paralytic polio:

mm weakness, pain, fatigue

remaining neurons fail w/ overuse

Question 8

Polio vaccine?

Answer 8

e-IPV

enhanced inactive polio vaccine

Question 9

Arboviruses are?

Answer 9

arthropod-borne
vectors: mosquitoes/ticks
reservoir: US birds, small mammals
humans (U) dead-end hosts

Question 10

Arbovirus Group: Togaviridae?

Answer 10

Alphavirus: equine encephalitis
Flavivirus: west nile, dengue

Question 11

Arbovirus Group: Bunyaviridae?

Answer 11

california enceph

Question 12

Arbovirus presentation?

Answer 12

(U) asympt
Abrupt fever, HA, vertigo, photophob, N/V
Confusion, seizures

Question 13

West Nile diagnostics?

Answer 13

Time of yr/location/pt age

IgM w/ CSF (can be + if other flavivirus)

Question 14

Rabies presentation?

Answer 14

Prodrome: low fever, pharyngitis, HA, ↑ sensory

Excitatory: anxiety, hydrophobia

Paralytic: coma, hypoTN, death

Question 15

Rabies diagnostics?

Answer 15

Hx of bite
Test animal
Microbe = ssRNA, enveloped, bullet-shaped

Question 16

Rabies tx?

Answer 16

post-exposure prophy vaccine (HDCV)