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Q3 Microbiology test 2 > Bact PNA (lec 12) > Flashcards

Bact PNA (lec 12) Flashcards

1
Q

Cause of PNA: Φ predisposing factors?

A

pneumoniae:
Mycoplasma (no wall)
Strep (+)
Chlamy (-)

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2
Q

Cause of PNA: alcoholics/homeless/DM?

A

pneumoniae:
Strep (+)
Kleb (-)

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3
Q

Cause of PNA: underlying dz?

A

Strep pneumo (+)
H. flu (-)
P. aerug (-)
Staph aureus (+)

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4
Q

Cause of PNA: vent pts?

A

K. pneumo (-)

P. aerug (-)

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5
Q

Cause of PNA: travel/occupational?

A

Legion pneumo (-)

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6
Q

Cause of PNA: Community Acquired?

A

S. pneumo (+)
K. pneumo (-)
H. flu (-)
S. aureus (+)

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7
Q

Atypical PNA: zoonotic pathogens?

A 
Chlam psittaci
Fran tularensis (-)
Cox burnetii (-)
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8
Q

Atypical PNA: non-zoo pathogens?

A

Chlam pneumo (-)
M. pneumo (no wall)
Leg. pneumo (-)

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9
Q

Atypical PNA presentation:

Onset/Appearance?

Temp?

Chills/Shakes?

Cough?

Pleurisy?

CXR?

Other sxs?

A

Onset: gradual, Appearance: well

Temp: < 103

Chills/Shakes: rare

Cough: dry

Pleurisy: rare

CXR: patchy, undefined infiltrate

Other sxs: GI, aches

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10
Q

Atypical PNA resistant to what drugs?

A

β-lactams

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11
Q

Typical PNA presentation:

Onset/Appearance?

Temp?

Chills/Shakes?

Cough?

Pleurisy?

CXR?

Other sxs?

A

Onset: sudden, Appearance: sick

Temp: >103

Chills/Shakes: common

Cough: productive

Pleurisy: frequent

CXR: consolidation

Other sxs: chest pain, SOB

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12
Q

Strep pneumo microbe characteristics?

A

G+ diplococcus lances
⍺-hemolytic (green colonies)
Optochin sensitive (clearance around op disk)
Bile will lyse

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13
Q

Strep pneumo epidemiology?

A

young/old
cold/wet months
reservoir: asympt carriers

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14
Q

Strep pneumo Virulence Factor result of?

A

CAPSULE:
Φ phagocytosis
Φ complement
Φ opsonization by C3b

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15
Q

S. pneumo protection factors?

A

IgA protease: Φ host IgA

H2O2 prodxn: lyse host, kill competition

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16
Q

S. pneumo binding factors?

A

Pili: activate TNF

Surface proteins: bind choline on epi cells

17
Q

S. pneumo Pneumolysin is?

A

cytotoxin that forms pores in host membrane ->
lyse host,
activate complement

18
Q

S. pneumo Autolysin is?

A

enzyme produced in response to abx:
lyses host and pneumococcus ->
release pneumolysin,
↓ host immune response

19
Q

S. pneumo action?

A

causes immune response, allows replication of micorbe

fluid fills alveoli -> RBC/WBC -> consolidation

20
Q

S. pneumo resolution?

A

fluid reab and phago of bacteria

21
Q

S. pneumo diagnostic tests?

A

Aggultination = capsular polysacc

Genetic Probe = s. pneumo rRNA

22
Q

S. pneumo tx?

A

PCN G

23
Q

Klebsiella pneumoniae microbe characteristics?

A

G- bacillus

Slime capsule

24
Q

K. pneumo epidemiology?

A

Normal intest flora, aspirated

Nosocomal

25
Q

K. pneumo Virulence Factors?

A

POLYSACC CAPSULE:
Φ phagocytosis
Φ MAC lysis
Adhesion

26
Q

K. pneumo action?

A

Causes typical CAP/Nosocom:
necrosis of alv spaces, up lobes ->
inflamm and hemorr
(C) fatal

27
Q

K. pneumo presentation?

A

acute onset high fever
hemoptysis (currant jelly sputum)
abscess, cavitation

28
Q

K. pneumo diagnostic tests?

A 
Cx = mucoid capsule
CXR = cavitation
29
Q

K. pneumo tx?

A

aminoglyco + 3rd gen cephalo + fluoro

30
Q

Mycoplasma pneumo microbe characteristics?

A

Φ cell wall
“Fried egg” in culture
Sterols in plasma memb

31
Q

M. pneumo action?

A

Adhesion to epith -> release H2O2,
Φ airway clearance,
hides w/i host memb

32
Q

M. pneumo causes what infections?

A

Atyp PNA

otitis
rhinitis
pharyngitis
tracheobronch

33
Q

M. pneumo epidemiology?

A

(U) 5-20yo

Reservoir: p-to-p resp droplets

34
Q

M. pneumo diagnostic tests?

A

CXR = patchy infilt
Cx = mulberry colonies
Cold Agg = IgM’s bind I antigen of RBC

35
Q

M. pneumo DOC?

A

Azith/TCN

36
Q

Chlamydophila pneumo microbe characteristics?

A

G- cocci
Obligate INTRACELLULAR parasite

2 Forms:
Elementary Bodies (infectious)
Retic Bodies (intracellular)
37
Q

C. pneumo action?

A

Inflamm response,

Tissue destruction by bact replication

38
Q

C. pneumo epidemiology?

A

> 60yo

Reservoir: p-to-p resp droplets

39
Q

C. pneumo DOC?

A

TCN/Erythro

Q3 Microbiology test 2 (9 decks)

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