Flashcards in Rheumatology: Autoimmunity/ Systemic Lupus Erythematosus Deck (16)
What are two examples of organ specific autoimmunity?
2. Myasthenia gravis
What is an example of systemic autoimmunity?
Systemic lupus erythmatosus
What type of immunopathology is characterized by systemic lupus erythmatosus?
Type II AND Type III
Name the criteria for the diagnosis of systemic lupus erythmatosus..
1. Malar rash
2. Discoid rash
4. Oral ulcers
7. Renal involvement
8. CNS involvement (seizures or psychosis)
9. Hematologic disorders
11. Antinuclear antibodies
How many of the diagnostic criteria does a patient need to meet in order to be diagnosed with SLE?
4 out of 11
Does SLE effect more men or women?
What ethnicity does SLE effect more often?
African Americans and Hispanics
What are the genetic predisposing factors associated with SLE?
HLA-DR3 and C4A null alleles
What is upregulated in SLE?
INF-alpha and INF-beta it is called "INF Signature"
When is the onset of women with SLE?
What are two environmental factors that affect SLE?
--Estrogen: accelerating disease
2. Sun Exposure
--UV light > Keratinocytes > Cytokines > Increased antibody release
What are three specific antibody-mediated manifestations in SLE?
1. Hemolytic anemia
2. Anti-Phospholipid Antibodies
3. CNS Manifestations
Describe the process of hemolytic anemia seen in patients with systemic lupus erythmatosus.
Autoantibodies to red blood > Recruitment of complement > Destruction in the reiculoendothelial system
What does anti-phospholipid antibodies cause increased or decreased clotting?
Kind of both.
-Block prothrombin activation (clotting) elevated PTT
-But then increased clotting leading to thrombosis
Name some of the CNS manifestations seen in type II SLE.
What percentage of patients with SLE have CNS manifestations?
Anti-neuronal antibodies- depression, cognitive dysfuction, psychosis, seizures
Stroke or chorea due to vascular ischemia from vasculitis and thrombosis
66% of patients with SLE