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Blood and Lymph Unit 3 > Immunomodulators > Flashcards

Flashcards in Immunomodulators Deck (17)
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1

What are monoclonal antibodies?

Antibodies made by one clone

2

What process is used to make monoclonal antibodies?

B cells that make the appropriate antibody are fused to multiple myeloma tumor cells

3

What are antibodies that are derived from immunized mice called?

Murine (omab). All mouse antibody

4

What do you call antibodies that have the mouse VL and VH domains, but human C domains?

Chimeric (ximab)

5

What do you call antibodies in which only the CDR's of the V domain are derived from the mouse and the rest is human?

Humanized (zumab) antibody

6

What do you call a human antibody?

Human (-umab)

7

What is HAMA?

Human antimouse antibodies. Made by humans who have had repeated exposure to mouse antibodies

8

What is HAHA?

Human antihumanized antibodies

9

What is HACA?

Human antichimeric antibody

10

Descibe Natural Killer cells.

They are large granular lymphocytes (LGL)

They do not have rearranged V(D)J genes and are not thymic-derived

11

What mechanism do NK cells used to kill their targets?

Antibody-dependent cell-mediated cytotoxicity, or ADCC

They have Fc receptors for the receptor of IgG and can deliver a kill signal

12

How can you use passive antibody therapy in cancer?

You can tag antibodies, that can bind to a specific antigen on tumor cells, with a poison or a radioisotope these antibodies are called...

Immunotoxins

13

Describe BiTE (Bispecific T-cell Engager)

It is a two singe-chain engineered antibody. One against CD19 and one against CD3.

Brings together a T cell (CD3) to a CD19+ B cell lymphoma cell.

14

Name a BiTE drug that is used to treat Phildelphia-chromosome negative acute lymphoblastic leukemia (ALL).

Blinatumomab

15

There are some major drugs used in organ transplants please give the roles of the following three:

-Azathioprine

-Mycophenolate mofetil

-Glucocorticoids

-Azathiprine: Decreases DNA synthesis and mRNA transcription

-Mycophenolate mofetil: less toxic but same mode of action as azathiprine

-Glucocorticoids: anti-inflammatories in transplatation

16

There are some major drugs used in organ transplants please give the roles of the following three:

-Cyclosporine-A

-Tacrolimus

-Sirolimus

-Cyclosporine-A: Decrease IL-2 production

-Tacrolimus: Synergize with cyclosporine-A decrease synthesis and response to IL-2

-Sirolimus: inhibits a kinase called Target of rapamycin mTOR which is needed for T cell activation

17

There are some major drugs used in organ transplants please give the roles of the following two:

-Anti-thymocyte globulin (ATGAM)

-mAbs

-Anti-thymocyte globulin (ATGAM): Part of the regimen to prepare recipients for bone marrow transplantation and in acute organ rejection

-mAbs: Monoclonal antibodies against CD3 and IL-2