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A - Pre Reg COPY > Chapter 4 BNF (Anxiety & Depression) > Flashcards

Chapter 4 BNF (Anxiety & Depression) Flashcards

1
Q

What are the advantages to Buspirone?

A

Low potential for abuse and dependence

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2
Q

How do benzodiazepines work?

A

Facilitate binding of GABA to GABA receptor

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3
Q

What are the paradoxical side effects of benzodiazepines?

A

Increase in hostility

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4
Q

What’s the main feature of benzodiazepines overdose ?

A

Respiratory depression

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5
Q

How long does dependence take in:
Short acting?
Long acting?

A

Short acting: one day

Long acting: 3 weeks

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6
Q

Name as many TCAs a possible?

A 
Amitriptyline 
Clomipramine 
Imipramine 
Dosulepin 
Nortriptyline 
Lofepramine 
Doxepin
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7
Q

Name as many SSRIs as possible?

A 
Citalopram 
Escitalopram 
Fluoxetine 
Paroxetine 
Setraline
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8
Q

Name some Irreversible MAOIs?

A

Phenelzine
Isocarboxazide
Trancypromine

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9
Q

Name some reversible MAOI?

A

Meclobemide

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10
Q

Which TCA is least sedative?

A

Lofepramine

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11
Q

Which TCAs are most dangerous in overdose?

A

Amitriptyline

Dosulepin

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12
Q

Which TCA is least dangerous in overdose?

A

Lofepramine

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13
Q

Which TCA has the most antimuscarinic side effects ?

A

Imipramine

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14
Q

How long should other antidepressants be separated with MAOIs?

A

2 weeks

3 weeks (imipramine, clomipramine)

5 weeks (MAOI starts 5 weeks after fluoxetine)

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15
Q

Name some SNRIs?

A

Duloixetine

Venlafaxine

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16
Q

How long do antidepressants take to work? When should they be deemed ineffective?

A

Can take 2 weeks to work

Only deem ineffective after 4 weeks (6 weeks in elderly)

17
Q

How long should SSRIs be continued after remission? In normal cases, in GAD, and in recurrent ?

A

Normal: 6 months
GAD: 12 months
Recurrent: 2 years

18
Q

How do antidepressants affect electrolytes?

A

Hyponatremia ( especially SSRIs )

19
Q

How long should you wait before switching From:

TCAs
SSRIS
MAOI

A

TCAs: 1-2 weeks (clomipramine 3 weeks

SSRIs : 1 week (setraline 2 weeks, fluoxetine 5 weeks)

MAOIs: 2 weeks (meclobemide not necessary)

20
Q

After how long is the risk of withdrawal increased with antidepressants?

A

8 weeks

21
Q

Which antidepressants have a higher risk of withdrawal?

A

Paroxetine

22
Q

Which SSRIs cause QT prolongation

A

Citalopram escitalopram

A - Pre Reg COPY (37 decks)

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