Leukotriene Receptor Antagonists

Question 1

Give examples of leukotriene receptor antagonists (LTRAs).

Answer 1

Montelukast, zafirlukast.

Question 2

How do leukotriene receptor antagonists work?

Answer 2

Block the effects of inflammatory mediators called leukotrienes, in the airways.

Question 3

There is a risk of hepatic disorders with the use of leukotriene receptor antagonists (LTRAs), especially with zafirlukast. What signs and symptoms may indicate this?

Answer 3

Persistent nausea, vomiting, malaise, jaundice, dark urine.

Question 4

Churg-Strauss syndrome is a rare complication seen with leukotriene receptor antagonist. What are the signs and symptoms of this?

Answer 4

Eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, peripheral neuropathy.