Nephro Misc Flashcards

1
Q

pulmonary fibrosis, a form of restrictive lung disease can cause what metabolic imbalance?

A

Chronic respiratory acidosis

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2
Q

Signs of HYPOcalcemia

A

Chvostek’s Sign (facial nerve spasm)

Trousseau’s sign (inflation of BP cuff = carpal spasms)

Prolonged QT interval

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3
Q

QT interval in HYPERcalcemia

A

Shortened QT interval

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4
Q

Initial Dx test ordered for Nephrolithiasis

A

Noncontrast CT abd/pelvis

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5
Q

which stones are radiopaque (visible on radiographs)

A

calcium & struvite

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6
Q

Kidney Stones < 5mm in diameter Tx

A

Spontaneous passage: IV fluids, analgesic, antiemetics

Tamsulosin

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7
Q

Kidney Stones >7mm in diameter Tx

A
  1. Extracorporeal shock wave lithotripsy (breaks large stones)
  2. Uretoscopy + Stent: immediate relief in obstruction or at risk kidney
  3. Percutaneous Nephrolithotomy= large stones > 10mm
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8
Q

HUS Triad

A
  1. Hemolytic Anemia
  2. Thrombocytopenia
  3. Renal Insufficiency
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9
Q

Tx for HUS

A

Supportive

FFP (Plasmapheresis)

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10
Q

Dx for HUS

A

Increased BUN/Creatinine

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11
Q

TTP Pentad

A
  1. Thrombocytopenia
  2. Anemia
  3. Kidney failure
  4. Neuro sxs
  5. Fever
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12
Q

Diff b/w TTP & HUS

A

HUS lacks fever & neuro sxs in TTP

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13
Q

Dx for TTP

A

thrombocytopenia w/ normal COAGs

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14
Q

Tx for TTP

A

FFP

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15
Q

Antibodies vs ADAMTS13

A

TTP

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16
Q

Hallmark findings of Nephrotic Syndrome

A
  • Proteinuria
  • Hypoalbuminemia
  • edema
  • hyperlipidemia
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17
Q

Hallmark Findings of Nephritic Syndrome

A
  • Proteinuria
  • HTN
  • azotemia
  • oliguria
  • hematuria
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18
Q

UA in Nephrotic Syndrome

A

Proteinuria > 3.5g/day

Fatty casts, oval fat bodies “maltese cross”

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19
Q

US Nephritic Syndrome

A

Hematuria, RBC Casts

20
Q

Nephrotic Syndrome Bx

A

Hypocellular

21
Q

Bx of Nephritic Syndrome

A

Hypercellular

Crescent shape

22
Q

Minimal Change Disease is part of Which kidney syndrome?

A

Nephrotic Syndrome

23
Q

nephrotic syndrome in children

A

Minimal Change Disease

24
Q

Dx for minimal change disease

A

podocyte damage on electron microscope

loss of negative charge

25
Q

Tx for minimal change disease

A

Prednisone

26
Q

thickened glomerular basement membrane

*Nephrotic Syndrome*

A

membranous nephropathy

27
Q

What is the Gold Standard Dx for Nephrotic Syndrome

A

24 hr urine protein collection

28
Q

What determines the prognosis in nephrotic syndrome?

A

steroid responsiveness in minimal change disease

29
Q

Tx for minimal change disease

A

steroids

ACE, ARB for proteinuria

Diuretics for edema

30
Q

5 Causes of acute glomerulonephritis

A
  1. IgA Nephropathy (Berger’s Disease)
  2. Post infectious (Post GABHS)
  3. Rapidly Progressive GN
  4. Goodpasture’s Disease
  5. Vasculitis
31
Q

MCC of glomerulonephritis in adults

A

IgA nephropathy

32
Q

young males develop glomerulonephritis within days after URI or GI infection

A

IgA nephropathy

33
Q

Dx for IgA Nephropathy

A

+IgA mesangial deposits on immunostaning

34
Q

Tx for IgA Nephropathy

A

ACE-I + Steroids

35
Q

Post Infectious Glomerulonephritis

A

MC after GABHS

skin (impetigo) or pharyngeal infection

2-14 y/o boy w/ facial edema w/ coca colored urine

36
Q

Post Infectious Glomerulonephritis Tx

A

Supportive

37
Q

Dx for Rapidly Progressive Glomerulonephritis

A

crescent formation on Bx

38
Q

Tx for RPGN

A

steroids + cyclophosphamide

39
Q

Dx for post infectious Glomerular Nephritis

A

Increased Antistreolysin Titers

40
Q

Anti-GBM antibodies

A

Goodpastures Dz

41
Q

Complication of Goodpasture’s Disease

A

Kidney Failure & Hemoptysis

42
Q

Dx for goodpastures Disease

A

Linear IgG deposits

43
Q

Tx for goodpastures disease

A

Steroids + Cyclophosphamide

44
Q

PKD Tx

A

ACE, ARBs

45
Q

muddy brown cellular casts

A

Acute Tubular Necrosis

46
Q
A