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LATG Practice Questions > Chapter 6 Health Surveillance and Quality Assurance > Flashcards

Chapter 6 Health Surveillance and Quality Assurance Flashcards

1
Q

An animal supplier’s health status report is an assurance that the animal received in the facility is healthy and free of pathogens

A

False

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2
Q

Sentinel animals should be at least what age?

A

8-12 weeks

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3
Q

Which test detects known DNA sequences characteristic for the pathogen?

A

Polymerase chain reaction

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4
Q

Who decides which specific pathogens will be surveyed for in the animal facility?

A

Veterinarian, with input from the research team

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5
Q

How soon after exposure should a sentinel animal be tested for a specific pathogen?

A

3 to 6 weeks after exposure

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6
Q

Which pinworm infection can be detected by a tape test?

A

Syphacia

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7
Q

The presence of most bacteria can be confirmed by culture on artificial media

A

True

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8
Q

The pinworm Aspiculuris tetraptera

can be detected in mice by the anal tape test

A

False

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9
Q

What does the acronym MFI stand for?

A

Multiplex fluorescent immunoassay

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10
Q

In animal rooms where microisolation cages are being used, the sentinels are housed in cages that contain what item from other cages in the room?

A

Mixed bedding

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11
Q

If an animal tests negative for a pathogen 3 weeks after arrival at the facility, which conclusion can be drawn?

A

The animal was free of the pathogen when shipped

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12
Q

Serology is the best method to detect pathogens in immunodeficient animals.

A

False

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13
Q

The sentinel program detects mostly pathogens spread by fecal-oral contamination

A

True

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14
Q

Sentinel animals are experimental animals subjected to extra testing during the course of the study.

A

False

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15
Q

The best time to monitory for microbial antibodies is when the animals are very young.

A

False

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16
Q

Which activity must be done regularly in order to maintain the water quality in automatic watering systems?

A
  • Flush cage rack water lines
  • change in-line water filters
  • Sanitize water lines and connectors
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17
Q

Which of the following can be consequence of the introduction of insects or rodents in the facility?

A
  • Damage to electrical cords
  • Compromised experimental data
  • Food contamination
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18
Q

Which type of feed is most likely to be used by a facility that must meet GLP standards?

A

Certified diets

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19
Q

Which of the following is a contaminant that can be found in automatic watering systems?

A
  • Hydrocarbons
  • Heavy metals
  • Coliform bacteria
20
Q

Any feed can be autoclaved without loss of nutrients.

A

False

21
Q

Technology using adenosine triphosphate (ATP) test swabs uses (BLANK) to measure organic residue.

A

light

22
Q

Which of the following is NOT provided by data obtained from microbial monitoring?

A

Confirmation of the validity of study results

23
Q

What does the acronym “CFUs” stand for?

A

Colony forming units

24
Q

What is contained in the paper strips used to test sanitation during autoclaving?

A

Bacterial spores

25
Q

In addition to using tapes that indicate if the proper temperature was reached, cage washer effectiveness should be tested periodically for the presence of pathogens.

A

True

26
Q

Which statement regarding testing water bottles for bacterial colonies is FALSE?

A

Enteric pathogens are unlikely to be found in used water bottles

27
Q

All of the following can be increase a rodent’s susceptibility to infectious, toxic, and other harmful agents, EXCEPT which of the following?

A

Extra environmental enrichment

28
Q

Noise level above 85 decibels may cause which of the following effects?

A
  • Auditory effects in rodents
  • A rise in blood pressure in nonhuman primates
  • Auditory effects in humans
29
Q

Radios should no be permitted in any room where animals are housed.

A

False

30
Q

Levels of light photo intensity above (BLANK) foot-candles can cause retinal damage in some albino animals.

A

75

31
Q

Which environmental parameter is reduced inside the cage with the fuse of filter-top caging?

A

Ventilation

32
Q

Regulations and standards for USDA-regulated species are specified in which of the following?

A

Animal Welfare Act

33
Q

Which animal would be best to use as a sentinel in a room housing a mouse colony?

A

4-month old mouse

34
Q

Which technique is most used to detect Helicobacter spp.?

A

Polymerase chain reaction

35
Q

Which test eliminates the need for the animal to have antibodies to the infectious agent?

A

PCR rodent infectious agent PRIA

36
Q

Which of the following is an advantage of the adhesive plastic tape used to test the effectiveness of cage washers?

A

can be kept as a permanent record

37
Q

Which type of bedding is required in GLP studies?

A

Certified

38
Q

Which type of sampling can be used in place of bedding sentinels?

A

Environmental dust

39
Q

Which of the following is a main factor that determines the number of sentinels used?

A

expected morbidity of the agents being monitored

40
Q

Which of the following applies to certified feed?

A

The concentration of contaminants is below maximum acceptable levels

41
Q

One way to monitor the effectiveness of the cage washing system is to use adhesive plastic tape that changes color when exposed to a temperature of:

A

82 plus/minus 1 degree Celsius

42
Q

What is a common method used to detect exposure to viral pathogens?

A

Enzyme-linked immunosorbant assay (ELISA)

43
Q

Which type of bedding is required in GLP studies?

A

Certified

44
Q

Regulations and standards for USDA- regulated species are specified in which of the following?

A

Animal Welfare Act

45
Q

Which of the following applies to certified feeds?

A

The concentration of contaminants is below maximum acceptable levels.

LATG Practice Questions (22 decks)

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