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Micro and Immuno - Exam 2 > Childhood Viral Diseases > Flashcards

Childhood Viral Diseases Flashcards

1
Q

Measles Genome

A

-ssRNA

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2
Q

Measles Virion

A

enveloped

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3
Q

Measles Replication

A

In the cytosplasm

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4
Q

Measles inhibit host immune response by…

A

Interfering with CD46 and signaling lymphocyte activation molecule (SLAM) receptors

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5
Q

Measles incubation period

A

10-14 days

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6
Q

Measles Symptoms

A 
Syncytia
Kopalik spots
Rash
2-3 days of fever and cough
Coryza
Conjunctivitis
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7
Q

Measles Transmission

A

Aerosol transmission

One of the most contagious diseases known

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8
Q

Measles Complication

A

Because there is a host response, there is a risk for opportunistic infections
Blindness in Vitamin A deficient children
Acyute disseminated encephalymyelitis
Subacture sclerosing pancephalitis (rare)

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9
Q

Measles Prevalence

A

Was declared eliminated in the US in 2000, but is continually introduced by international travel
222 cases in 2012

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10
Q

Measles Prevention

A

MMR vaccine (live attenuated; lifelong immunity)

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11
Q

Measles Treatment

A

Providing Vitamin A can reduce severity

No antivirals

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12
Q

Respiratory Syncytial Virus Genome

A

-ssRNA

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13
Q

Respiratory Syncytial Virus Virion

A

enveloped

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14
Q

Respiratory Syncytial Virus Incubation

A

4-5 days

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15
Q

Respiratory Syncytial Virus Replication

A

Cytoplasm

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16
Q

Respiratory Syncytial Virus Symptoms

A

Upper and Lower Respiratory Tract infections

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17
Q

Respiratory Syncytial Virus Transmition

A

Inhalation of aerosols

Fomites

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18
Q

Respiratory Syncytial Virus Prevention

A

No vaccine

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19
Q

Respiratory Syncytial Treatment

A

No antivirals

Can be treated by passive immunoprophylaxis

20
Q

Varicella genome

A

dsDNA

21
Q

Varicella virion

A

enveloped

22
Q

Varicella incubation

A

10-21 days

23
Q

Varicella replication

A

Occurs in the nucleus

24
Q

Varicella Symptoms

A

Rash 1-2 days after infection, and progresses 3-6 days
Rash is on scalp, face, and trunk
Fever, malaise, headache

25
Q

Varicella Transmision

A

Inhalation of aerosolized droplets

26
Q

Varicella Complications

A

Usually establishes latent infections that can be reactivated - Shingles

27
Q

Varicella Prevention

A

Live attenuated vaccine that gives lifelong immunity

28
Q

Varicella Treatment

A

Acyclovir - interferes with genome replication

29
Q

Poliovirus genome

A

(+)ssRNA

30
Q

Poliovirus Virion

A

Non-enveloped

31
Q

Poliovirus Repliation

A

Occurs in the cytoplasm

32
Q

Poliovirus Symptoms

A

Limp

Respiratory paralysis

33
Q

Poliovirus Transmission

A

Ingestion of material containing the virus

34
Q

Poliovirus Prevalence

A

In endemic areas such that infections are most common in naive children (Not the US)
Targeted for eradication

35
Q

Poliovirus Prevention

A

There are 2 vaccines:
Salk (killed)
Sabin (live attenuated)

36
Q

What’s the difference between the 2 poliovirus vaccines?

A

Salk - killed; only antibody response

Sabin - live attenuated; both antibody and cell-mediated immunity

37
Q

Poliovirus Treatment

A

No antivirals

38
Q

Rotavirus Genome

A

dsRNA

39
Q

Rotavirus Virion

A

nonenveloped

40
Q

Rotavirus Incubation

A

2 days

41
Q

Rotavirus Replication

A

In the cytoplasm - mRNA gets excreted to serve as the template

42
Q

Rotavirus Symptoms

A

Vomitting, fever, diarrhea

Most severe in babies 6-24 months

43
Q

Rotavirus Transmission

A

Ingesting material containing the virus (fecal-oral)

44
Q

Rotavirus Prevention

A

Vaccines - RotaTeq, or Rotarix

Hygeine - hand washing

45
Q

Rotavirus Treatment

A

Oral rehydration

Micro and Immuno - Exam 2 (11 decks)

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