2013 NC State Mock Exam Tangent Questions C Flashcards Preview

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1

109. Which of the following statements would apply to a research institution that is PHS-Assured and USDA-registered, but is not AAALAC, International accredited?

 

a. Institution has a “category 1” assurance status and is required to submit their most recent IACUC semi-annual report with their Assurance for review
b. Institution has a “category 2” assurance status and is required to submit their most recent IACUC semi-annual report with their Assurance for review
c. Institution has a “category 2” assurance status and is not required to submit their most recent IACUC semi-annual report with their Assurance for review
d. Assurance status is irrelevant since all PHS-Assurance renewals require submission of the institution’s most recent IACUC semi-annual with their Assurance for review.
 

b. Institution has a “category 2” assurance status and is required to submit their most recent IACUC semi-annual report with their Assurance for review

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA. Chapter 2 – Laws, Regulations, and Policies affecting the Use of Laboratory Animals, pp. 25-26.
2) Office of Laboratory Animal Welfare.  2002.  Public Health Service Policy on Humane Care and Use of Laboratory Animals.  National Institutes of Health, Bethesda, MD, pp. 10-11. 
Domain 5

2

110.  Which of the following organisms is considered to be a normal inhabitant in the gastrointestinal tract of chinchillas?

 

a. Baylisascaris procyonis
b. Giardia spp.
c. Toxoplasma gondii
d. Yersenia spp.
 

b. Giardia spp.

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 7 – Biology and Diseases of Other Rodents, pp. 288-289.
2) Suckow MA, Stevens KA, Wilson RP, eds.  2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents.  Academic Press: San Diego, CA.  Chapter 42 – Chinchillas, Diseases and Veterinary Care, p. 998
Domain 1; Tertiary Species – Other Rodents

3

111.   How is the Goldblatt kidney model of renovascular hypertension created in rats?

Constricting one renal artery while leaving the other kidney intact

References: Suckow MA, Weisbroth SH, Franklin CL, eds.  2006.  The Laboratory Rat, 2nd edition.  Elsevier Academic Press: San Diego, CA.  Chapter 23 – Spontaneous, Surgically, and Chemically Induced Models of Disease, p. 719.
Domain 3; Primary Species – Rat (Rattus norvegicus)

4

112. All of the following describe the breeding cycle of guinea pigs EXCEPT?

 

a.  Induced ovulators
b.  Nonseasonal breeders
c.  Polyestrous
d. Spontaneous ovulators
 

a. Induced ovulators

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA.  Chapter 6 - Biology and Diseases of Guinea Pigs, p. 210.
2) Suckow MA, Stevens KA, Wilson RP, eds.  2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents.  Academic Press: San Diego, CA.  Chapter 21 – Management, Husbandry, and Colony Health, pp. 611-612
3) Percy DH and Barthold SW. 2007. Pathology of Laboratory Rodents and Rabbits, 3rd ed. Blackwell Publishing: Ames, Iowa. Chapter 5 – Guinea Pig, p. 217.
Domain 4; Secondary Species – Guinea pig (Cavia porcellus)

5

113.  The Public Health Service includes all of the following organizations EXCEPT?

 

a. Agency for Healthcare Research and Quality
b. Health Resources and Services Administration
c. Indian Health Service
d. National Science Foundation
e. Substance Abuse and Mental Health Services Administration
 

d. National Science Foundation

1) Office of Laboratory Animal Welfare.  2002.  Public Health Service Policy on Humane Care and Use of Laboratory Animals.  National Institutes of Health, Bethesda, MD. III. Definitions, p. 8 (http://grants.nih.gov/grants/olaw/references/PHSPolicyLabAnimals.pdf)
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA. Chapter 2 – Laws, Regulations, and Policies Affecting the Use of Laboratory Animals, p. 25
Domain 5

6

114. An assay was found to have the following sample results: 50 true positives, 1000 true negatives, 10 false negatives, and 5 false positives. What is the sensitivity of this assay?

 83.3%

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 10 – Microbiological Quality Control for Laboratory Rodents and Lagomorphs, pp. 385-386. 
Domain 1

7

115. What agent is an anti-epileptic drug that is has a non-opioid mechanism of action and has been used with other analgesics to provide chronic pain management in veterinary species?

Gabapentin

1) Committee on Recognition and Alleviation of Pain in Laboratory Animals, National Research Council. 2009. Recognition and Alleviation of Pain in Laboratory Animals. National Academies Press: Washington, DC. Chapter 4, p. 87.
2) McKeon et al. 2011. Analgesic effects of tramadol, tramadol-gabapentin, and buprenorphine in an incisional model of pain in rats (Rattus norvegicus). JAALAS 50(2):192-197
Domain 2

8

116. Which of the following is characteristic of the WHHL rabbit?

 

a.   Decreased plasma apolipoprotein E levels
b.   Deficiency of receptors for high-density lipoprotein in liver
c. Deficiency of receptors for low-density lipoprotein in liver
d. Increased plasma high-density lipoprotein levels
e. Reduced plasma low-density lipoprotein levels
 

c. Deficiency of receptors for low-density lipoprotein in liver

1) Kobayashi et al. 2012. Electrocardiograms corresponding to the development of myocardial infarction in anesthetized WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia. Comp Med 62(5):409-418.
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA.  Chapter 9 – Biology and Diseases of Rabbits, p. 331.
3) Suckow MA, Stevens KA, Wilson RP, eds.  2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents.  Academic Press: San Diego, CA.  Chapter 18 – The Rabbit as an Experimental Model, pp. 533-535
Domain 3; Primary Species – Rabbit (Oryctolagus cuniculus)

9

117.  Which of the following systems refers to the physical structure used to contain the water and aquatic animals as well as the ancillary equipment used to move and/or treat the water?

 

a. Aquarium
b. Aquatic support
c. Biofilter
d. Life support
e. Terrestrial support
 

d. Life support

1)  Institute for Laboratory Animal Resources. 2011. Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, D.C. Chapter 3 – Environment, Housing, and Management, p. 79.
2)  Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 19 – Biology and Management of the Zebrafish, pp. 871-873.
Domain 4

10

118. Which of the following agencies oversees regulations for the conduct of animal experiments relating to new or existing pharmaceutical medicinal substances, food additives or chemicals?

FDA

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA.  Chapter 1 – Laboratory Animal Medicine: Historical Perspectives, pp. 14-15; Chapter 2 – Laws, Regulations, and Policies Affecting the Use of Laboratory Animals, pp. 25-26, 29-30.
2) http://www.fda.gov/RegulatoryInformation/Legislation/default.htm  
Domain 5

11

119. Which organization advances the humane care and responsible use of laboratory animals through certification of veterinary specialists, professional development, education and research?

ACLAM

1) http://www.aclam.org/about-us
2) http://www.aalas.org/association/about.aspx
3) http://www.nabr.org/About_NABR/Mission_Statement.aspx
4) http://www.fbresearch.org/TwoColumnWireframe.aspx?pageid=102
2)  Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA.  Chapter 1 - Laboratory Animal Medicine, Historical Perspective, pp. 10-13.
Domain 6

12

120.  In which of the following species is the adult female larger than the male?

 

a. Mesocricetus auratus
b. Mus musculus
c. Mustela putorius furo
d. Oryctolagus cuniculus
 

a. Mesocricetus auratus

References: Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA.  Chapter 5 – Biology and Diseases of Hamsters, p. 169; Chapter 13 – Biology and Diseases of Ferrets, p. 486
Domain 1; Secondary Species – Syrian Hamster (Mesocricetus auratus)

13

121.  Which sheep breed is a model of congenital unconjugated hyperbilirubinemia? 

Southdown

1)  Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA.  Chapter 14 – Biology and Diseases of Ruminants: Sheep, Goats, and Cattle, p. 521.
2)   http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/22838.htm
3) http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/22839.htm
Domain 3; Secondary Species – Sheep (Ovis aries) 

14

122.  All of the following applies to HEPA filters EXCEPT?

a. Particles smaller than 0.3 um are removed with lesser efficiency
b. Bacteria, spores and viruses are removed from air by these filters
c. They remove particles of 0.3 um size with an efficiency of at least 99.97%
d. Particles larger than 0.3 um are removed with greater efficiency
e. HEPA stands for high efficiency particulate air
 

a. Particles smaller than 0.3 um are removed with lesser efficiency

1) U. S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, and National Institutes of Health.  2007.  Biosafety in Microbiological and Biomedical Laboratories.  5th ed.  U.S. Government Printing Office, Washington, D. C.   Appendix A – Primary Containment for Biohazards: Selection, Installation and Use of Biological Safety Cabinets, pp. 291-292
(http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5_appendixA.pdf).
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002.  Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 10 – Microbiological Quality Control For Laboratory Rodents and Lagomorphs, p. 369
Domain 4

15

123. According to the Public Health Service Policy on Human Care and Use of Laboratory Animals, what is a quorum and when is a quorum of the institutional use and care committee (IACUC) required?

 Majority of the total number of voting IACUC members; suspension of an activity

1) Frequently Asked Questions: Public Health Service Policy on Humane Care and Use of Laboratory Animals (http://grants.nih.gov/grants/olaw/faqs.htm)
2) Applied Research Ethics National Association (ARENA) and Office of Laboratory Animal Welfare (OLAW). 2002. Institutional Animal Care and Use Committee Guidebook.  2nd Edition.  OLAW, Bethesda, MD. A.2. Authority, Composition and Functions, pp. 15-16.
3) Office of Laboratory Animal Welfare.  2002.  Public Health Service Policy on Humane Care and Use of Laboratory Animals.  National Institutes of Health, Bethesda, MD. III. Definitions, p. 14
Domain 5

16

124. Which of the following is the most likely cause of reluctance to move, lameness, petechia, cranial enlargement, and joint pain in a young Saimiri spp.?

 

a. Excess vitamin A in the diet
b. Vitamin B12 deficiency
c. Vitamin C deficiency
d. Elevated levels of Vitamin D
e. Excess salt in the diet
 

c. Vitamin C deficiency

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 16 - Nonhuman Primates, pp. 757, -775.
Domain 1; Secondary Species - Squirrel Monkey (Saimiri sciureus) 

17

125.  According to the 2007 AVMA Guidelines on Euthanasia, which of the following animals can be euthanized by maceration?

 

a. 1 week old poults
b. Embryonic rodents
c. Day-old poultry
d. Tadpoles
e. Fish
 

c. Day-old poultry

Reference: American Veterinary Medical Association.  2007.  AVMA Guidelines on Euthanasia (Formerly Report of the AVMA Panel on Euthanasia), p. 17
(http://www.avma.org/issues/animal_welfare/euthanasia.pdf).
Domain 2; Tertiary Species – Chicken (Gallus domesticus) and Other Birds

18

126. Which of the following statements is TRUE regarding cryopreservation of rat sperm?

 

a. Freezing sperm in raffinose-modified Krebs-Ringer bicarbonate solution-egg yolk extender alone is the best preservation technique
b. Raffinose-modified Krebs-Ringer bicarbonate solution-egg yolk extender with ionomycin caused sperm lysis
c. Supplementation of the extender with lactate and ATP increases the number of motile sperm before freezing
d. Rat sperm has not been successfully cryopreserved
 

c. Supplementation of the extender with lactate and ATP increases the number of motile sperm before freezing

1) Yamashiro et al. 2010. Lactate and adenosine triphosphate in the extender enhance the cryosurvival of rat epididymalsperm. JAALAS 49(2):160-166.
2) Yamashiro et al. 2010. Extracellular ATP and dibutyryl cAMP enhance the freezability of rat epididymal sperm. JAALAS 49(2):167-172.
Domain 3; Primary Species – Rat (Rattus norvegicus)

19

127. Which of the following vitamins in laboratory rodent diets is most sensitive to autoclaving?

 

a. A
b. B1
c. B6
d. D3
e. Folate
 

b. B1

References:  Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds.  2007. The Mouse in Biomedical Research, 2nd edition, Volume 3 – Normative Biology, Husbandry, and Models.  Academic Press: San Diego, CA.  Chapter 10 – Nutrition, p. 362.
Domain 4

20

128. What act authorizes the Environmental Protection Agency to register and control the use of pesticides?

FIFRA (The Federal Insecticide, Fungicide, and Rodenticide Act)

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds.  2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA.  Chapter 2 – Laws, Regulations, and Policies Affecting the Use of Laboratory Animals, p. 27.
Domain 5

21

129.  All of the following mites are zoonotic EXCEPT?

 

a. Chirodiscoides caviae
b. Cheyletiella parasitavorax
c. Ornithonyssus bacoti
d. Trixacarus caviae
 

 a. Chirodiscoides caviae

1)  Percy DH and Barthold SW. 2007. Pathology of Laboratory Rodents and Rabbits, 3rd edition.  Blackwell Publishing: Ames, Iowa. Chapter 2 – Rat, p. 158; Chapter 5 – Guinea Pig, pp. 234-235
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002 Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 6 – Biology and Diseases of Guinea Pigs, pp. 225-228; Chapter 9 – Biology and Diseases of Rabbits, pp. 349-350; Chapter 25 – Selected Zoonoses, pp. 1096 (Table IV), 1098
3) Suckow MA, Stevens KA, Wilson RP, eds.  2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents.  Academic Press: San Diego, CA.  Chapter 15 – Parasitic Diseases, p. 431; Chapter 23 – Infectious Diseases, pp. 671-673; Chapter 32 – Parasitic Diseases, p. 862
Domain 1

22

130.  Corticosterone levels in rats can be used to evaluate which of the following?

 

a.  Decreases in corticosterone levels are a direct indicator of a stressful situation
b.  Decreases in corticosterone levels are an indirect indicator of a stressful situation
c.  Increases in corticosterone levels are a direct indicator of a stressful situation
d.  Increases in corticosterone levels are an indirect indicator of a stressful situation
 

d. Increases in corticosterone levels are an indirect indicator of a stressful situation

1) Costa et al. 2012. Handling of adolescent rats improves learning and memory and decreases anxiety. JAALAS 51(5):548-553
2) Turner et al. 2012. Oral gavage in rats: animal welfare evaluation. JAALS 51(1):25 -30
Domain 3; Primary Species – Rat (Rattus norvegicus)

23

131. What is the term for a group of genetically authentic mice of a particular stock or strain that is used to establish colonies by providing breeders?

Foundation colony

1) Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds.  2007. The Mouse in Biomedical Research, 2nd edition, Volume 3 – Normative Biology, Husbandry, and Models. Academic Press: San Diego, CA. Chapter 8 – Management and Design: Breeding Facilities, p. 236.
2) http://www.taconic.com/wmspage.cfm?parm1=367
Domain 4; Primary Species – Mouse (Mus musculus)

24

132.    The Occupational Safety and Health Administration limits employee exposure to noise to how many decibels measured on the A scale of a standard sound-level meter at slow response (dBA) averaged over an 8 hour work shift?

 90

Reference: Committee on Occupational Safety and Health in Research Animal Facilities, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council.  1997.  Occupational Health and Safety in the Care and Use of Research Animals.  National Academy Press, DC.  Chapter 3 – Physical, Chemical, and Protocol-Related Hazards, p. 41.
Domain 5 

25

133. Which of the following statements is TRUE regarding Aspiculuris tetraptera infection in mice?

 

a. Perianal tape test can commonly detect ova deposited by females while fecal float is unlikely to detect ova
b. A. tetraptera eggs are generally larger than those of S. obvelata, and are asymmetrically flattened on one side when seen microscopically
c. Examination of cecal and colonic contents is the best method for diagnosis
d. Adult female worms have smaller cervical alae than S. obvelata and a round esophageal bulb while males have prominent mamelons and a spicule
 

c. Examination of cecal and colonic contents is the best method for diagnosis

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002.  Laboratory Animal Medicine, 2nd edition.  Academic Press: San Diego, CA. Chapter 3 – Biology and Diseases of Mice, pp. 101-102
2) Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds.  2007.  The Mouse in Biomedical Research, 2nd edition, Volume 2 – Diseases.  Academic Press: San Diego, CA.  Chapter 22 – Helminth Parasites of Laboratory Mice, pp. 555-559.
3) Baker DG, ed. 2007. Flynn’s Parasites of Laboratory Animals, 2nd edition. Blackwell Publishing, Iowa, USA. Chapter 11 – Parasites of Rats and Mice, pp. 337-340
Domain 1; Primary Species – Mouse (Mus musculus)

26

134. Which of the following analgesia or anesthetic regimens is most effective and practical treatment to manage pain after tail biopsy in mice?

 

a. Buprenorphine
b. Ethyl chloride spray
c. Ice cold ethanol
d. Isoflurane
e. Lidocaine
 

a. Buprenorphine

1) Jones et al.  2012. Evaluation of common anesthetic and analgesic techniques for tail biopsy in mice.  JAALAS 51(6): 808-814. 
2) Hankenson et al. 2011. Behavioral and activity assessment of laboratory mice after tail biopsy under isoflurane anesthesia.  JAALAS 50 (5):686-694.  
Domain 2; Primary Species – Mice (Mus musculus)

27

135. Which of the following IS NOT a consideration when housing venomous species of reptiles in a research facility?

 

a. Avoidance of direct contact with caging
b. Security of animal housing
c. Appropriate training of personnel involved in care and use
d. A plan for immediate delivery of definitive medical care
 

a. Avoidance of direct contact with caging

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 18 - Biology and Diseases of Reptiles, pp. 836-837.
2) Committee on Occupational Safety and Health in Research Animal Facilities, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council. 1997. Occupational Health and Safety in the Care and Use of Research Animals.  National Academy Press, DC. Chapter 3 - Physical, Chemical, and Protocol-Related Hazards, pp. 33-34.
Domain 4; Tertiary Species - Reptiles

28

136. What is the recommended minimum space requirement per animal for 2 pigs housed together that are less than 25 kg each?

6 ft2

1) National Research Council.  2011.  Guide for the Care and Use of Laboratory Animals, 8th ed.  National Academies Press, Washington D.C.  Chapter 3 - Environment, Housing and Management, p. 62.
2) Committees to Revise the Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching. 2010.  GUIDE For the Care and Use of Agricultural Animals in Research and Teaching. 3rd Edition.  Federation of Animal Science Societies, Savoy, IL.  Chapter 11 – Swine, p. 148 (http://www.fass.org/docs/agguide3rd/Ag_Guide_3rd_ed.pdf)
Domain 4

29

137. According to the Animal Welfare Act and its regulations, which of the following individuals may request a full committee review by the Institutional Animal Care and Use Committee (IACUC) of a protocol describing proposed activities involving the care and use of animals?

 

a.   Any institutional employee
b.   Any member of the IACUC
c.   Institutional official
d.   Primary investigator
 

b. Any member of the IACUC

1) Animal Welfare Regulations, CFR Title 9, Chapter 1, Subchapter A – Animal Welfare, Part 2 – Regulations, Subpart C – Research Facilities §2.31 Institutional Animal Care and Use Committee (IACUC), (d)(xi)(2). (August 2002 Edition, p. 35)
2) Applied Research Ethics National Association (ARENA) and Office of Laboratory Animal Welfare (OLAW).  2002.  Institutional Animal Care and Use Committee Guidebook.  2nd Edition.  OLAW, Bethesda, MD.  Section C.1. Fundamental Issues, pp. 91-93.
Domain 5

30

138. All of the following applies to an NIH Research Project Grant Program (R01) EXCEPT?

 

a. Advance permission required for $500K or more (direct costs) in any year
b. Generally awarded for 3 -5 years
c. Maximum awarded amount of 1 million dollars
d. NIH's most commonly used grant program
e. Used to support a discrete, specified, circumscribed research project
 

 c. Maximum awarded amount of 1 million dollars

Reference: National Institute of Health. Office of Extramural Research.  (http://grants.nih.gov/grants/funding/funding_program.htm)
Domain 6