Spirochetes

Question 1

Spirochetes general facts-7

Answer 1

Coiled
CW
Motile
Endoflagella
Gm -
Stages of disease
Dark field microscopy or immunoflouresence

Question 2

Spirochetes types (4)

Answer 2

BBLT

• Borellia burgdorferi
• Borellia recurrent
• Leptospira interrogates
• Treponema pallidum

Question 3

Borellia burgdorferi

• virulence
• disease
• transmission
• Lab Dx
• Trx

Answer 3

The Bows and Arrows of Borrelia

• Surface exposed lipoprotein (OsPA-F) allow attachment to mammalian cell, OsPA vaccine prevented attachment to tick gut
• Lyme disease-1. days-Localized infection-slowly expanding erythema migrant that is hot to touch, burning 2. Disseminated infection-weeks/months-flu like sx, multiple lesions, pain in joints/msucles, bilateral bells palsy and Heart block 3. persistent infection-months to years-migratory polyarthritis in large joints, CNS issues (consuion/meningitis)
• Ixodes attachment of 24 hours-mouse is reservoir (of larvae), deer is obligatory host (of adult)-younger tick is more aggressive
• Elisa then W. blot, can’t culture-obligate intracellular organism
• Doxy prophylaxis or stage 1, ceftriaxone for later presentations

Question 4

Borelli recurrent

• virulence
• characterstics
• transmission
• special

Answer 4

• Surface exposed lipoprotein (OsPA-F) allow attachment to mammalian cell, OsPA vaccine prevented attachment to tick gut
• relapsing fever-edenic in tick bites, epidemic in louse/person to person–sudden onset of fever with chills, headache malaise-ending after 3-6 days, then relapse with decreased severity
• ticks/louse
• history
• relapse ability based to altering surface proteins

Question 5

Leptospira interrogans

• disease
• transmission
• trx

Answer 5

The Surfer’s Oasis

• Leptospirosis-enters body through mucosal membranes/ conjunctiva, asymptomatic or Weil’s disease-renal dysfunction and jaundice
• Swimming or ingestion of bacteria from contaminated water (urine of dogs/livestock/wild etc)
• prob doxy

Question 6

Treponema pallidum

• virulence
• disease
• transmission
• lab dx
• trx

Answer 6

• Penetrates intact mucous membrane-from 1/2 stage abscess
• syphillis-1 primary lesion with chancre at site-heals spontaneously (30%) 2. Disseminated-2ndary elsionsanywhere on body 3. Latent-serologically positive and blood is infectious 4. Aortic necrosis and meningitis/mental deterioration, inflammatory dmg, rarely skin/bone lesions (gummatous)–@ babies-rash, hepatosplenomegaly, bone infection ,saddle nose, saber shins
• any change of fluids-possibly even touching
• presence of reagin (VDRL test)-syphillis antibodies, flocculation test/completement fixation tests
• Penicillin-but when use-Jarisch Herxheimer rxn-dying bug has tons of LPS-cytokine storm