Clap and Mycoplasma

Question 1

Chlamydia Facts (6)

Answer 1

Obligate intracellular parasites with spore-like extracellular forms

Cant make ATP, has DNA and RAN

Human to human transmission

Multiply in inclusion bodies (in cytoplasms if host)

Target columnar epi

Non peptidoglycan layer

Question 2

3 types of clap

Answer 2

C. trachoma’s
C. pneumonia
C. psittaci

All pirates of Chlam island

Question 3

Clap into cells

Answer 3

elemental body (spore form), phagocytose, migrate to reticular body, multiply here making it in intermediate body, cell rupture and elemental body is release

Question 4

Chlamydia trachoma’s

• clinical characteristics
• transmission
• Dx
• trx

Answer 4

Pirates of Chlam Island

• oculular trachoma(conjunctivas-blindness from scaring+inclusion conjunctiva (acute, adult/perinatal), infant pneumonia (staccato cough) when mom has infection, GU tract infection-urethritis and PID, Reactive arthritis (Reiter’s syndrome), lymphogranuloma venerum (increase HIV risk)
• STI often travels with N. gonnoreha
• PCR based urine test (NAAT)
• Topical macrolide (newborns need ora), tetracyclines, (and ceftriaxone if have gonorrhea)

Question 5

Chlamdia pneumonia

• clinical characteristics
• transmission
• Dx
• trx

Answer 5

Pirates of Chlam Island

• Mild URI, atypical pneumonia
• ineffecient transfer by respiratory
• check for Ab
• doxycyline and if doesn’t work macrolide

Question 6

Chlamydia psittaci

• clinical characteristics
• transmission
• Dx
• trx

Answer 6

Pirates of Chlam Island

• psittacosis or ornithosis (from birds), fever headache sore throat, atypical pneumonia
• inhalation of bacteria on feathers or feces, or infected poultry
• history
• Probably macrolide and doxy

Question 7

Mycoplasma general facts-6

Answer 7

3 species-ureaplasma urealyticum, M. hominis, M. genitals (lock like fried egg)

• Men-urithritis, woman-bacterial vaginosis, cervicitis, PID
• Smallest free living orgs that can be cultured
• highly plieomorphic-no CW but 3 layers of PM (very resistant to Antibiotics)
• No gram stain
• fastidous-cholesterol in PM, need cholesterol to grow-grow slow

Question 8

Atypical pneumonia facts (3)

Answer 8

incubation of 2-3 weeks (viral is 1-3 days)

gradual onset of fever, headache, cough (sloughing of bacterium into lung lumen)

cold agglutinations of IgM (lyses RBC)
-problems for sickle cell or splenectomy-get disease worse-possible digital necrosis

Question 9

Mycoplasma pneumonia

• transmission
• virulence
• disease
• ID
• trx

Answer 9

Walking on Thin Ice

• repsitory droplets
• adhesion-high affinity for resp epi cell cola (CRITICAL FOR PATHOGENICITY), @ attachment lose cilia and cell sloughs into lumen=cough, H2O2 produced in other mech
• atylpical penuomina, URT