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2 Renal > Physiology 3 > Flashcards

Physiology 3 Flashcards

1
Q

the basal lamina is the same as the basement membrane of the capillary: T or F

A

T

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2
Q

gaps between podocytes are called…

A

filtration slits

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3
Q

the basement membrane is made up of what 2 structures?

A

collagen

glycoproteins

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4
Q

why does the basement membrane repel plasma proteins?

A

it is negatively charged and thus will repel negative plasma proteins

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5
Q

name the 3 filtration barriers of the glomerulus

A

glomerular capillary endothelium
basement membrane
filtration slits

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6
Q

name the 3 layers that make up the glomerular membrane (inner to outer)

A

endothelial cells in lumen
basement membrane
filtration slits

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7
Q

the pressure of blood in the capillary is known as?

A

glomerular capillary BP

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8
Q

biggest determinant of net filtration pressure?

A

glomerular capillary BP

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9
Q

blood pressure is constant in the glomerular capillary T or F

A

T

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10
Q

“oncotic” should make you think…

A

plasma proteins

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11
Q

name the 4 forces that determine the net filtration pressure

A

glomerular capillary BP
bowmans capsule hydrostatic pressure
bowman’s capsule oncotic pressure
capillary oncotic pressure

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12
Q

what does the capillary oncotic pressure do?

A

tries to attract fluid from bowman’s capsule into lumen of capillary

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13
Q

why is bowman’s capsule oncotic pressure negative?

A

no plasma proteins formed in tubular fluid of bowman’s capsule

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14
Q

how do you work out the net filtration pressure?

A

(GCBP + BCOP) - (COP + BCHP)

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15
Q

normal net filtration pressure?

A

10mmHg

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16
Q

main determinant of GFR?

A

GCBP

17
Q

normal GFR?

A

125ml/min

18
Q

what controls extrinsic regulation of GFR?

A

sympathetic control via baroreceptor reflex

19
Q

if blood pressure in the glomerulus is increased, what would happen to the GFR?

A

it would increase too

20
Q

how can the glomerulus control how much blood flows through it?

A

it can alter the diameter of the afferent arteriole

21
Q

how does sympathetic control reduce GFR?

A

causes vasoconstriction of blood vessels so will constrict the afferent arteriole

22
Q

MABP is?

A

93mmHg

23
Q

increased GFR will increase or decrease the amount of salt in the tubular fluid?

A

increase

24
Q

what do macula densa cells do when they sense salt in the tubular fluid?

A

release vasoconstrictive substances to bring GFR back to normal

25
Q

what effect would a kidney stone have on GFR and how?

A

would decrease it by increasing bowman’s capsule fluid pressure

26
Q

burns have what effect on GFR?

A

increase it

27
Q

what is plasma clearance?

A

the volume of plasma cleared of a particular substance per minute

28
Q

what kind of substance is inulin (NOT insulin)?

A

polysaccharide

29
Q

inulin clearance = GFR T or F

A

T

30
Q

how does inulin enter the urine?

A

filtration only (not by secretion or reabsorption)

31
Q

where is the main area of filtration in the kidney?

A

glomerulus

32
Q

clearance of urea is less than the GFR T or F

A

T

33
Q

a substance is said to be reabsorbed if clearance is more/less/equal to/than the GFR?

A

less

34
Q

a substance is said to be neither reabsorbed nor secreted if clearance is more/less/equal to/than the GFR?

A

equal to

35
Q

a substance is said to be secreted into the tubule if clearance is more/less/equal to/than the GFR

A

more

36
Q

best way to estimate GFR?

A

creatinine

2 Renal (34 decks)

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