Lymphoma Flashcards
How does Hodgkin’s lymphoma typically present?
painless cervical/supraclavicular lymphadenopathy in a young adult
Investigations for HL
ESR - elevated
CXR - mediastinal mass
Bone marrow biopsy - Hodgkins and Reed-Sternberg cells
risk factors for HL
EBV
immunosuppression
HIV
smoking
management HL
ABVD then escalated to BEACOPP
What is a risk of ABVD chemo?
pulmonary toxicity
What are the B symptoms associated with advanced HL?
recurrent fevers
drenching night sweats
weight loss
What are the different types of HL?
nodular sclerosis - younger people and women
mixed cellularity - older people
lymphocyte wish - better prognosis
lymphocyte-depleted - more RS cells, poor prognosis
which has more exranodal involvement, HL or NHL?
NHL
What is the common clinical picture of low grade NHL?
painless, slow growing lymphadenopathy spontaneous regression bone marrow involvement - cytopenia hepatomegaly and splenomegaly some extra nodal involvement and systemic symptoms
What is the common clinical picture of his grade NHL?
rapidly growing, buying lymphadenopathy
systemic symptoms and extra nodal involvement
large abode mass (burrkit’s)
hepatomegaly and splenomegaly
what are the types of low grade NHL?
follicular
MALT
woldenstroms macroglobulinaemia
What are the different types of hip grade NHL?
diffuse large B cell mantle cell burkitt's primary CNS primary effusion/body cavity
management of NHL
commonly R-CHOP chemo
burkitt’s CODOX and IVAC
