Evaluation of RBC Morphology Flashcards Preview

Veterinary Clinical Pathology > Evaluation of RBC Morphology > Flashcards

Flashcards in Evaluation of RBC Morphology Deck (37)
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1

Erythron

all RBC results, including analysis of regenerative response and morphologic features

2

Leukon

all WBC results, including total and differential leukocyte count, and assessment of WBC morphologic features

3

Thrombon

platelet number and size (check with slides)

4

Avian erythrocyte - normal shape is oval

5

What species' RBCs are these?

Normal canine erythrocyte - note central pallor, looks like donuts

6

Species?

normal canine erythrocytes - can tell by central pallor

7

Species?

normal equine erythrocytes

8

Species?

normal llama erythrocytes

9

Which species? 

normal feline erythrocytes

10

species?

bovine

11

This film demonstrates what type of RBC morphology disorder?

anisocytosis

12

This film demonstrates what type of RBC Morphology?

Hypochromasia

13

This film demonstrates what type of RBC Morphology?

Polychromasia

14

Are these "bullseye" RBCs an artifact or pathological?

Artifact - torocytes

15

This film demonstrates what type of RBC Morphology?

What species is this normal for?

Pokilocytosis - Normal in goats and young healthy cattle

16

Match RBC shape to species. ( may have to click photo to see all) 

Drepanocyte/sickle cell- deer

echinocyte- pig

dacrocyte - goat

ovalocyte - bird

elliptocyte - llama

17

These RBCs indicate what type of changes? 

These are echinocytes - indicate crenation, a reversible shape change.

Usually an artifact but can be due to snake bites, uremia, post transfusion PK deficiency, glomerulonephritis, neoplasia, doxorubicin, RBC dehydration, ATP depletion, increased pH, increased RBC calcium 

18

This RBC morphology change indicates what?

acanthocytes - liver disease, hemangiosarcoma, glomerulonephritis, DIC in dogs, normal in young goats/cattle, fragmentation when you have iron deficiency

19

This RBC morphology change indicates what?

keratocytes - iron deficiency anemia due to fragmentationliver disorders, various disorders associated with acanthocytosis such as DIC, doxorubicin toxicity in cats, formation potentiated by blood storage in cats

20

What are these and what do they indicate?

Schistocytes - fragmented cells usually due to DIC in dogs, severe iron deficiency, liver disease, hemangiosarcoma in dogs, myelofibrosis, glomerulonephritis, histiocytic disorders, PK deficiency post splenectomy 

21

Name the three categories of causes of RBC fragmentation.

Mechanical - ie. DIC, caval syndrome from heartworms, glomerulonephritis, cardiac valvular stenosis

Endothelial - hemangiosarcoma, vasculitis, splenic/hepatic disease

Thermal - heat stroke, severe burns

22

Characterize the anemia type and RBC morphologies seen with RBC fragmentation.

anemia is often mild/moderate and subclinical

morphologies - acanthocytes, keratocytes, schistocytes

23

How can you determine if a keratocyte was created by fragmentation or oxidative injury?

look at its company - if there are also heinz bodies assume oxidative, if also acanthocytes and schistocytes assume fragmentation

24

What bloodwork value often accompanies fragmentation and why?

thrombocytopenia, due to DIC

25

What are these and why do they exist?

stomatocytes - often artifact in thick blood films, hereditary (will see swollen RBCs with increased MCV and decreased MCHC), drugs that preferentially bind to inner half of lipid bilayer

26

What do spherocytes indicate?

IMHA (esp. in dogs)

snake bites, bee stings

zinc toxicity

hemoparasites

transfusion of stored blood

dyserythropoiesis in English springers, RBC band 3 deficiency in Japanese black cattle, partial spectrin disorder in golden retrivers

27

What is this and would you worry about it if you only saw 3 of them?

Leptocytes (ie. codocytes and knizocytes)

no - low numbers in normal dogs

increased in canine regenerative anemia, iron deficiency anemia, rarely liver disease, congenital dyserythropoiesis in English springers

28

If you saw these RBCs in a dog or cat blood smear would you be concerned?

Yes - they are elliptocytes, only normal for camelidae

in cats - marrow abnormalities, hepatic lipidosis, portosystemic shunts, doxorubicin toxicity

dogs - myelofibrosis, myelodysplastic syndrome, glomerulonephritis, hereditary RBC band deficiency

29

What conditions would cause RBCs to look like this?

being a deer or angora goat

hemoglobin polymerization when you have increased oxygen tension and pH

30

What is your plan if you see these in a dog blood smear?

Would that plan change if it was a ruminant blood smear?

Further diagnostics for dog - could be myelofibrosis, myeloproliferative disease, glomerulonephritis, or hypersplenism

For ruminant - usually indicates iron deficiency anemia so yes plan would change