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Pharm > corticosteroids > Flashcards

corticosteroids Flashcards

1
Q

short-medium acting glucocorticoids

A

Hydrocortisone (cortisol) (Cortaid®)
Prednisone Intensol
Methylprednisolone (Medrol)

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2
Q

intermediate-acting glucocorticoids
MORE anti-inflamm. potency
LESS mincort potency (vs short acting)

A

Triamcinolone(Nasacort)

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3
Q

long-acting glucocorticoids

A

Dexamethasone (Baycadron)

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4
Q

glucocorticoid synthesis inhibitor and antagonists

A

Metyrapone (Metopirone)

Ketoconazole (Nizoral) (*antifungal)

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5
Q

glucocorticoid and mineralocorticoid antagonists

A

Spironolactone (Aldactone)

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6
Q

glucocorticoid, mineralocorticoid, androgen, progesterone and estrogen agonist

A

Cosyntropin (Cortrosyn®)

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7
Q

mineralocorticoids agonists

A

Fludrocortisone

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8
Q

17-hydroxysteroids (17-OH)

A

steroid metabolite that can be measured in urine

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9
Q

if have mineral corticoid activity

A

promote Na reabsorption in renal distal tubules, inc. excretion potassium and hydrogen ions

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10
Q

allergy tx

A

prednisone
methylprednisolone
triamcinolone
dexamethasone

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11
Q

cerebral edema tx

A

prednisone

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12
Q

bacterial meningitis tx

A

dexamethasone

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13
Q

hematological disorders tx

A

prednisone, triamcinolone, dexamethasone

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14
Q

collagen disorders tx

A

prednisone, methylprednisolone, triamcinolone,

dexamethasone.

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15
Q

hepatic disease tx

A

prednisolone

+ azathioprine

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16
Q

renal disease tx

A

methylprednisolone

17
Q

respiratory tx

A

prednisone
betamethasone
dexamethasone

18
Q

learn adverse effects

A

!!

19
Q

GI SEs

A

decrease the mucus protection, inc. acid, ulcers

synergisim with NSAIDS–>inc. GI events

20
Q

edema SEs

A

fluid retention w/ heart/kidney disease, Na restriction

21
Q

carb/lipid metab SEs

A

hyperglycemia, aggravate DM

22
Q

hypokalemia SE

A

hypokalemia, met alkalosis, asthenia, paraylsis, arrythmias–>cardiac arrest

23
Q

hypophosphatemia SE

A

low levels blood phosphate

24
Q

osteonecrosis SE

A

femoral head, humeral head, femoral condyles, tibial plateau, talus, capitulum

  • fat embolism, hypercoag., inc. IOstP, fat swelling
  • joint pain 1st
25
Q

negative N balance

A

excessive breakdown, eat high protein diet to overcome

26
Q

CNS edema

A

behavior/personality changes

euphoria, insomnia, inc. appetite, nervousness, sleep diet, psychosis, paranoia

27
Q

growth suppression

A

children : should avoid using!!

28
Q

myopathy

A

loss of muscle mass, UE/LE
reversible
9a fluorinated steroids (i.e. triamcinolone)

29
Q

skin and soft tissue

A

purpura, skin thinning, SCC, BCC
acne, alopecia, hypertrichosis, striae
cushingoid features

30
Q

cushingoid features

A

truncal obesity, buffalo hump, moon face, weight gain

Pharm (45 decks)

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