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Pharm > T4: just drogas > Flashcards

T4: just drogas Flashcards

1
Q

hydrocortisone (cortisol) (cortaid)

A

short-to medium-acting glucocorticoid
anti-inflam: 1.0
mincort: 2+ (potent!)
initial tx of adrenalcortical insufficiency (also anti-inflam, UC)

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2
Q

prednisone (intensol)

A

short-to medium-acting glucocorticoid
anti-inflam: 4.0
mincort: 1+ (slight but signif)
anti-allergic, AIs, SLE, collagen, skin stuff, edema, endocrine, GI, blood, MS, Ca, eye, resp, rheum, tub. meningitis

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3
Q

methylprednisolone (medrol)

A

short-to medium-acting glucocorticoid

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4
Q

triamcinolone (nasocort)

A

Intermediate-acting glucocorticoid
anti-inflam: 5.0
mincort: 0 (none!)
intralesional, allergic rhinitis, eye, asthma, topical, adrcort insuff, endocrine, GI, blood, NS, kidney, rheum, allergic, SLE, resp

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5
Q

dexamethasone (baycadron)

A

long acting glucocorticoid
anti-inflam: 20-30!!
mincort: 0 (none!)
anti-inflamm., immunosuppr (lots) manage cerebral edema, sep. shock, swelling, dx agent (cushing’s), antiemetic, eye (conjunct), ear (OE)

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6
Q

metyrapone (metopirone)

A

Glucocorticoid synthesis inhibitor and antagonist

inhibits CYP11B1 (11 β-hydroxylase) which is the enzyme that converts 11-deoxycortisol to cortisol (both cortisol and ald. inhib)

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7
Q

ketoconazole (nizoral)

A

Glucocorticoid synthesis inhibitor and antagonist, antifungal
inhibits CYP17 (17 α-hydroxylase) and at higher concentrations CYP11A1 (cholesterol–>pregnenolone) effectively blocking all steroid biosynthesis
*most effective inhibitor for Cushing’s disease, acts quickly, can add metyrapone *synergism

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8
Q

fludrocortisone

A

synthetic mineralocorticoid agonist

both glucocorticoid and mineralocorticoid activity

  • added if using prendnisone/prednisolone or reduced dose hydrocortisone for 1/2 adrenocortical insufficiency (1: Addison’s) (need mineralcort. activity)
  • Na+ losing adrenogenital syndrome
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9
Q

spironolactone (aldactone)

A

glucocorticoid and mineralocorticoid antagonists
synthetic c 17- lactone- competes w. aldosterone (kidneys)
mineralcort. activitiy
edema, excessive aldosterone excretion? HTN, CHF etc. hypokalemia
normalize K+ before surgery (and low Na+ diet)

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10
Q

cosyntropin (cortrosyn)

A

glucocorticoid, mineralocorticoid, androgen, progesterone and estrogen agonist
synthetic derivative of ACTH
ddx prim. adrenal from secondary (pit) adrenocortical insuff.

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11
Q

aspirin

A

antiplatelet
irreversible*(for life of platelet) inactivation of COX 1 (endo. cells can resyn. enzyme)
suppr. syn of TXA2 (proaggr) and PGI2 (vadodil.)
(low dose sel. inhibs. TXA2 gen, preserves PGI2 prod.)
tx: prev. ME, ischemic attack, stroke, art. thrombi, vein graft occlusion (160-325 mg)
adverse: abd discomfers, epigastric pain, heartburn, nausea, GI bleeding, operative bleeding (w. warfarin), imp. hemostasis in mom/fetus

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12
Q

dipyridamole (persantine)

A

antiplatelet

blocks platelet adhesion to the vascular subendo. by inhibiting phosphodiesterase–>inc. cAMP (via inc. AC)

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13
Q

clopidogrel (plavix)

A

antiplatelet

inhibits ADP binding to receptor (P2Y12 component)–>prevents activation of GPIIb/IIIa, irreversible

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14
Q

tirofiban HCl (aggrastat)

A

antiplatelet

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15
Q

heparin (hep-lock)

A

anticoagulant
negatively charged, sulfated mucopolysacchs. (syn. in mast cells, abundant in lungs)
binds lys residues of protease inhib antithrombin III (neg moieties)
inactivates active factor Xa, thrombin (IIa), platelets
fast!
IV, subQ

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16
Q

enoxaparin sodium (lovenox)

A

anticoagulant (interfere w. fibrin formation, tx for venous thromboembolic disorders-stasis)

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17
Q

protamine sulfate

A 
heparin antagonist
used in OD-fast, last 2hrs (1: 100)
anticoag. effects of its own (CI?) 
-arginine, strongly basic, electropositive (hep is neg)
adverse: hypotension, anaphylaxis (fish)
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18
Q

warfarin sodium (coumadin)

A

anticoagulant
block vitamin K (epoxide reductase inhibition) (essential cofactor in the post-translational modification of clotting factors II, VII, IX and X and anticoag proteins C and S)–>unable to bind Ca2+, can’t form thrombin, can’t form clot
need to clear clotting factors for anticoag act. (typ. on heparin 1st), long-acting

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19
Q

lepirudin (refludan)

hirudins (leech)

A

anticoagulant
65 aa polypep, highly sp. inhib. of thrombin
used when heparin-induced thrombocytopenia
adverse: hypersn, bleeding, pregnancy, no antidote

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20
Q

alteplase (activase)

A

fibrinolytic
serine protease, sim. to tPA
infusion IV or into iccl. vessel
activates fibrin-bound plasminogen–>plasmin
reverse w/ aminocaproic acid/tranexamic acid

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21
Q

aminocaproic acid (amicar)

A

fibrinolytic

reverses fibrinolytics

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22
Q

factor VIII (hemofil M, koate)

A

hemostatics

for hemophilia A (factor VIII deficiency)

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23
Q

factor IX (bebuline)

A

hemostatic

for hemophilia B (factor IX deficiency)

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24
Q

phytonadione (mephyton)

A

synthetic vitamin K

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25
Q

tPA

A

fibrinolytic (from endothelial wall)

activates plasminogen–>plasmin (binds lysine res. of fibrin, which it cleaves and solubizes–>blood flow restored

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26
Q

protamine sulfate

A

antagonizes bleeding from heparin, positively charged (arginine), instantaneous
anticoag act of its own

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27
Q

vitamin K:

Phytonadione (MephytonR )

A

(cofactor) glutamic residues–>gamma-carboxyglutamic acid (2, 7, 9, 10)–>bind Ca2+ (PL surfaces) in clotting cascade
fat-soluble naphthoquinones

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28
Q

nutrient factors to tx anemia

A

Iron and combinations
Folic acid derivatives and combinations
Cyanocobalamin (Vitamin B12) and combinations

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29
Q

Calcium carbonate (Tums)

A

antacid
can cause “milk alkali”: renal damage
not for long term use
-drug interactions (dig. glyc, tetras, phentoin)-dec. bioavail.

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30
Q

Aluminum hydroxide and magnesium hydroxide (Maalox)

A

antacid
Al: constipation
MgCl: laxative
may accumulate in pts. with poor renal function
Al: hypophos., Alzheimer’s
-drug interactions (dig. glyc, tetras, phentoin)-dec. bioavail.

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31
Q

Cimetidine (Tagamet)

A

H2-Receptor Antagonist (parietal cells)
-in resp. to histamine, gastrin, and ACh (vagal stim)
-acute tx and ppc of PUD, also ZES and GERD
@night esp. effective
side effects: P450 (warf, theophy, pheynytoin) anti androgen effects, caution w. preggos

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32
Q

Ranitidine (Zantac)

A

H2-Receptor Antagonist

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33
Q

Omeprazole (Prilosec)

A

Proton Pump Inhibitor
irrev. inact. H+/K+ ATPase
GERD, PUD, ZES (suppr. basal and meal-stim gastric acid sec)
prodrug, absorb. in intestine
-reduces absorb. Ca, Mg, inc. inf., rebound acid hypersec., hyperplasia of ECL and parietal cells (lack of acid fdbk inhib of gastrin rel)
-alters bioavail., metab, interferes with clopidogrel

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34
Q

Pantoprazole (Protonix)

A

Proton Pump Inhibitor

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35
Q

Sucralfate (Carafate)

A

Mucosal Protective Agent
Al salt of sulf. sucrose
polymerizes–>sticky material that binds to exp. proteins in ulcer crater–>protective barrier
-SE: constip, drug interaxns, syst. effects w. imp. renal func

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36
Q

Misoprostal (Cytotec)

A 
Mucosal Protective Agent
analogue of PGE1
-inc. mucus prod, may reduce acid sec.
-prev. NSAID ind. ulcer
SE: not for preggos (ind. contractions) diarrhea, ha, aggrav. IBD
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37
Q

Bismuth subsalicylate (Pepto-Bismol)

A

Mucosal Protective Agent:
Colloidial bismuth compound, also for IBD
-coating action, antipepsin, *antibac activity (H. pylori)
Reye’s syndrome assoc. (avoid in kiddos)

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38
Q

Esomeprazole (Nexium)

A

Proton Pump Inhibitor

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39
Q

Lansoprazole (Prevacid)

A

Proton Pump Inhibitor

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40
Q

antimicrobials for PUD

A

no single drug v. effective, combo tx, incl. PPI/H2antag
raise pH–>inc. efficacy
“triple therapy”: metronidazole,colloidal bismuth (pepto), 1 of: amoxicillin, tetracycline, (not in kids: gray teeth), clarithromycin
probs: $, low pt compliance
Helidac therapy: dosage kit (bismuth subsalicylate, metronidazole, and tetracycline)
more combos

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41
Q

Dietary fiber [Bran, Psyllium (Metamucil)]
methylcellulose
polycarbophil

A

Bulk-Forming Laxative
take with simethicone: anti-flatulance/bloating
SE: fecal impaction/int. obstruct. (need to take w. water!)
-drug interaxns (cardiac glycosides)

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42
Q

Docusate sodium (Colace)

A

Stool Surfactant Agent (“fecal softener”)
detergent effect on stool, hospitalized pts
SE: affects solubility of drugs (more quickly)- space meds

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43
Q

Magnesium hydroxide (Milk of Magnesia)

A

Osmotic Laxative/Cathartic
can also neutralize stomach acid, acute use (1-6 hrs)
others: Mg sulfate, Mg citrate
risk: prol. usage in renal insuff. pt–>hypermag.

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44
Q

Polyethylene glycol

Miralax, Colyte, Go lytely

A

Osmotic Laxative/Cathartic
inert, nonabsorbable sugar, osmotic diuretic as well
(Na sulfate, NaCl, NaHCO3, KCl)
more long term use than Mg hydroxide, prep for dx/sx proc.
no bad SEs!

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45
Q

Bisacodyl (Dulcolax)

A

Stimulant Laxative/Cathartic
-inhibits abs. H2O, stim. peristaltic mvmnts
acute/some chronic constipation (2-8 hrs)
w/ polyeth. glycol for colon prep

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46
Q

Anthraquinone derivatives [Aloe, Senna (SennaKot)/sennosides, Cascara]

A

Stimulant Laxative/Cathartic

  • poor absorb., hydrolyzed in colon
    adverse: chronic use: melanosis coli (brown pig.), colorectal ca?
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47
Q

Metoclopramide (Reglan)

A

Prokinetic Agent
antiemetic, blocks dopamine receptors, 5HT
-also CRTZ
-gastroparesis, GERD, antiemetic

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48
Q

Erythromycin

A

Prokinetic Agent
stim. motilin, promotes gastric emptying
tx gastroparesis

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49
Q

Methylnaltrexone

A 
Prokinetic Agent
treat opioid-induced constipation in patients with advanced
illness (acts on intestinal u-opioid rec) 
given parenterally (subQ)
don't cross BBB, do not effect analgesic effects of opioids
50
Q

Alvimopan (Entereg)

A 
Prokinetic Agent (same as methylnaltrexone)
treat postoperative/paralytic ileum, short term (oral)
don't cross BBB, do not effect analgesic effects of opioids
51
Q

Methylcellulose

A

synthetic cellulose derivative

52
Q

Polycarbophil

A

acts like bulk forming agent

insoluble, hydrophilic, polyacrylic resin

53
Q

Lubiprostone (Amitiza)~

A

tx for chronic idiopathic constipation and IBS (females)
act. Cl channels, intest. BB–>inc. fluid sec (PG?)
not absorbed well from GI, few syst. effects
SE: nausea, diarrhea, flatulence, bloating, GI distress, ha
not safe during pregnancy?

54
Q

Linaclotide (Linzess)~

A

tx for chronic idiopathic constipation and IBS
activates guanyl cycles and inc. cGMP
not used in kiddos
SEs: diarrhea, cramp, dehyd. risk

55
Q

Dietary fiber [Bran, Psyllium (Metamucil), pectin, polycarbophil, cellulose]

A

Antidiarrheal Agent

bind excess water, bulk-forming

56
Q 
Bismuth subsalicylate (Pepto-Bismol) 
(colloidal bismuth compound)
A

antidiarrheal agent, acute, non-specific
absorb excess water, antimicrobial activity
slower acting than opioids, anti-inflamm.
“traveler’s diarrhea” (w. cipro)
*don’t use in kiddos (Reye’s)
adverse: syst. effects

57
Q

Loperamide (Imodium)

A

antidiarrheal agent, OTC, acute non-specific

dec. intestinal motility, constr. circular musc, relax long. musc, antimicrobial (unless in intestinal mucosa)
* opioid analog* (not into CNS, DOES cross BBB, pumped out)
* BUT drugs that inhibit P-gp (verapimil) then take loperamide can cause central opioid effects
- don’t use if infectious orgs.
adverse: toxic megacolon

58
Q

Dicyclomine (Bentyl)

A

Irritable Bowel Syndrome

antispasmodic, anticholinergic act.

59
Q

Hyoscyamine

A

Irritable Bowel Syndrome

antispasmodic, anticholinergic act.

60
Q

Lubiprostone (Amitiza)

A

Irritable Bowel Syndrome

61
Q

Sulfasalazine (Azulfidine)

A

Aminosalicylate (IBD)
salicylate-antiinflammatory (aspirin usually irritates upper GI), cleaved in bowel (sulfapyridine and amino salicylic acid)
antimicrobial
UC, Crohn’s
CI in sulfonamides, aspirin allergies (use *corticosteroids instead: short-term use)

62
Q

Mesalamine

A 
Aminosalicylate (IBD)
aminosalicylic acid(-5-ASA)
UC, antiinflammatory
irritating to upper GI, enema or oral
timed-rel, pH-sens
63
Q

Budesonide (Entocort)

A

Glucocorticoid (IBD)
enteric prep, acute attacks, mod-sec.
(also prednisone, etc, hydrocortisone enema)

64
Q

Azathioprine

A

Antimetabolite (IBD)
thiopurine
chronic sev. or steroid-resist. IBD

65
Q

Methotrexate

A

Antimetabolite (IBD)
dihydrofolate reductase inhibitor
chronic sev. or steroid-resist. IBD

66
Q

Inflixamib (Remicade)

A

Anti-Tumor Necrosis Factor Therapy (IBD)
MoAb, given IV
inactivates TNF-a, suppresses immune function
mod-sev Crohn’s
SE: hypersn, AI disorders, inf from IV, immsuppr

67
Q

Natalizumab (Tysabri)

A

Anti-Integrin Therapy (IBD)
mod-sev. Crohn’s (last resort)
give IV
adverse: dev. of multifocal leukoencephalopathy due to reactivation of hum. polyomavirus (JC virus)

68
Q

Simethicone (mylicon)

A

Anti-Flatulence Agent

69
Q

atropine

A

anticholinergic, anti-diarrheal, IBS

70
Q

propantheline

A

anticholinergic, anti-diarrheal, IBS

71
Q

dicyclomine

A

anticholinergic, anti-diarrheal, IBS

72
Q

Bethanechol (URECHOLINE, others)

A

Cholinergic agonist, inc. tone/motility GI

tx postop ileus, inc. lower esophageal sphincter tone

73
Q

Chenodiol (Chenix)
Ursodiol (Actigall)
Monooctanoin (Moctanin)

A

dissolution of gallstones

analogs of bile salts that alter cholesterol/bile sate metab. and help dissolve small gallstones

74
Q

lactase (Lact Aid)

alpha-D-galactosidase (Beano)

A

dig. enzymes, helps pts with enz. deficiencies, pancreatic disease

75
Q

morphine

A 
Strong Analgesic (μ agonist)
10mg subQ -good for sev. pain
IV doses lower
sedation/mental clouding (OD)
anxiety relief
euphoria
nausea (stim. CRTZ)
resp. depression *death* (can tx resp. distress in pulm. edema) 
pupil constriction
anti-cough
histamine rel. (use benadryl, naloxone)
lower seizure threshold
endocrine disturbs. 
sm. musc effects (constipa., reten, bronchoconstr., inc. biliary press.)
CV effects (hypotension, cut. vasodilation, inc. CSF press.)
skel musc. regidity
immunosuppression
76
Q

codeine

A 
Strong Analgesic (μ agonist)
weaker than morphine
antitussive (lower dose) *but can rel. histamine-->aggrav. asthma, etc.
77
Q

fentanyl

A 
Strong Analgesic (μ agonist)
patch or IV
short-term, fx
stronger than morphine-100 ug is typ. dose
78
Q

heroin

A 
Strong Analgesic (μ agonist)
acetylated morphine
79
Q

hydrocodone (Vicodin, Lortab, Norco, Zohydro ER, others)

A 
Strong Analgesic (μ agonist)
exs are hydrocodone + acetaminophen(inhib. PG prod)
problem: can OD, tox. doses of acetomin. 1st
-Zohydro ER: just hydrocodone, no acetomin. 
-antitussive (lower dose)
80
Q

hydromorphone (Dilaudid)

A

Strong Analgesic (μ agonist)
like morphine, more potent
IV, oral

81
Q

meperidine (demerol)

A 
Strong Analgesic (μ agonist)
-almost discarded, still around
82
Q

methadone (dolophine)

A 
Strong Analgesic (μ agonist)
-tx of heroin addxn
83
Q

oxycodone (Percodan, Percocet, OxyContin, Oxecta)

A

Strong Analgesic (μ agonist)
more powerful than hydrocodone
combo prod. w/ acetomin. (percocet)
Oxycontin: just opioid, used to get high “Billy heroin”: appalachia

84
Q

oxymorphone (opana)

A 
Strong Analgesic (μ agonist)
-pulled in 70s (drug users)
marked as having lower abuse potential-false
85
Q

pentazocine (talwin)

A

Partial Agonist and Mixed Agonist/Antagonist Analgesic

86
Q

buprenorphine (Buprenex, Sabutrex, Suboxone)

A

Partial Agonist and Mixed Agonist/Antagonist Analgesic

-replacement for methadone for opioid addxn, more readily available

87
Q

butorphanol (Stadol)

A

Partial Agonist and Mixed Agonist/Antagonist Analgesic

88
Q

tramadol (Ultram)

A

Partial Agonist and Mixed Agonist/Antagonist Analgesic

-weak u agonist, less intense “buzz”, dec. abuse pot.

89
Q

apentadol (Nucynta)

A

Partial Agonist and Mixed Agonist/Antagonist Analgesic

90
Q

naloxone (Narcan, Evzio)

A

opioid antagonist

-opioid OD, IV, inj.

91
Q

naltrexone (ReVia, Vivitrol)

A

opioid antagonist

-longer acting, oral: 12-24 hrs

92
Q

methylnaltrexone (Relistor)

A

opioid antagonist

93
Q

alvimopan (Entereg)

A

opioid antagonist

94
Q

naloxegol (Movantik)

A

opioid antagonist

-opioid-ind. constipation

95
Q 
warfarin sodium (coumadin) uses: ppx of thromboembolism: ???
adverse ???
A

nonvalvular a fib, valve HD, prosthetic heart valves, acute venous thrombosis, PE, MI, prevention of reocclusion of coronary artery bypass grafts, thrombosis prev. (CVCs), w/ chemo

hemorrhage, HTN (CVD), skin lesions (! switch to hep), GI, hypersn, alopecia, fever, leukopenia
pregnancy abnormalities (crosses placenta!)

96
Q

heparin uses ???
adverse ???
interactions ???

A

venous thromboemoblism, art. thromboembolism, extracorporeal circ., preggos (NOT coumadin), maintain patency fo indwelling catheters

adverse: thrombocytopenia, bleeding, hypersn, alopecia, burning in feet, local cap rupture
- suppr. aldosterone, interacts with insulin rec.

97
Q 
warfarin sodium (coumadin) interactions
and reversal w/ ??
A

may prolong oral anticoag respons: ASA, salicylates, etc
may diminish: corticosteroids, exc. vit K
-reversal w. vit K and FFP (2,7,9,10)

98
Q 
fibrinolytics (tPA, pro-urokinase)
uses?
3 things?
adverse?
reverse?
A

ven/art TE, shunts/catheters, occlusion of prost. heart valves

3: timing, lytic state, min. bleeding

sev. bleeding, IC hemorrhage, allergic rxs (strepto)
- rev. w/ fibrinolysis inhibs (aminocaproic acid)

99
Q

iron interactions ???
adverse ???
OD ???

A

absorption inhibited by: eggs, milk, coffee/tea, antacid, tetracyclines, FQs
enhanced by vit C

adverse: GI irritation, N/V, C/D, dark stools
lethal dose: 200-250 mg/kg (tox: 30-60)

tx w/ deferoxamine mesylate (desferal) when >300 -chelates iron, forms stable complex–>red urine

100
Q

deferoxamine mesylate (desferal)

A

iron OD when >300

chelates iron, forms stable complex–>red urine

101
Q

THF (metab. Folic acid) values

normal vs abnormal

A

Normal serum levels: 5-15 ng/ml;
normal CSF levels: 16- 21 ng/ml;
normal erythrocyte levels: 175-316 ng/ml.
megaloblastic anemia

102
Q

folic acid toxicity

A
  • giving to pts w/ undiagnosed anemia; may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress
  • prevented w/ vit B12
103
Q

folic acid adverse

A

rare hypersn, anorexia, naseau abdom. distension, etc, CNS effects (confusion, depression, alt. sleep, conc.)

104
Q

folic acid tx for

A 
megaloblastic anemia (may be tropical)
NOT for pernicious or other megaloblastic when vit B12 is deficient  (rule out before >0.1 mg dose FA)
-preggos: 0.4 mg/day
105
Q

hydroxocobalamin

cyanocobalamin

A

vit. B12, use for pernicious anemia

106
Q

erythropoietin (Epoetin Alfa, Epogen, Procrit)

A

natural: sec. by peritubular cells in kidney cortex in responses to hypoxia
stimulates prolif and maturation of committed erythroid progenitors to inc. red cell production
tx of anemia (chronic renal disease)
anemia of AIDS pts (zidovudine (AZT)
cancer chemo pts, autologous blood donation

107
Q

erythropoeitin adverse

A

flu-like, skin runs, arthralgia, (albumin), HTN in renal disease pts, clotting, seizures, hyperkalemia

108
Q

filgrastim (G-CSF) (Neupogen)

A

hum.granulo.-colony-stim factor
-regulates prod. of neutrophils in BM, enhances function of mature neutros, accel. recovery of neutro cell counts
BM transplant, chemo/HIV- neutropenia

109
Q

sargramostim (GM-CSF) (Leukine)

A

hum. granulocyte-macrophage colony-stim. factor
- supports growth and diff. of stem cells into granulos and macros, enhances chemotactic, anti fungal and anti parasitic act. of granulos and monos, accelerates myeloid recovery in lymphoma, leukemia, BM transplant pts., ca pts

110
Q

oprelvekin (IL-11) (Neumega)

A

IL-11: thrombopoietic CF, stim. prolif of megakaryocytic progenitor cells, maturation, and inc. platelet production
-prev. thrombocytopenia in ca. pts

111
Q

mineral oil

A

LC HCs from petroleum, poorly absorbed- stool softener

  • kids and debil. adults
    risks: pneumonitis (aspiration), dec. absorb. vit. ADEK, fat-sol. drugs, oil can leak!
112
Q

castor oil

A

hydrl. in sm. int–>ricinoleic acid–>inhib. fluid absorb, stim. peristalsis
v. intense!
bowel prep., but no longer recommended

113
Q

warfarin

A

-assoc. w/ valves, stenosis
long-term tx ops ischemic stroke-outweighs bleeding risk
maintain INR, inc. w. amiodarone(dec. dose!)
acetomin. may inc. INR

114
Q

newer anticoags for nonvalv. a fib, as good as warfarin in stroke prev.

A

dabigatran etexilate
rivaroxaban
apixaban
-less IC bleeding, no INR monitoring, fewer interaxns, no antidotes, not for ESRD

115
Q

dabigatran

A 
thrombin inhibitor
risk of GI bleeding
efflux transported of P-gp
dec. w/ rifampin
inc. w/ amiodarone (dec. dose)
116
Q

propranolol

A

heart block, hypotnsn, brady, bronchospasm, depression

117
Q

metoprolol

A

heart block, hypotnsn, brady, bronchospasm, depression

118
Q

diltiazem

A

heart block, hypotension, heart fail, brady, edema

  • amiodarone: both inc. (dec. dose)
  • pref. for asthma/COPD pts*
119
Q

verapamil

A

heart block, hypotnsn, heart fail, brady, dizzy, ha, fatigue, edema, nausea, constip.

  • inc. serum conc. with amiodarone-which inc. as well! (dec. dose)
  • pref. for asthma/COPD pts*
120
Q

digoxin

A

brady, Av block, arrhythmias, anorexia, N/V/D, abd pn, ha, confusion, abn vision
-pos. digoxin toxicity w/ amiodarone!

Pharm (45 decks)

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