Chemotherapy Agents Flashcards Preview

SB_Medication Side Effects (Pediatrics Royal College 2018) > Chemotherapy Agents > Flashcards

Flashcards in Chemotherapy Agents Deck (19)
Loading flashcards...
1

What are the SE for vincristine?

1. Constipation*
2. Peripheral neuropathy - foot drop and loss of DTR*
3. Jaw pain
4. Shin pain
5. Hepatotoxicity

2

What are the SE for vinblastine?

1. Mild neurotoxicity
2. Mucositis

3

What are the SE for doxorubicin?

1. Severe tissue damage with extravasation
2. Worsens the effects of XRT
3. Acute cardiac toxicity i.e. arrhythymias, acute drop in LV function, pericarditis
4. Chronic cardiomyopathy*

4

What are the SE for daunomycin?

1. Severe tissue damage with extravasation
2. Worsens the effects of XRT
3. Acute cardiac toxicity i.e. arrhythymias, acute drop in LV function, pericarditis
4. Chronic cardiomyopathy*

5

What are the SE for cisplatin?

1. Highly emetogenic
2. Renal toxicity - Mg wasting, azotemiaNeurot
3. Permanent hearing loss*
4. Sensory peripheral neuropathy

6

What are the SE for carboplatin?

1. Permanent hearing loss
2. Delayed myelosuppression
3. Hypersensitivity reactions

7

What are the SE for ifosfamide?

1. Hemorrhagic cystiits*
2. SIADH
3. Proximal tubular damage
4. Neurotoxicity - somnolence disorientation, lethargy

8

What are the SE for cyclophosphamide?

1. Hemorrhagic cystitis*
2. SIADH
3. Cardiac toxicity with high doses

9

What are the SE for etoposide?

1. Hepatotoxicity
2. Hypersensitivity reactions
3. Secondary acute leukemia*

10

What are the SE for cytarabine?

1. "Ara-C" Syndrome: high fever, malaise, rash, conjunctivitis, myalgias* - relieved by co-administration of corticosteroids
2. Mucositis
3. Neurotoxicity

11

What are the SE for mercaptopurine?

1. Hepatotoxicity
2. Mucositis

12

What are the SE for thioguanine?

1. Hepatotoxicity
2. Mucositis

13

What are the SE for methotrexate?

1. Mucositis
2. Rash
3. Hepatotoxicity
4. Nephrotoxicity - avoid by using hydration, alkalinization and leukovorin
5. Neurotoxicity - acute stroke-like encephalopathy and seizures

14

What are the SE for imatinib?

1. Nausea
2. Transient elevation of LFTs
3. Fatigue
4. Diarrhea

15

What are the SE for tretinoin (ATRA)?

1. Teratogenicity*
2. Pseudotumor cerebri*
3. Cheilitis
4. Conjunctivitis
5. Headache
6. Xerosis
7. ATRA syndrome:
a) Weight gain
b) Respiratory distress
c) Serous effusions
d) Cardiac and renal failure

16

What are the SE for dactinomycin?

1. Severe tissue damage with extravasation
2. Hepatic veno-occlusive disease
3. Mucositis
4. Can worsen effects of XRT

17

What are the SE for bleomycin?

1. Interstitial pneumonitis that can lead to pulmonary fibrosis*
2. Dermatologic toxicity
3. Mucositis
4. Fever
5. Hypersensitivity
6. Raynaud's phenomenon

18

What are the SE of asparaginase?

1. Allergic reactions
2. Coagulopathy*
3. Hepatotoxicity
4. Pancreatitis*

19

What are the SE of corticosteroids?

1. Weight changes
2. Mood changes
3. Hypertension
4. Myopathy
5. Avascular necrosis of hips*
6. Osteopenia
7. Hyperglycemia
8. Coagulopathy
9. Peptic ulcer