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1

Lymph

Fluid similar to plasma (without plasma proteins)

2

Lymphatic Vessels

a. lymphatic capillaries
b. lymphatic trunks
c. lymphatic ducts

3

Cells in the lymphatic system

lymphocytes, phagocytes, other cells

4

Lymphoid tissues

EX
a) tonsils
b) MALT (mucosa associated lymphatic tissue)

5

Lymphoid organs

spleen, thymus, lymph nodes

6

What does the lymphatic system do?

Protect us against disease

7

What do lymphatic system calls respond to?

Pathogens (viruses, bacteria, fungi, parasites)
Toxins
abnormal body cells such as cancers.

8

What is immunity, and what is involved in the immune system?

immunity is the ability to resist infection and disease

all cells and tissues are involved in production in immunity, NOT just lymphatic system

9

Which is greater, immune or lymphatic system?

IMMUNE SYSTEM

10

Specific defenses of lymphocytes

part of the immune response

identify, attack, and develop immunity to a specific pathogen

11

Non-specific defenses

block or attack any potential infectious organism. cannot distinguish one attack from another

12

Function of the lymphatic system

To produce, maintain, and distribute lymphocytes

13

Lymphocyte production

lymphocytes are produced in:

-lymphoid tissues (tonsils)
-lymphoid organs (spleen, thymus)
-red bone marrow

14

Lymphocyte circulation

from blood to interstitial fluid thru capillaries
-returns to venous blood thru lymphatic vessels

15

Fluid circulation

-from blood plasma to lymph and back to the venous system
-transports hormones, nutrients, and waste products

16

Difference between lymphatic and blood capillaries

lymphatic capillaries:
a. originate as pockets
b. large diameter
c. thinner wall
d. irregular shape in cross section
e. have lymphatic valves

17

Lymph flow

from lymphatic capillaries to larger lymphatic vessels containing one way valves

18

Lacteals

special lymphatic capillaries in small intestine, transport lipids from digestive tract

19

2 lymphatic ducts:

thoracic and right lymphatic duct

20

Thoracic duct

a. drainage areas including the left upper and whole lower body
b. entering venous system in the left subclavian vein, the superior vena cava and right atrium
c. enlarged site is called cisterns chyli

21

Right lymphatic duct

a. drainage areas including right upper of the body
b. entering right subclavian vein, then superior vena cava and right atrium

22

What percent of white blood cells are lymphocytes?

20-30% of WBC

23

T cellls

80% thymus dependent cells
a. cytotoxic t cells: cell mediated immunity
b. helper t cells: stimulate t and b cells
c. suppressor t cells: inhibit t and b cells

24

B cells

(10-15%) bone marrow derived cells
1. antibody (Ab) - mediated immunity (humoral immunity)
2. differentiate into plasma cells to produce Ab
3. ab also called immunoglobulins
4. life span of b lymphocytes4-20 years

25

NK cells

5-10% natural killer cells
a. also called: large granular lymphocytes
b. act as immunological surveillance

26

Cytotoxic T Cells

-attack cells infected by viruses
- produce cell mediated immunity

27

Memory T cells

formed in response to foreign substance
- remain in body to give immunity

28

Helper T cells

simulate function of t cells and b cells

29

Suppressor t cells

inhibit function of t cells and b cells

30

regulatory t cells

-are helper and suppressor t cells
- control sensitivity of immune response