What are different categories of drugs for alimentary disease?
Drugs affecting GI motility
Drugs for inflammatory bowel disease
Drugs affecting intestinal secretions
What are examples of drugs for acid suppression?
H2 receptor antagonists
Proton pump inhibitors
What are examples of drugs affecting GI motility?
What are examples of drugs for IBD?
What are examples of drugs affecting intestinal secretions?
Bile acid sequestrants
What do antacids contain?
Magnesium or aluminium
What do antacids do?
Neutralise gastric acid
When are antacids taken?
When symptoms occur
What is an example of an alginate?
What is an alginate?
Form of viscous gel that floats on stomach contents and reduces influx
How do H2 receptor antagonists work?
Block histamine receptor therby reducing acid secretion
How are H2 receptor antagonists administered?
Orally or IV
What is an example of a H2 receptor antagonist?
What is an example of a proton pump inhibitor?
When are H2 receptor antagonists indicated?
Peptic ulcer disease
How do proton pump inhibitors work?
Block proton pump and therby reduce acid secretion
When are proton pump inhibitors indicated?
Peptic ulcer disease
How are proton pump inhibitors administered?
Oral or IV
What are side effects of proton pump inhibitors?
Predisposition to C. Difficile infection
What do prokinetic agents do?
Increase gut motility and gastric emptying
What are examples of prokinetics?
Anti-emetics such as Metoclopramide and Domperidone
What is the mechanism of action of prokinetic agents?
Not clear but involves parasympathetic nervous sytem control of smooth muscle and sphincter tone (via acetylcholine)
What is the mechanism of action for Domperidone?
Blocks dopamine receptors which inhibit post-synaptic cholinergic neurones
What is the physiology behind vomiting?
What different things can be targeted to prevent vomiting?
Chemoreceptor trigger zone
Pharynx and GIT
What is a possible side effect of drugs that decrease motility?
What are examples of drugs that decrease motility?
What is the clinical benefit of drugs that reduce motility?
What is the mechanism of action of drugs that decrease motility?
Decrease smooth muscle contraction, increase anal sphincter tone
What are anti-spasmodics used for?
Reduce symptoms due to IBS or renal colic