COPD Intro Flashcards

1
Q

What IS COPD
A _____and _______disease
Characterized by __________ airflow limitation (obstruction)
Is not fully _______
Associated with an abnormal _________ of the lungs to noxious particles or gas.

A

treatable and preventable
progressive

reversible
abnormal inflamm response

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2
Q
Chronic Bronchitis (CB)
Inflammation of bronchioles
A

● Defined clinically
● a chronic productive cough
● for at least 3 months in each 2 successive years
● other causes of chronic cough have been
excluded

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3
Q

Emphysema (E)

Destruction of alveoli

A

● Defined anatomically
● Abnormal permanent enlargement of the
airspaces distal to the terminal bronchioles
● accompanied by destruction of their walls and
without obvious fibrosis

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4
Q

Chronic Bronchitis (CB) pathophys

Chronic inflammation
understand

A

● Cigarette smoke damages epithelial cells
● Tissue damage attracts inflammatory cells 
release enzymes  damage epithelial cells and
stimulate goblet cells to ↑ in number and to ↑
mucus production
● Airway obstruction blockage by mucus,
inflammation, progressive scarring (fibrosis),
and/or narrowing (constriction) of the airways

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5
Q

Emphysema (E) - Loss of elastic recoil

understand

A

● Cigarette smoke attracts inflammatory cells
(WBC, including neutrophils, lymphocytes, and
macrophages) into the lung
● Inflammatory cells release proteases
proteases dissolve the proteins in the alveolar
walls (septae) and thereby destroy the septae

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6
Q

Screening: Identifying Patients with possible COPD
Spirometry is required to establish diagnosis

what is the starting question
5 questions?

A

Smoker or ex-smoker (or have history of occupational exposure to dust/chemicals) that is ≥ 40 years old

AND answer “yes” to 1 of any of the following:
- Regular cough “Do you cough regularly”
- Productive cough with sputum “Do you cough up phlegm regularly”
- SOB even from simple chores “Do even simple chores make you SOB?”
- Wheezes on exertion or at bedtime “Do you wheeze when you exert yourself or at night?”
- Frequent colds that persist longer than other people. “Do you get frequent colds that
persist longer than those of other people you know?

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7
Q

what FEV1/FVC confirms persistent airflow limitation/obstruction

A

FEV1/FVC <0.70

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8
Q

GOLD recommends assessment of 3 following factors for improving and managing COPD?

A
  1. Assess lung function (degree of airflow limitation)
  2. Assess frequency of exacerbations
  3. Assess symptom severity (mMRC dyspnea scale*/CAT)
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9
Q
  1. Classification of airflow limitation severity (obstruction of air flow- degree of airflow limitation)

o FEV1/FVC < 0.70 = COPD
o GOLD GRADE: Based on post bronchodilator FEV1

what is classified as:
mild (GOLD 1)
moderate (GOLD 2)
severe (GOLD 3)
very severe (GOLD 4)
A

GOLD 1 FEV1> 80% predicted
GOLD 2 FEV1 > 50% - <80%
GOLD 3 FEV1> 30% - <50%
GOLD 4 FEV1< 30% predicted

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10
Q
  1. Assess risk of exacerbations
A

o A thorough review of exacerbation history in the last 12 months
o > 2 exacerbations in the last 12 months OR >1 leading to hospital admission
o 0 or 1 exacerbations not leading to hospital admission

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11
Q
  1. Assess symptoms

which 2 ways to do this?

A

a) MRC dyspnea scale - useful clinical measure that better reflects overall disease impact
b) COPD Assessment Test (CAT); Classification by over-all well being
- Includes 8 statements about symptoms and activities. Patient scores each statement on a scale of 0 to 5 and the impact of COPD is assessed by the cumulative score (0-20)

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12
Q

ABC Tool for Assessment

A: low risk; less symptoms
MMRC?
CAT?
exacerbations per year?

A

either MMRC <0-1
or CAT <10

exacerbations per year: 0 or 1 not leading to hospital admission

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13
Q

ABC Tool for Assessment

B: low risk; more symptoms
MMRC?
CAT?
exacerbations per year?

A

either MMRC >/= 2
or CAT >/= 10

exacerbations per year: 0 or 1 not leading to hospital admission

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14
Q

ABC Tool for Assessment

C: high risk; less symptoms
MMRC?
CAT?
exacerbations per year?

A

either MMRC <0-1
or CAT <10

exacerbations per year: >/= 2 or >/= 1 leading to
hospital admission

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15
Q

ABC Tool for Assessment

D: high risk; more symptoms
MMRC?
CAT?
exacerbations per year?

A

either MMRC >/= 2
or CAT >/= 10

exacerbations per year: >/= 2 or >/= 1 leading to
hospital admission

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16
Q

asthma vs COPD

airway inflamm

A

asthma: eosinophilic
COPD: neutrophilic

17
Q

asthma vs COPD

response to ICS

A

a: Essential for optimal control
c: Helpful in patients with moderate to severe disease and frequent AECOPD

18
Q

asthma vs COPD

role of bronchodilators

A

a: as needed only
c: regular therapy usually necessary

19
Q

asthma vs COPD

role of exercise training

A

a: rarely formally used
c: essential therapy

20
Q

asthma vs COPD

end of life discussions

A

a: rarely necessary
c: often essential

21
Q

goals of therapy

see summary of goals table for more

A

Symptoms:
Alleviate breathlessness and other respiratory symptoms Symptoms
Improve exercise tolerance and daily activity
Improve health status

Risk:
Prevent disease progression
Reduce the frequency and severity of exacerbations
Treat exacerbations and complications of the disease
Reduce mortality

22
Q

Non-pharm

Smoking Cessation (reduce risk factors) (+/- pharmacologic interventions)

A

single most effective intervention to reduce the risk of developing COPD and only intervention shown to slow it’s progression

23
Q

Non-pharm

Education (Health Literacy)
read

A

o Tailor to individual patient
o Education alone does not improve exercise performance or lung function
o Plays a role in improving skills, ability to cope with illness, and health status
o Improves patient response to exacerbation

24
Q

Non-pharm

Rehabilitation

A

All COPD patients should be encouraged to maintain an active lifestyle:
▪ FITT: (frequency) 3-5 sessions/week, (intensity) to moderate SOB; (timing) 30- 45 min; (type of exercise) walk, cycle, swim

components: exercise, psychosocial support, nutrition counseling, occupational therapy, energy conversation strat, education

25
Q

Non-pharm

Benefits of Pulmonary rehab

A

▪ Reduce symptoms: dyspnea, exercise endurance, decrease fatigue
▪ Improve quality of life
▪ Reduced resource utilization
▪ Trend to reduced mortality compared to standard care

26
Q

Non-pharm

● Home Oxygen
when is it needed

A

Survival benefit conferred by supplemental O2 treatment in certain patients
◦ Stage IV patients with the following:
◦ PaO2 ≤ 7.3 kPa (55mmHg) or SaO2 ≤ 88% with or without hypercapnia
OR
◦ Pa O2 7.3 kPa – 8 kPa (60 mmHg) or SaO2 88% with evidence of pulmonaryhypertension, peripheral edema suggesting cardiac failure, or polycythemia (Hct >
55%)
◦ Goal is to maintain kPa > 8 and SaO2 at least 90% to preserve vital organ function

27
Q

Drugs to avoid in COPD

A
o Anti-tussives
o Sedating antihistamines
o Beta-blockers
o Opioids*
o Benzodiazepines*
*maybe used as part of end of life care
28
Q

non-pharm

vaccines
antibiotics

A

Vaccinations
o Annual influenza
▪ Reduces serious illnesses and death in COPD
o Pneumococcal x 1, repeat in 5 – 10 yrs
▪ Reduces incidence of CAP (community acquired pneumonia)

Antibiotics (area of controversy)
o continuous prophylactic use have NOT shown to reduce exacerbations
o Only use to treat infectious exacerbation of COPD and other infections