CPS: Leukemia

Question 1

4 main types of leukemias

Answer 1

AML, ALL, CML, CLL (and many others)

Question 2

arrow cell

Answer 2

blasts: obvious nucleolus, looks like a soccer ball nucleus. Clone is taking over, this slide is pretty homogenous.

Question 3

____ is a marrow-based neoplasms composed of blasts or minimally differentiated cells

Answer 3

acute leukemias. they have more blasts (% wise) than chronic leukemias

Question 4

which marrow aspirate is normal

Answer 4

the left one.

Question 5

compare AML vs ALL based on age, lymphadenopathy, splenomegaly and characteristic appearance of blasts.

Answer 5

Question 6

compare and contrast the morphology of blasts in AML vs ALL in terms of blast size, nuclear chromatin, nucleoli, cytoplasm.

Answer 6

AML also has auer rods.

Question 7

note:

Question 8

___ is often a pediatric malignancy that manigests in pancytopenia, anemia, joint and bone pain.

Answer 8

ALL

Question 10

what’s wrong with this blood smear?

Answer 10

lots of immature band neutrophils. Could be CML. Eosinophils and basophils also apparent in this slide, which is characteristic of CML–> also of myeloid lineage

Question 11

CML affects male ____ most

Answer 11

male adults more than children

Question 13

T/FCML causes pancytopenia

Answer 13

false. it causes a leukocytosis

Question 14

Does a person with CML often present with lymphadenopathy

Answer 14

no. no lymphadenopathy, but often splenomegaly.

Question 15

the philadelphia chromosome is often present in people with ___

Answer 15

CML

Question 16

what’s wrong with this blood emar

Answer 16

smudge cell (fragile lymphocytes)– person probably has CLL.

Question 17

age range for CLL?

do you see splenomegaly? do you see lymphadenopathy? what autoimmune complications are seen in people with CLL?

Answer 17

Question 18

a person with CLL presents with this blood smear and has a rising LDH and positive DAT. what does he likely have and what would you do to treat it?

Answer 18

he has an autoimmune hemolytic anemia. Can happen after leukimia treatment. Treated with prednisone.

Question 19

T/F AML manifests with pancytopenia

Answer 19

true. can cause febrile neutropenai and may require platelet and RBC transfusion.

Question 20

What is tumor lysis syndrome

Answer 20

an oncologic emergency. manifests through electrolyte abnormalities, kidney failure, and a cytokine storm

also presents with gout because the cancer cell lysis causes uric acid relase.

Question 21

treatment of TLS

Answer 21

Question 22

what condition might this person have?

Answer 22

hairy cell leukemia

Question 23

characteristics of hairy cell leukemia

Answer 23