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Infectious Disease (OSI type) > Antiprotozoal > Flashcards

Antiprotozoal Flashcards

1
Q

[Drugs for Amebiasis]

Tissue amebicide

A
  1. Chloroquine
  2. Emetines
  3. Metronidazole
  4. Tinidazole
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2
Q

[Drugs for Amebiasis]

Luminal amebicide

A
  1. Paromomycin
  2. Iodoquinol
  3. Diloxanide furoate
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3
Q

[Drugs for Amebiasis]

Asymptomatic, intestinal indection

A
  1. Diloxanide furoate
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4
Q

[Drugs for Amebiasis]

Mild to moderate intestinal infection

A
  1. Metronidazole PLUS

2. luminal agent

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5
Q

[Drugs for Amebiasis]

Severe intestinal infection

A
  1. Metronidazole OR tinidazole PLUS

2. Luminal agent

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6
Q

[Drugs for Amebiasis]

Hepatic abscess and other extraintestinal disease

A
  1. Metronidazole OR tinidazole

2. Luminal agent

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7
Q

[Drugs for Amebiasis]

___ inhibits protein synthesis, Blocks ribosomal movement.

A

Emetine

Back up drug only

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8
Q

[Drugs for Amebiasis]

SE: Thyroid enlargement, peripheral neuropathy, visual dysfunction

A

Iodoquinol

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9
Q

[Drugs for Amebiasis]

Reactive reduction by ferredoxin forming free radicals that disrupt ETC

A

Metronidazole

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10
Q

[Drugs for Amebiasis]

causes dark urine, leukopenia, dizziness, disulfram reaction

A

Metronidazole

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11
Q

[Drugs for Amebiasis]

used to treat asymptomatic cyst carriers

A

paromomycin

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12
Q

[Drugs for Amebiasis]

used to treat metronidazole-resistant amebiasis

A

nitazoxanide

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13
Q

[Drugs for pneumocytosis and toxoplansmosis]

___ blocks dihydropteroate synthase and dihydrofolate reductase

A

Co-trimoxazole

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14
Q

[Drugs for pneumocytosis and toxoplansmosis]

prophylaxis treatment for Pneumocytosis

A

Co-trimoxazole

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15
Q

[Drugs for pneumocytosis and toxoplansmosis]

prophylaxis for T. gondii and I. bello

A

Co-trimoxazole

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16
Q

[Drugs for pneumocytosis and toxoplansmosis]

Inhibits glycolysis or interferes with nucleic acid metabilis; back up treatment of pneumocystosis

A

pentamidine

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17
Q

[Drugs for pneumocytosis and toxoplansmosis]

can be used to treat trypanosomiasis administered via nasal spray

A

pentamidine

18
Q

What is the DOC for prophylaxis and treatment of Toxoplasmosis?

A
  1. Sulfadiazine-Pyrimethamine OR

2. Sulfadiazine- Clindamycin

19
Q

[Trypanosomiasis: Sleeping Sickness]

DOC for Early, west african

A

Pentamidine

20
Q

[Trypanosomiasis: Sleeping Sickness]

DOC for West african, wtih CNS involvement

A

Eflornithine

21
Q

[Trypanosomiasis: Sleeping Sickness]

DOC for Early, east african

A

Suramin

22
Q

[Trypanosomiasis: Sleeping Sickness]

DOC for east african, with CNS involvement

A

Melarsoprol

23
Q

DOC for african sleeping sickness, hemolypmhatic stage

A

Pentamidine

24
Q

DOC for Kala-azar prophylaxis

A

Pentamidine

25
Q

Back up drug for onchocerciasis

A

Suramin

26
Q

[Trypanosomiasis: Sleeping Sickness]

___ is a suicide inhibitor of ornithine decarboxylase

A

Eflornithine

Can cross BBB

27
Q

[Trypanosomiasis: Sleeping Sickness]

___is an organic arsenical. Inhibits enzyme sulfhydryl groups in trypanosomes

A

Melarsoprol

can cross BBB

28
Q

[Trypanosomiasis: Sleeping Sickness]

inhibit trypanothione reductase

A

nifurtimox

Back up drug for african sleeping sickness

29
Q

DOC for Chagas Disease

A

Nifurtimox

30
Q

What is the DOC for leishmaniasis except in india

A

Sodium stibogluconate

31
Q

What are the alternative drug for Kala-azar?

A
  1. Pentamidine

2. Miltefosine

32
Q

What are the alternative drug for cutaneous leishmaniasis?

A
  1. Fluconazole

2. Metronidazole

33
Q

What are the alternative drug for mucocutaneous leishmaniasis?

A
  1. Amphotericin B
34
Q

DOC for Babesia

A
  1. Clindamycin or Quinine
35
Q

DOC for Balantidium coli

A
  1. Tetracycline
36
Q

DOC for Cryptosporodium sp

A
  1. Paromomycon
37
Q

DOX for T. gondii

A
  1. Pyrimethamine + Cindamycin
38
Q

DOC for T. cruzi

A
  1. Nifurtimox
39
Q

DOX for T. gondii

A
  1. Pyrimethamine + Cindamycin
40
Q

DOC for T. cruzi

A
  1. Nifurtimox

Infectious Disease (OSI type) (24 decks)

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