Pharm Flashcards

1
Q

acetaminophen MOA

A

decrease syn of prostaglandins

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2
Q

NSAIDs

A

inhibit Cox I

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3
Q

when to stop ASA before sx

other NSAIDs

A

1 week

3-5 days

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4
Q

when should you avoid morphine

A

head trauma

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5
Q

methadone

A

opioid agonist and NMDA antag

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6
Q

beta lactams can induce this type of hypersensitivity

A

type I

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7
Q

1st gen cephs

A

skin

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8
Q

2nd gen cephs

A

Upper respiratory

PID

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9
Q

3rd gen cephs

A

pneumonia + CNS

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10
Q

vanco

A

red man syndrome, oto/nephro toxic

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11
Q

tetacycline MOA

amingoglycosides

A

30s

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12
Q

clinda MOA

macrolides

A

50s

good for PCN/ceph allergy

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13
Q

FQ MOA

A

DNA gyrase

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14
Q

Bactrim MOA

A

block folate

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15
Q

what to monitor with INH

A

monitor LFTs, give B6, drug induced lupus

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16
Q

furosemide

A

ascending loop of henle

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17
Q

Non-dihydro

A

verapamil-affects contractility
diltiazem-angina/antiarythmias
SE constipation

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18
Q

dihydro

A

amlodipine

vasodilation

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19
Q

Digoxin

A

+ inotrope, used for HF/a-fib

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20
Q

glitazones

A

BBW for MI

21
Q

what drug can be used to prevent tumor lysis syndrome

A

allopurinol

22
Q

carbamezapine SE

A

aplastic anemia, prevent Na influx

23
Q

phenytoin SE

A

gingival hyperplasia, osteoperosis, megaloblastic anemia

supplement with folate, Ca, Vit D

24
Q

what to monitor for valproate

A

LFT

25
Q

doxorubicin SE

A

cardiotoxicity

26
Q

Bleomycin

A

pulmonary fibrosis

27
Q

5-FU SE

A

mucositis

28
Q

cisplatin SE

A

peripheral neuropathy

ototoxicity

29
Q

cyclophosphamide SE

A

hemorrhagic cystitis

30
Q

adenosine and dipyramidole moa

A

vasodilation of coronary arteries

31
Q

Maoi can cause

A

HTN

32
Q

Tyrosine kinase inh are usedul for

A

CML

33
Q

Hydralazine is used in conj with

A

Isosorbide dinitritr

34
Q

HIV regimen

A

2 NRTIs + 1 other class

35
Q

argatroban

A

direct thrombin inhibitor

36
Q

clopidogrel

A

p2Y12 receptor inhibitor

37
Q

tamoxifen

A
prevent breast cancer
lowers LDL
increase bone density
increases risk for endometrial/uterine cancer
a/w increased risk of VTE
38
Q

what drugs effect warfarin

A

ketoconazole, INH, cimetidine

39
Q

drugs that cause dru induced lupus

A

procainamide, methyldopa, hydralazine

40
Q

this drug can cause depression, fatigue, insomnia, appetitie change

A

propranolol

41
Q

SE of heparin

A

osteoperosis

hyperkalemia

42
Q

thiazide diuretics can cause

A

hyponatremia

43
Q

tyramine MAO OD can lead to

A

HTN crisis

44
Q

best drug to treat hypertryglycerides

A

fibrates

however, they increase gallstone formation so use in caution w/GB disease

45
Q

lithium SE

A

hyperparathyroid, hypercalcemia, nephogenic DI, CKD, thyroid dysfunction, teratogenic

46
Q

drugs that cause QT prolongation

A

antipsychotics
FQs
macrolides

47
Q

HIT tx

A

switch to argatroban, fondaparinux

48
Q

digoxin SE

A

cardiac arrythmias
confusion
blurred vision/color
elevated K

49
Q

hypokalemia typically occurs also with

A

hypomagnesia