Cytochromes Flashcards
1
Q
Where is CYP450 located in smooth er and mt membrane?
A
sER:
- Liver
- Lung
- Intestine
- Brain
- Skin
Mt:
- Kidney
- adrenals
- Testis
- Ovary
- Placenta
2
Q
What kind of reaction is used by CYP450 for metabolism?
A
Hydroxylation
- Uses NADPH, O2, and H+
- Produces water and hydroxyl group on substrate
3
Q
What are common substrates of CYP450?
A
- Long chain FA
- steroids
- Bile salts
- Vit D
- Heme
- Pesticides
- Herbicides (Defoliants)
- Aromatic hydrocarbons
4
Q
What is the clinical significance of Arachidonic Acid and CYP450?
A
CYP450 breaks down Arachidonic Acid
Arachidonic Acid used for:
- Prostaglandins
- Thrombaxanes
- Prostacyclins
5
Q
What is a desmolase?
A
Sidechain cleavage enzyme used in cholesterol breakdown via CYP450
6
Q
Define Prodrug.
A
The true therapeutic agent is generated by the patients metabolism
