8. Evolution and Psychopathologies reading Flashcards

1
Q

how is the mind amazing but what is just as extraordinary?

A

The mind is amazing can remember hundreds if not thousands of faces ect. But just as extraordinary is its vulnerabilities.

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2
Q

what like the body was the brain shaped by?

A

There was never a plan for the brain, like every other part of the body it was shaped by natural selection.

Genetic variations in ancestors caused differences in brains that caused differences in behaviour which influenced how many children they produced. The result is brains with extraordinary capabilities but many vulnerabilities.

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3
Q

what can we maybe compare mental illness to?

A

normal illness

Principle with illness sometimes to serve good functioning e.g. vomiting or a temperature

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4
Q

what two hypotheses exist for mental health?

A

1) Mismatch: our bodies are unprepared to cope with modern environments
2) Trade-offs: everything in the body has advantages and disadvantages ie. Reproduction: natural selection maximises reproduction not health e.g. defensive responses: responses such as pain and anxiety are useful in the face of threats

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5
Q

what are misconceptions about emotions?

A

Several obstacles make understanding emotions difficult. Failing to recognise that negative emotions are useful is a big one. Another is failing to realise that emotions were shaped to benefit our genes and not us.

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6
Q

what are emotions part of and their functions?

A

Emotions are not part of a designed system- each emotion does not have one sole function but each has many functions and functions are served by multiple emotions.

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7
Q

what is an example of an emotion that is horrible but necessary

A

e.g. the emotion of jealousy is horrible and causes a huge amount of issue Buss reports that 13% of all homicides are committed by a spouse much of which are jealously driven. Point remains that evolution doesn’t care about feelings it cares about passing on genes. Two males one jealous one not- the partner strays. The mellow one may live a happier life but more chance of partner getting pregnant by another and thus loosing time whilst pregnant/ breast feeding before fertile again. The jealous individual has a greater reproductive success.

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8
Q

what theory explains anxiety?

A

Smoke detector principle

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9
Q

what is the smoke detector principle

A
  • individuals with a capacity for anxiety are more likely to escape from dangerous situations in a present moment and avoid them in the future.
  • just like immunity anxiety is needed like immunity is needed to but with too but immunity comes disease of its own- the same is the case with anxiety.
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10
Q

but what question needs to be asked about anxiety?

A

why is it so often excessive?

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11
Q

So why is anxiety so excessive?

A

Smoke detector principle explains a lot of useless anxiety. Systems that regulate protective responses e.g. vomiting and pain turn on the response whenever the benefits are greater than the costs, even if that results in false alarms. The costs of such responses tend to be low compared to the benefits of avoiding danger.

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12
Q

common anxiety disorders- what do they correspond to?

A

Indeed different common anxiety orders seem to correspond with good reason to different kinds of dangerous situations: e.g. phobia of small animals= fear of damage from animal, panic attacks= possible attack from predator or human, social anxiety= loss of social standing, fear of heights= fear of falling (Marks & Nesse. Fear and Fitness)

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13
Q

argument that fear is not innate though and experiment to support

A

A few fears are built in automatic responses, but most common fears are not exactly innate. Fear of snakes is not built in but the brain is prewired to learn it fast- Mineka et al., in 1970s
• Young lab-raised monkeys reach across a toy snake to get a treat
• But post watching one video of another monkey withdrawing in fright from the same toy snake created an enduring fear.
• Watching a monkey withdraw from a flower created no similar fear
• The brain seems prepared to learn to fear some cues much faster than to others.

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14
Q

what type of learning is a fear of snakes and why is this useful?

A

This is social learning of the most useful sort. Instead of a system that responds to only a few rigid cues, natural selection shaped a system that uses information from other individuals. Such fears can be transmitted from generation to generation.

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15
Q

in terms of anxiety what is the worst failure?

A

“ Few failures…are as unforgiving as failure to avoid a predator; being killed greatly decreases future fitness” Lima and Dill 1990

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16
Q

What are the effects for treatment of anxiety? Very generally

A

Understanding the Understanding the evolutionary origins and functions of anxiety does not suggest a special evolutionary kind of treatment, but, it nonetheless transforms Treatment.

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17
Q

What are the effects for treatment of anxiety? More specifically

A

Arguments about whether GAD And social anxiety disorder or fundamentally the same or different or unnecessary all are anxiety subtypes Each partially differentiated from ancestral precursor states to cope with dangers in different kinds of situations. Instead of seeking special explanations why some people have more than one anxiety disorder The Association of multiple kinds of anxiety types makes sense in light of the common evolutionary origins.
And evolution review also encourages setting aside abstract debate about whether anxiety disorders are mostly physical or mostly psychological and having attention instead to a personalised assessment of a possible causes of an individual’s anxiety.

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18
Q

how do evolutionary explanations for anxiety illuminate how treatments work

A

And evolutionary perspective also illuminates how treatments work. Antianxiety drugs do not correct a neurotransmitter deficit; they disrupt the anxiety system either and pieces. Behaviour therapy also changes the brain. The taxi via mechanisms that evolved to adjust anxiety responses on that or more dangerous. He is mechanism. Instead exposure therapy creates new inhibitory impulses from the frontal lobes that descend and prevent anxiety signals from getting to consciousness (Milad et al., 2006)

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19
Q

what are mood regulation systems vulnerable to and what can these be compared to?

A

vulnerable to Failure for the same evolution reasons of the body systems. Sometimes the failure is only apparent. Sometimes it is because of living in a modern environment. Sometimes it reflects trade-offs or the limits of what natural selection can do each deserves consideration.

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20
Q

how can the smoke detector principle explain normal mood?

A

The smoke detector principal explained some normal but nonetheless excessive mood responses. Low mood conserve calories and avoids Risk. High mood is expensive and can be dangerous. When outcomes are hard to predict, airing on the side of low mood and a provide advantageous especially in harsh environments.

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21
Q

how can an EP view of depression change approaches to treatment?

A

Understanding low mood as a useful response and depression as excessive low mood Suggest different approaches to treatment. Depression is caused by the situation, the view of the situation, and the brain. Treatment can change the situation, the view of the situation, and the brain. However, all three interact in tangled webs of causes, so addressing only one of them will miss many treatment possibilities.

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22
Q

how can an EP view of depression change understanding of how anti-depressants work?

A

This view has implications for understanding how antidepressants work. The idea that they normalise a chemical imbalance is appealing and helps to justify drug ticket but there is no evidence for any specific chemical abnormality specific to depression. It seems more likely that antidepressants do use of Physic pain what analgesics Do use of physical pain-they Disrupt a normal response system. People have wanted her antidepressants with effects on different brain chemicals all can be effective. There is no mystery here Aspirin ibuprofens and morphine all at once somewhat different things to do in the pain regulation mechanism. Different antidepressant act on different links in the new regulation system.

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23
Q

what are vulnerabilities to eating disorders influenced by?

A

Vulnerability to eating so this is influenced by genetic factors. If one twin has anorexia nervosa that the twins risk is much higher if they are identical twins with identical genes rather than fraternal twins for two different eggs. About half of individual differences in vulnerability contributed to genetic differences (Kaye et al.,2013).

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24
Q

but rather than genetically caused what can be said about eating disorders?

A

This makes eating disorders seems like a genetic disease caused by abnormal genes but it actually implicates rapidly changing environments (Weiss, 2008) Abnormal genes Causing serious eating problems would’ve been selected out. The alleles That influence the rest for me disorders are mostly genetic quirks That cause problems only in novel environments.

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25
Q

what are eating disorders a disorder of?

A

Like smoking substance abuse and obviously anorexia is a disorder of modern environments and most alleles That influence that are homeless variations in the natural environment.

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26
Q

recent study into genome of those with annorexia

A

A recent study analysed over 3400 anorexia nervosa cases, surveying the entire genome. It’s found one location in the entire genome that increased The risk of anorexia but the finding is not exactly a smoking gun. The allele is present in 48% of cases but also in 44% of controls and it increases the risk of AN by only 20% (Duncan, 2017). Eating disorders are not caused by abnormal genes They are caused by normal genes interacting with abnormal environments.

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27
Q

who proposed possible evolutionary benefit to eating disorders and what did they propose?

A

Evolutionary psychologists have proposed possible benefits from eating disorders. Surbey Noted that the cessation of the menstrual cycle in AN could postpone reproduction when times are bad (1987). Like many other species humans have mechanisms that turn off reproduction when available calories are insufficient to support a successful pregnancy (Ellison, 2003). The system monitors must only fat changes of energy availability. When weight declines rapidly, or When exercise is as extreme as that by ballet dancers or marathon runners, the mechanism turns off fertility even if bodyweight is normal.

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28
Q

what is the issue for the suggestion that there are possible evolutionary benefits to eating disorders?

A

The amenorrhea in anorexics Is indeed a product of a useful system, but reproduction Turns off by it self when food is scarce; there is no need to stop eating.

29
Q

what do some suggest as an explanation for anorexia instead of evolutionary benefits?

A

Other evolution of psychologists suggest that anorexia maybe an extreme female strategy to compete for mates. This man wants and women and women get thinner to be the winner (Abed, 1998).

30
Q

what are issues with the idea that anorexia is extreme female competition

A

men generally prefer shapes of typical young fertile Women, but those shapes include substantial breasts, thigh, and buttock fat, Nothing like the skin and bones of anorexia (singh 1993). More damning for the hypothesis, most anorexics don’t seem to be on the hunt for a man, many are not interested in sex and they do not have very many children.

31
Q

but what are criticisms of anorexia as an extreme female strategy missing out on?

A

• Those who view anorexia as a product of sexual competition do Not assume that anorexia itself is an adaptation. Most note Only this extreme competitive strategies to get mail is often overshoot. It seems possible-the rate of anorexia Is 10 times higher for women than for men.

32
Q

what three diseases show cliff-edged fitness

A

According to Nesse, 2018 (Good reasons for bad feelings)

Schizophrenia
Autism and Bipolar

33
Q

what is schizophrenia

A

Schizophrenia is a cognitive collapse in which every event is imbued with excess personal meaning and the inability to separate inner life from outer Life gives rise to hallucinations and delusions.

34
Q

what is autism?

A

Autism is manifested in early childhood by lack of social connectedness and solitary Preoccupation with repeated emotions and nonsocial thinking.

35
Q

what is bipolar?

A

Bipolar disease is the product of a broken motor stop that causes alternating periods of depression and mania.

36
Q

why is an evolutionary perspective especially useful for studying autism, bipolar and schizophrenia?

A

These are dire diseases. Despite their differences these diseases have overlapping features which makes an evolutionary perspective especially useful. Each reflects approximately 1% of populations worldwide. Each has multiples that affect 2 to 5% of people. Vulnerability depends overwhelmingly on what genes person has, but people with schizophrenia autism have fewer children than other people.

37
Q

what is the evolutionary question for bipolar, autism and schizophrenia?

A

The Evolutionary question is obvious-why hasn’t natural selection illuminated by genetic variation is causing these diseases? The evidence for genetic causes a struggle

38
Q

genetic variations and risk for schizophrenia stat

A

Genetic variations explain about 80% of schizophrenia (Sullivan and Allen ,2004)

39
Q

genetic variations and risk for bipolar stat

A

Genetic variations explain about 70% of the risk of bipolar disorder ( Smoller and Finn,2003).

40
Q

genetic variations and risk for autism stat

A

Genetic variations explain about 50% of autism.(Sandin et al., 2014).

41
Q

twin stat for autism, bipolar and schizophrenia

A

Having an identical twin with one of these disease increases the risk of over 50% Kendler et al., 2000

42
Q

but what is the issue with genetics and bipolar/ schizophrenia/ autism?

A

But it seems that no specific gene is the cause of these.

43
Q

study for not being able to find genes to explain bipolar/ autism / schizophrenia

A

The entire genome has been scoured for specific genes. Research that looked at markers spread over all 23 chromosomes to see if variations at certain locations were more common in people with these diseases that we were on other people. The conclusion was firm, there are no common genetic variations that substantially increase the risk of schizophrenia, autism, or bipolar disease (Anttila et al., 2016; Kendler, 2013). Some increase the risk, but almost all by less than 1%.

44
Q

give e.g. of disease with clear genetic effects

A

Some genetic disorders are caused by specific genetic mutations with big Effects. Poor disease such as cystic fibrosis caused by recessive genes, you get the disease if you have two copies of a defective allele.

45
Q

what is the difference between cystic fibrosis and most other diseases? give some e.g.’s

A

However, most common genetic diseases are very different. Instead of a few identifiable genetic variations with big effects, they Are caused by Thousands of variations spread across the genome, each with only a tiny effect. This is not the case only for schizophrenia autism and bipolar disease but also for Type II diabetes blood pressure and obesity to name a few. this is called the problem of missing heritability.

46
Q

quote abut individual gene variants for explaining disorders.

A

Kendler (2013) has said “ despite our wishing so, Individual gene variants of large effect appear to have a small to non-existent role in the aetiology of major psychiatric disorders. In hindsight, this should not of been surprising Natural selection tends to eliminate alleles that cause dire illness.

47
Q

what does it seem genetics is doing in terms of risk to schizophrenia/ autism/ bipolar?

A

It seems that disease risk is influenced by variations in thousands of genes with tiny affects interacting with one another and the environment.

48
Q

what does the mechanics model of the brain suggest?

A

. The mechanics model assumes that the brain is constructed of discrete circuits with specific functions with specific functions. It assumes specific disorders that can be defined By specific identifiable brain pathology With specific genetic causes. It assumes that normal grains are made by normal genomes And abnormal brains are products Of abnormal genes.

49
Q

what is the suggestion that’s not the mechanics model that seems more likely

A

A deeper evolutionary perspective Suggests the need to embrace the reality of organic complexity and look for causes Not just in mechanisms but in trade-offs that cause intrinsic vulnerabilities. Instead of just looking for broken parts And the causes of disease in some individuals, we can also ask why all members of our species are vulnerable.

50
Q

why must disorders such as autism/ bipolar/ schizophrenia not have been cut out of the gene pool?

A

The huge fitness costs of these diseases has inspired suggestions that their symptoms, or the alleles that cause them must offer selective advantages.

51
Q

who developed the Shaman hypothesis of schizophrenia?

A

One idea is that schizophrenics become Sharmans or charismatic leaders and the resulting status Get them extra matings (Stevens, 2000)

52
Q

what is the Shaman hypothesis at odds with?

A

This is inconsistent with data showing that people with these diseases have reduced number of children with her recent report suggests that people would create a trade related to schizophrenia may have increased mating opportunities (Nettle and Clegg, 2006)

53
Q

what thus seems more likely as an explaination for schizophrenia

A

More plausible possibility is that the same genetic tendency is to make a disorder likely also give up advantages. T

54
Q

possible pros to bipolar?

A

he Association of creativity and intelligence with bipolar disorder has spurred enormous interest and many studies (Greenwood 2016)

Several new studies support the idea that associated benefits preserve alleles that increase vulnerability. A study of twins found that the likelihood of Developing Bipolar disorder is associated with higher than average levels of sociality and Verbal skills (Higier , 2014)

55
Q

possible pros to autism?

A

Polinanti and Gelernter, 2017 found that alleles that increase the risk of autism spectrum disorder have been subject to positive selection, presumably because they give cognitive benefits.

56
Q

verbal ability and schizophrenia study?

A

Another study found that the amount of protein made by genes related to schizophrenia was related to verbal learning ability (Borg et al., 2016)

57
Q

how does Nesse explain the three examples of bi-polar, schizophrenia and autism?

A

cliff-edged fitness

58
Q

evidence supporting bipolar as cliff edged

A

Akiskal et al., 2003, 2007- Have showed that full-fledged bipolar illness is just the tip of a spectrum of moods instability disorders. Modern versions of mood instability maybe common because they increase reproductive success on average over the long run despite their malign effects on health for some people. This could be because productivity during burst of manic energy or because such individuals get more sex partners.

59
Q

what was cliffed edged fitness based on?

A

Based on findings of Lack (1854;1957) Who wondered why birds Didn’t lay more eggs in order to have more offspring and suspected that additional eggs With sometimes pay off But sometimes result in fewer total surviving Offspring. To test this idea he moved eggs from one nest to others. As he suspected, adding one egg to a nest Increased the number of fledgelings hatched somewhat on average, but to beyond a certain number Added eggs Decreased the total number of chicks fledged

60
Q

what are the two models of a fitness landscape

A

standard and cliff edged

61
Q

what is the standard model of a fitness landscape

A

For fitness landscapes can have a standard model i.e. bell curve shape For example rabbits with medium levels of cautiousness of the highest fitness so selection shapes the population mean to the peak, where fitness for genes and individuals coincides with maximum health.

62
Q

describe the cliff edged model of a fitness landscape

A

However, fitness landscape can be a symmetrical. Sometimes fitness increases as a trait is pushed in One Direction, but going one step too far results in going off the cliff just like the bird nest that had one egg to many.

63
Q

what is an e.g. of cliff edged fitness that humans have induced?

A

breeding fast horses and leg breaking

64
Q

how does cliff edged fitness model fit in well with schizophrenia

A

This model fits well with the idea that schizophrenia is intimately related to language and cognitive ability. It also fits well with the observation that schizophrenia may be intimately related to human capacity for theory of mind, or ability to intuit other peoples motives and cognitive abilities in general.

65
Q

what would we predict diseases resulting from cliff edged fitness to look like?

A

Diseases resulting from cliff edge fitness should be highly heritable, Observed a few percent of the population, and the rest will be influenced by the complex interactions of many normal alleles that have about the same small influence on disease risk. This matches the data for many diseases.

66
Q

in cliff edged models what do problems result from?

A

In cliff-edged models, the problem Results not From defective genes but from steep slopes on fitness landscapes that result from intrinsic trade-offs.

67
Q

what does considering cliff-edged fitness landscapes encourage

A

Considering cliff-edged fitness landscapes encourages looking for traits and trade offs that may be crucial for explaining dire disease.

68
Q

what is a biological e.g. in humans of cliff edged fitness

A

E.g of babies head as cliff edged fitness.