Treatment Flashcards
Learn drug classifications and names
What is the cheapest, most effective and best tolerated drug therapy to manage Parkinson’s?
Sinemet and Madopar: Levodopa, combined with dopa decarboxylase inhibitor (DDI)
What is levodopa most effective at relieving in Parkinson’s?
Akinesia and rigidity
What are adverse effects of levodopa?
Postural hypotension, nausea, vomiting, hallucinations, abnormal behavior (only due to excessive dose),
How can complex (motor) fluctuations be managed in Parkinson’s?
Oral, dermal, transdermal, subcutaneous: Dopamine agonists
Infusions of subcutaneous apomorphine
Catechol-O-methyl transferase inhibitors (entcapone, tolcapone)
What are adverse effects of dopamine agonists?
Fibrosis, nausea, vomiting, hallucinations, impulse control disorders
What is an early treatment drug used in managing Parkinson’s (other than LD)?
Selegiline and rasagiline: Monoamine oxidase inhibitors
What is the function of Monoamine oxidase inhibitors?
To inhibit breakdown of excess dopamine in the synapse
What is the function of catechol-O-methyl transferase inhibitors?
Inhibit peripheral breakdown of LD
How are LD-induced dyskinesias managed?
Amantadine
How can tremor sometimes be managed in Parkinson’s?
Anti-cholinergics
What are adverse effects of anti-cholinergics?
Dry mouth, blurred vision, constipation, urinary retention, confusion, hallucinations
What is the name of the surgery used to manage Parksinon’s?
Stereotactic surgery with deep brain stimulation (DBS) - reserved for motor fluctuations and or medically refractory tremor
What are non-medical managements of Parkinson’s?
Occupational therapy
Physiotherapy
Speech therapy
