Lichen planus Flashcards

1
Q

the 5 skin variants of LP

A

Hypertrophic LP

Follicular LP

Vesicular LP

Actinicus LP

Ulcerative LP

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2
Q

What type of immune cell infiltrate is in lichen planus

A

CD8 mostly

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3
Q

What is the characteristic lymphocytic infiltrative pattern?

A

Sawtooth lymphocyte infiltrate at the dermal epidermal junction.

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4
Q

What are the oral lesions like in LP

A

Reticular - Whickham stria white lines

Erosive or ulcerative - superficial erosions, desquamative gingivitis.

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5
Q

How does LP affect the hair on its patches, how does this differ from psoriasis

A

LP causes scarring alopecia on the scalp, psoriasis does not cause hair loss.

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6
Q

Nail changes

A

Nail destruction with longitudinal splintering

Sometimes nails are the only part involved in lP, with all 20 involved and no other symptoms.

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7
Q

What is the histology changes of LP.

What disease does it share a similarity with?

A

Hyperkeratosis and hypergranulosis. Mild parakeratosis is also possible.

Liquifactive necrosis in the basal cell layer.
- Basal cell degeneration and vacuolization is also seen in SLE skin lesions.

Sawtooth infiltration of mostly CD8 lymphocytes.
Band-like infiltration of mononuclear cells.

Depostis of fibrin and IgM.

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8
Q

What systemic diseases are LP associated with?

A

Mainly Hepatitis C

Also lichenoid GVHD and lichenoid drug eruptions

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9
Q

Treatment of LP

A

Topical glucocorticoids
Topical cyclosporine and tacrolimus

Oral cyclosporine or glucocorticoids

PUVA

Myucophenolate, Azathiaprine.

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