Liver Pathology Flashcards

1
Q

Acinar zones

A

1 - periportal
2 - midzonall
3 - centrilobular (most likely to get ischemia)

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2
Q

Necorsis in the liver

A

Acidophil bodies - apoptosis

Zonal necrosis - centriblobular is most common
Midzonal for yellow fever
Periportal for phosphorus

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3
Q

Causes of centrilobular necrosis of the liver

A

Hypotension
CHF
Drug toxicity (tylenol)

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4
Q

Mech of acetominophen OD

A

Acet normal excreted as glucouronate and sulfate

Alcoholics havbe more CYP2E1…convert to NAPQI…less glutathione

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5
Q

Interface hepatitis

A
Hep C
Hep B 
AI hep
Primary biliary and scelorising cholangitis 
alpha 1 AT
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6
Q

Cirrhosis

A

Diffuse, bridging fibrosis and regenerating nodules

Could be from alcoholic liver dz
Hep B or C (C more common)
NAFLD

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7
Q

CM of cirrhosis

A

IMpaired hepatic metab of estrogen

Impaired synthesis of albumin and coagulation

Hepatorenal syndrome

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8
Q

FLD etiologies

A

Alcoholic

Non alcoholic from obesit yor T2DM

See fatty liver
Steatohepatitis - alcoholic or NASH
cirrhosis

Occur sequentuially

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9
Q

Drug and toxin induced liver injury

A

Indistinuishable from other etiologies

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10
Q

Echinacea

A

Herbs that supposedly increase immune system

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11
Q

Green tea extract

A

Smarter, burn fat, antioixdants

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