inflammatory extra Flashcards

1
Q

what are blood test markers seen with SLE?

A

ESR elevated
+ ANA
+ RF

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2
Q

steroids used with SLE may lead to what clinically significant signs?

A

osteoporosis
AVN
spinal fractures
gastric ulcerations

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3
Q

what is the most frequent and serious complication of SLE?

A

kidney involvement leading to nephropathy and renal failure

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4
Q

What conditions can you see increased ADI?

A

JRA- most likely
RA
SLE- 8.5%

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5
Q

what conditions present with ulnar deviation?

A

SLE
Jaccouds
RA

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6
Q

What is the SLE distribution in the hands?

A

MCP and PIP MC
reversible ligament laxity- ulnar deviation
swan neck and boutonniere deformity

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7
Q

If a patient has ulnar deviation with minimal joint disease what is the most likely cause?

A

SLE

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8
Q

which disorder follows rheumatic fever, streptococcal pharyngitis and other CT disorders?

A

Jaccoud’s arthropathy

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9
Q

what presents with arthralgia, myalgia, weight loss, mitral valve disease?

A

Jaccoud’s arthropathy

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10
Q

With Jaccoud’s arthropathy there is no synovial pathology only _____ or _______

A

capsular fibrosis or DJD

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11
Q

scleroderma is the cutaneous manifestation of what disease?

A

progressive systemic sclerosis

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12
Q

dysphagia and heartburn are seen in 90% of patients with?

A

scleroderma

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13
Q

bowel sluggishness, distention, constipation and fibrosis in the lungs are seen with what condition?

A

scleroderma

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14
Q

calcinosis and acro-osteolysis are seen with which condition?

A

scleroderma

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15
Q

what is a chronic inflammatory disorder most commonly affecting young males primarily affecting the axial skeleton?

A

AS- chronic LBP in males

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16
Q

what condition is characterized by sequela of articular ankylosis, ligamentous ossification and enthesopathic changes?

A

AS

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17
Q

50% of AS patients will have peripheral disease especially affecting hips and shoulders, what is this called?

A

spondylitis rhizomelique

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18
Q

what percent of AS patients are + HLA-B27?

A

90%

19
Q

how does AS typically affect the spine?

A

SI joint initially, then into the thoracolumbar jx, then lumbosacral and develops into ascending phenomenon

20
Q

reactive sclerosis seen with AS is known as what radiographically?

A

shiny corner sign

21
Q

corner erosions from reactive sclerosis seen in AS is known radiographically as?

A

romanus lesions

22
Q

what is dagger sign?

A

interspinous ligament calcification- AS

23
Q

what is trolley track sign?

A

z-joint capsular ossification- AS

24
Q

what are vertically oriented spurs that are ossification of outer annulus fibers and inner ALL fibers?

A

syndesmophytes

25
Q

vertebral body squaring is seen in?

A

AS

26
Q

who does psoriatic arthritis typically affect?

A

10-15% of those with psoriasis

30-50 yrs old no gender bias

27
Q

axial skeleton involvement in what percent of psoriatic arthritis?

A

20-40%

28
Q

how does psoriatic arthritis usually present in hands?

A

asymmetrical small joint involvement, mostly DIP
mouse ears
pencil and cup
sausage digit

29
Q

psoriatic mimics RA but is _____

A

less symmetric

30
Q

spinal changes with psoriatic mimic AS but have ______

A

bulkier syndesmophytes and non-marginal

bilateral asymmetric

31
Q

Reiters is usually caused by what?

A

STI-chlamydia
previous GI infection

usually 1-3 weeks post infection

32
Q

what population is usually affected by Reiter’s?

A

males 15-35

33
Q

what is the classic triad of Reactive arthritis?

A

conjunctivitis
urethritis
arthritis

though few demonstrate all 3

34
Q

how does Reactive arthritis present in the SI joint?

A

asymmetric or unilateral

35
Q

how does reactive arthritis present in the spine?

A

thick, non marginal syndesmophytes

36
Q

what is lovers heel seen with reiters?

A

enthesopathy at plantar fascia and achille’s insertions into calcaneus; MTP also involved

37
Q

sx before what age with CPPD are uncommon?

A

age 50

38
Q

what are the metabolic disease associations with CPPD?

A
hemochromatosis 
hyperparathyroidism
gout
diabetes mellitus 
DJD
39
Q

what are the 3 C’s of chondrocalcinosis?

A

Cartilage degeneration- DJD
Crystal deposition- gout CPPD
Cation disease- wilsons, hemochromatosis, hyperparathyroidism

40
Q

when articular alterations occur secondary to cartilage degeneration what results?

A

pyrophosphate arthropathy

41
Q

what is the MC genetic disorder affecting 1 in 300 people?

A

hemochromatosis- males 20:1 40-60

42
Q

what is the triad seen in hemochromatosis

A

bronze skin
cirrhosis
diabetes

43
Q

hooked osteophytes and chondrocalcinosis usually at MCP is seen in?

A

hemochromatosis