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KMK - Ocular Disease > Anterior Uveitis > Flashcards

Anterior Uveitis Flashcards

1
Q

Uveitis typically occurs in what age range?

A

Young adults (2nd-4th decade)

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2
Q

Uveitis generally only occurs in adults over 70 if associated with what 2 things?

A

Toxoplasmosis

Herpes zoster

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3
Q

Uveitis occurs secondary to what?

A

Breakdown of the blood-aqueous barrier

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4
Q

What are the 3 locations of the blood aqueous barrier?

A
  1. Non-pigmented ciliary epithelium (NPCE)
  2. Iris vessels
  3. Schlemm’s canal
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5
Q

50% of patients with acute anterior uveitis are positive for what gene?

A

HLA-B27

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6
Q

What conditions are associated with the HLA-B27 gene?

A 
(CRAP)
Crohn's
Reactive arthritis
Ankylosing spondylitis
Psoriatic arthritis
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7
Q

What are the two types of anterior uveitis?

A

Acute, non-granulomatous

Chronic, granulomatous (bilateral)

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8
Q

What is the most common systemic cause of anterior, acute, non-granulomatous uveitis?

A

Ankylosing spondylitis

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9
Q

Chronic, bilateral, granulomatous uveitis is commonly associated with what 3 conditions?

A

Sarcoid
TB
Syphilis

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10
Q

Keratic precipitates are commonly found in which type of anterior uveitis?

A

Chronic, granulomatous

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11
Q

Rank the types of uveitis from most common to least common.

A
  1. Anterior uveitis (iritis, iridocyclitis)
  2. Posterior or panuveitis
  3. Intermediate (pars planitis)
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12
Q

Stellate KPs are commonly seen in what two conditions?

A

Fuch’s heterochromic iritis

Herpes

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13
Q

What are the common symptoms of uveitis?

A 
Pain
Redness
Photophobia
Lacrimation
Mildly decreased VA (especially with CME)
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14
Q

Which nerves are causing the pain in anterior uveitis?

A

Anterior ciliary nerves

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15
Q

What are the common signs of anterior uveitis?

A 
WBCs in the anterior chamber
Flare
Hypopyon
Circumlimbal injection
IOP elevation (early stages)
KPs
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16
Q

IOP may be decrease during which stages of uveitis, and in which eye?

A

Early stages

Affected eye

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17
Q

What are the main threats to vision in uveitis?

A

PAS
PS
CME
Cataract formation

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18
Q

What type of cataract is common in anterior uveitis?

A

PSC

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19
Q

Why might IOP increase in the affected eye in the later stages of uveitis?

A

PAS or PS formation

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20
Q

Fine KPs are characteristic of (granulomatous/non-granulomatous) etiology.

A

Non-granulomatous

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21
Q

Granulomatous etiology of uveitis is more common with what cause?

A

Infection (TB, syphilis)

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22
Q

What iris nodules may be found in granulomatous uveitis?

A

Koeppe

Busacca

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23
Q

In what layer of the iris are Koeppe and Busacca nodules found?

A

Iris stroma

24
Q

What make up mutton fat KPs?

A

Macrophages

25
Q

What are Koeppe nodules?

A

Collections of WBCs on the pupillary margin

26
Q

What are Busacca nodules?

A

Collections of WBCs of any part of the iris stroma that is not the pupillary margin

27
Q

Busacca nodules are pathognomonic what what etiology of uveitis?

A

Granulomatous

28
Q

Koeppe nodules are associated with which etiology of uveitis?

A

Both granulomatous and non-granulomatous

29
Q

What are the most common corneal findings in anterior uveitis?

A

KPs

30
Q

Acute, non-granulomatous, anterior uveitis is commonly associated with what 7 diseases?

A 
IBS
Reactive arthritis
Ankylosing spondylitis
Psoriatic arthritis
Behcet's disease
Lyme disease
Glaucomatocyclitis Crisis (Posner-Schlossman)
31
Q

What characterizes reactive arthritis?

A

Young males with urethritis, polyarthritis, and conjunctivitis (with iritis)

32
Q

What characterizes psoriatic arthritis?

A

Peripheral, small joint pain

Psoriatic lesions on the knees, elbows, and scalp

33
Q

What characterizes Behcet’s disease?

A

Acute, recurrent hypopyon iritis

Mouth and genital ulcers

34
Q

Chronic, granulomatous, anterior uveitis may be associated with what major 4 conditions?

A

Sarcoidosis
TB
Herpes Simplex/Zoster
Syphilis

35
Q

Sarcoidosis associated uveitis is typically (unilateral/bilateral).

A

Bilateral

36
Q

What type of uveitis is associated with sarcoidosis?

A

May be either posterior or panuveitis

37
Q

What abnormal findings are common in sarcoidosis?

A

Abnormal chest x-ray

Increased ACE levels

38
Q

What are common signs/symptoms of TB?

A

Positive PPD
Abnormal chest x-ray
Night sweats

39
Q

What type of uveitis is commonly associated with TB?

A

Posterior

Panuveitis

40
Q

Herpes simplex/zoster associated uveitis is commonly associated with increased what of the involved eye?

A

IOP

41
Q

What type of KPs may be present in herpes associated uveitis?

A

Stellate KPs

42
Q

What are common ocular findings of herpes associated uveitis?

A

KPs
Corneal edema
Epithelial defects

43
Q

What 3 things characterize syphilis?

A

Maculopapular rash of palms and/or soles
Positive VDRL or RPR
Positive FTA-ABS or MHA-TP

44
Q

Syphilis associated uveitis may have what associated corneal finding?

A

Interstitial keratitis

45
Q

What is interstitial keratitis?

A

Stromal inflammation without primary involvement of the epithelium or endothelium

46
Q

What characterizes interstitial keratitis?

A

Acute stromal inflammatory edema and neo

47
Q

What are the most common causes of interstitial keratitis?

A

Congenital syphilis
TB
Herpes simplex

48
Q

What is the triad of congenital syphilis?

A

Hutchinson’s teeth (small, spaced teeth)
Deafness
Interstitial keratitis

49
Q

Chronic, non-granulomatous, anterior uveitis may be associated with what two main conditions?

A

Juvenile idiopathic arthritis (JRA)

Fuchs’ heterochromic iridocyclitis

50
Q

What three drugs/classes can cause anterior uveitis?

A

Rifabutin
Systemic sulfonamides
Cidofovir

51
Q

What is the most common knowns cause of uveitis in kids?

A

Juvenile idiopathic arthritis

52
Q

Which gender typically gets JRA (or JIA)?

A

Young girls

53
Q

What is the classic presentation of JRA (JIA)?

A

Bilateral uveitis in young girls

54
Q

Patients with JRA (JIA) typically have what RF and ANA findings?

A

Negative RF

Positive ANA

55
Q

Fuchs’ heterochromic iridocyclitis occurs most frequently in patients with what color eyes?

A

Blue

56
Q

What characterizes Fuchs’ heterochromic iridocyclitis?

A

Unilateral, mild uveitis
Fine stellate KPs
Angle neo
Iris heterochromia

57
Q

Pars planitis is associated with what systemic conditions?

A

None - trick question!

KMK - Ocular Disease (20 decks)

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