Hematopoiesis Flashcards
Starting with Hematopoietic stem cells, state the steps to create a precursor cell.
multipotential HSC –> pluripotential stem cells Colony Forming Units (CFU-GEMM and CFU-L) –> Progenitor cells (CFU or sometimes 1st BFU) –>Precursor cells
What is the progenitor cell of erythrocytes that gives rise to CFU-E
BFU-E (burst forming unit-Erythroid)
What is CFU-GM
Colony Forming Unit- Granulocytes/Macrophages (think about neutrophils)
How is the passage of blood cells through the capillary-venous sinus endothelial layer selective?
Normally only mature cells are allowed to pass from the marrow into the sinuses and subsequently into the peripheral circulation; immature cells are retained.
Erythropoietin is made by_____
certain kidney cells in response to hypoxia
What promotes the production of eosinophils?
IL-5
What promotes the production of basophils?
IL-3
what does G-CSF stand for? It is a hematopoietic growth factor for what?
Granulocyte Colony Stimulating Factor. promotes granulopoiesis.
Name the erythroid precursors leading to an erythrocyte.
Pronormoblast–> Basophilic normoblast–>polychromatophilic normoblast–>orthochromatic normoblast–>reticulocyte–>erythrocyte
PBPORE
What are the granulocytic precursors?
myeloblast–>promyelocyte–>myelocyte–>metamyelocyte–> band–>segmented granulocyte (seg)
primary cytoplasmic granules are _____ while secondary cytoplasmic granules are _____.
azurophilic
specific
The ratio of granulocytic to erythroid precursors should be around____
3:1 This is known as the M:E ratio
