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sophie hayton
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Decks in this class (23)
Hallmarks of Cancer 1,2,3
Normal cell division is _____,
Cancer is a ______ process,
What do cancer cells develop char...
60
cards
Introduction to molecular therapies
Side effects of standard cancer t...,
What drug is gleevex,
Imatinib moa
14
cards
Oncogenes
Tf oncogenes are recessive,
Tumour suppressor genes are divid...,
In haploid sufficient genes why i...
34
cards
Enabling replicative immortality
Name of the 2 strands for dna rep...,
What is the lagging strand made u...,
What happens to the dna at the en...
21
cards
Evasion of growth suppressors
Tumour supressor genes encode what,
What can happen to tsgs to allow ...,
Tsgs need to be inactivated where...
32
cards
Sustaining proliferative signals
What is the cell cycle stimulated by,
Which extracellular signals induc...,
How many phases is the cell cycle...
53
cards
Kinases as molecular targets
________ of proteins and lipids a...,
What catalyses phosphorylation an...,
Changes in levels and activities ...
15
cards
EGFR targeting
Tf signalling through her1 2 3 4 ...,
2 egfr pathways,
Lapatinib is commonly known as a ...
19
cards
Targeting downstream of RTK's
_____ cancers overexposes her2 th...,
Over expression of egfr the ____ ...,
What is cetuximab
11
cards
Targeting DNA repair inhibitors and Systemic cell lethality
How often are dna repair pathways...,
What determines which repair path...,
Ss dna damage uses which pathway
24
cards
Therapies
How can the inflammatory system h...,
What diseases provide more of an ...,
What type of signals do inflammat...
17
cards
TMI- tumour inflammation
2 mechanisms by which tumour prom...,
Which aspects of cancer can infla...,
Cytokines produced from inflammat...
14
cards
TMI 2
What is immune oncology,
2 ways to use the immune system a...,
3 examples of oncogene activation...
14
cards
Resistance to cell death
What affects the net number of ce...,
What enzymes are the key players ...,
What does caspaces catalyse
63
cards
Avoiding immune destruction
What mouse model was evidence tha...,
What does this mouse model suppor...,
Tf macrophages are only anti tumour
42
cards
Invasion and metastasis
What is metastasis,
What systems do tumour cells migr...,
Tf cancer often involves drastic ...
43
cards
An emerging hallmark of cancer
Reprogramming of energy metabolis...,
Under oxygenated conditions how d...,
In anaerobic conditions embryogen...
75
cards
Exploiting tumour metabolism for patient benefit
Tf chemotherapy can cause metabol...,
What can metabolic changes due to...,
Tf recurring tumours in patients ...
25
cards
Obesity
1 in __ cancers are linked to obe...,
____ of breast cancers are caused...,
____ of bowel cancers are in over...
59
cards
Nuclear hormone receptors
What are the largest family of tfs,
Where is cortisol produced,
What is cortisol
73
cards
Genetic and epigenetic medicine
What does genomic medicine discov...,
Human genome has how many bases,
___ of the human genome is the sa...
44
cards
EGFR receptors- missing lecture
____ cancers overexpress her2 tha...,
Small molecule egfr approaches,
Mab approaches to egfr
16
cards
PROPER targeting downstream RTK's
What is b raf mutation key in,
What has to happen to a melanocyt...,
What of nevi will be braf mutant
18
cards
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cancer biology and therapy
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