XXI - Musculoskeletal System Flashcards Preview

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Flashcards in XXI - Musculoskeletal System Deck (141)
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91

The most common cancers that metastasize to the bone are?

Prostate, breast, kidney, and lung (TOPNOTCH)

92

What bones are most commonly involved in skeletal metastasis?

In descending order: Axial skeleton ( vertebral column, pelvis, ribs, skull, and sternum), proximal femur, and humerus (TOPNOTCH)

93

Skeletal metastases are typically multifocal, however, what carcinomas that metastasize to the bone are notorious for producing solitary lesions?

Ca of Kidney and Thyroid (TOPNOTCH)

94

Morphology: uniform oval mononuclear cells that have indistinct cell membranes and appear to grow in syncitium with scattered numerous osteoclast type giants cells having 100 or more nuclei that have identical features to those of the mononuclear cells

Giant cell Tumor (TOPNOTCH)

95

Morphology: trabeculae mimic chinese characters

Fibrous Dysplasia (TOPNOTCH)

96

Morphology: Storiform pattern or pinwheel pattern created by benign spindle cells with scattered osteoclast

Fibrous cortical defect and nonossifying fibroma (TOPNOTCH)

97

What is the primary characteristic of osteosarcoma?

The formation of bone by the tumor cells (TOPNOTCH)

98

Seen in Xray as subperiosteal resorption producing thinned cortices in the middle phalanges of the index and middle finger and loss of the lamina dura around the teeth (TOPNOTCH)

Hyperparathyroidism (Generalized osteitis fibrosa cystica or von Recklinghausen disease of the bone) (TOPNOTCH)

99

The combined picture of increased bone cell activity, peritrabecular fibrosis, and cystic brown tumors is the hallmark of what disease of abnormal mineral homeostasis?

Hyperparathyroidism (Generalized osteitis fibrosa cystica or von Recklinghausen disease of the bone) (TOPNOTCH)

100

What is the most important prognostic feature of a bone sarcoma?

Histological grade (TOPNOTCH)

101

O ring sign is seen in what cartilage forming tumor?

Chondroma (TOPNOTCH)

102

Morphology: chicken wire pattern of mineralizaton

Chondroblastoma (TOPNOTCH)

103

Myositis ossificans is distinguised from the other fibroblastic proliferations by the presence of what structure?

Metaplastic bone (TOPNOTCH)

104

Most common cause of skeletal dysplasia and a major cause of dwarfism

Achondroplasia(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1184

105

Most common inherited disorder of connective tissue

Osteogenesis Imperfecta(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1185

106

Hyaline cartilage is composed of what type of collagen?

Type II collagen(TOPNOTCH)

107

Most common type of joint disease

Osteoarthritis(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1208

108

Presents with deep, achy joint pain that worsens with use, morning stiffness, crepitus, and limitation of ROM, osteophytes(bony outgrowths), sparing of wrists, elbow, and shoulder.

Osteoarthritis(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1209

109

Radiographic hallmark of this joint disease are joint effusions and juxta-articular osteopenia with erosion and narrowing of joint space and loss of articular cartilage.

Rheumatoid arthritis(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1212

110

Presents with malaise, fatigue, and generalized musculoskeletal pain. After several weeks, may present with symmetric joint pain affecting metacarpophalangeal, PIP, wrists, ankles and knees. The lumbosacral region and hips are spared. Involved joints are swollen, warm, painful, stiif when rising in the morning or following inactivity. What is the most likely diagnosis?

Rheumatoid arthritis(TOPNOTCH)

111

It causes destruction of articular cartilage and bony ankylosis, especially of the sacroiliac and apophyseal joints. May present with lower back pain and spine immobility.

It causes destruction of articular cartilage and bony ankylosis, especially of the sacroiliac and apophyseal joints. May present with lower back pain and spine immobility.

112

Also known as rheumatoid spondylitis and Marie-Strumpell disease

Ankylosis spondylitis(TOPNOTCH)Robbins Basic Pathology, 9th ed. P. 1213

113

Triad of arthritis, non-gonococcal urethritis or cerviciis, and conjunctivitis

Reactive arthritis(TOPNOTCH)Robbins Basic Pathology, 9th ed. P. 1213

114

Presents with asymmetric pain and stiffness of the ankle and knee joints several weeks of the inciting bout of urethritis or diarrhea. May present with sausage-finger or toe, calcaneal spurs and bony outgrowths.

Reactive arthritis(TOPNOTCH)Robbins Basic Pathology, 9th ed. P. 1213

115

Chronic inflammatory arthropathy concurrently or following the onset of skin disease. Produc the characteristic "pencil in cup" deformity , due to involvement of DIP of the hands and feet in an assymetric distribution.

Psoriatic arthritis(TOPNOTCH)Robbins Basic Pathology, 9th ed. P. 1213

116

Main causative agent of infectious arthritis in children younger than 2 years old.

H. influenza(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1213

117

Main causative agent of infectious arthritis in older children and adults.

S. aureus(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1213

118

Main causative agent of infectious arthritis in patients with sickle cell disease.

Salmonella(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1213

119

Most common joint affected in nongonoccocal suppurative arthritis.

Knee(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1213

120

Presents with sudden development of acutely painful and swollen joint with decreased ROM, associated with fever, leukocytosis, and elevated ESR. Usually involves only a single joint.

Suppurative arthritis(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1213

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