Flashcards in XXI - Musculoskeletal System Deck (141)
Gross appearance: lack a medullary canal and the end of long bones are bulbous (Erlenmeyer Flask Deformity) and misshapen. The neural foramina are small and compress exiting nerves
What is the main defect in Osteopetrosis?
Deficient Osteoblastic Activity (TOPNOTCH)
Osteoporosis cannot be reliably detected in plain radiographs until how much of the bone mass is lost?
What is the histologic hallmark of Paget Disease of the bone?
Mosaic pattern of lamellar bone (Jigsaw pattern) (TOPNOTCH)
A variety of tumor and tumor like conditions develop in pagetic bone. However, what is the most dreaded complication of this condition?
Sarcoma (Osteosarcoma > Malignant Fibrous Histiocytoma, or chondrosarcoma) (TOPNOTCH)
80% of cases, what bone is involved in Paget DIsease?
Axial skeleton and proximal femur (TOPNOTCH)
What is the most common site of tuberculous osteomyelitis?
Spine (thoracic and lumbar) > knees and hips (TOPNOTCH)
Most cases of osteomyelitis reach the bone via what route?
What do you call a small intraosseous abscess that frequently involves the cortex and is walled off by reactive bone?
Brodie abscess (TOPNOTCH)
What do you call the morphologic variant of osteomyelitis that typically develops in the jaw and is associated with extensive new bone formation that obscures much of the underlying osseous structures?
Sclerosing osteomyelitis of Garre (TOPNOTCH)
What do you call a dead piece of bone?
Reactive woven or lamellar bone may be deposited and when it forms a sleeve of living tissue around a segment of devitalized bone, it is known as?
Morphology: Edematous granulation tissue containing numerous plasma cells and necrotic bone
Congenital Syphilitic Bone infection and Acquired syphillis (TOPNOTCH)
What is the most common primary malignant tumor of bone, exclusive of myeloma and lymphoma, and accounts for approximately 20% of primary bone cancers.
What are the 3 conditions associated with the development of osteosarcoma?
1. Paget disease2. Bone infarcts3. Prior irradiation (TOPNOTCH)
What part of the bone do osteosarcomas usually arise?
Metaphyseal region of the long bone of the extremities, 60% occur about the knee. (TOPNOTCH)
Morphology: Coarse, lacelike pattern of neoplastic bone produced by anaplastic malignant tumor cells
Morphology: sheets of uniform small, round cells that are slightly larger than lymphocytes with small amounts of clear cytoplasm.
Ewing Sarcoma (TOPNOTCH)
Morphology: Presence of Homer Write rosettes ( tumor cells are arranged in a circle about a central fibrillary space)
Ewing Sarcoma (TOPNOTCH)
The diagnostic cell of embryonal, alveolar, and pleomorphic variants of Rhabdomyosarcoma which contains eccentric eosinophilic granular cytoplasm rich in thick and thin filaments
Tadpole or strap cells are seen in what soft tissue tumor?
Morphology: characterized by malignant spindle cells that have cigar shaped nuclei arranged in interweaving fascicles.
Morphology: histological hallmark is the dual line of differentiation of tumor cells, epithelial like cells and spindle cells
Synovial Sarcoma (TOPNOTCH)
Gross morphology: unencapsulated, infiltrative, soft, fish flesh masses, often having areas of hemorrhage and necrosis
These cells mimic fetal fat cells and contain round clear cytoplasmic vacuoles of lipid that scallop the nucleus. Seen in liposarcoma.
Most common soft tissue tumor of adulthood.
Lipoma (TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1220
Pathognomonic hallmark of gout
What are the most common cutaneous lesions seen in RA?
Rheumatoid Nodules (TOPNOTCH)
The most important factors in the development of Osteoarthritis
Aging and mechanical effects (TOPNOTCH)