Flashcards in XIX - Female Genital System and the Breast Deck (173)
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121
Earliest lesions consist of red papules progressing to vesicles then to painful coalescent ulcers on the vulvar or vaginal area. Smears shows multinucleated squamous cellswith basophilic viral inclusion with a ground-glass appearance. This is caused by:
HSV (TOPNOTCH) Robbins Basic Pathologym 9th ed, p. 993
122
Presents with pearly, dome-shaped papules with a dimpled center. Central waxy core contains cells with cytoplasmic viral inclusion. The lesion described is:
Molluscum contagiosum(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 993
123
Manifests with vulvovaginal pruritus, erythema, swelling, and curdlike vaginal discharge. Wet KOH mount of discharge shows pseudospore or filamentous fungal hyphae.
Candidiasis(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 994
124
Presents with yellow, frothy vaginal discharge, vulvovaginal discomfort, dysuria, and dyspareunia. The vaginal and cervical mucosa typically has a fiery red appearance, with marked dilatation of cervical mucosal vessels ("strawberry cervix"). The cause is:
Trichomonas vaginalis(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 994
125
Presents with thin, green-gray, fishy vaginal discharge. Pap smear reveal squamous cells covered with a shaggy coating coccobacilli.
Bacteria vaginosis(caused by Gardnerella vaginalis)(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 994
126
This infection is characterized by marked acute inflammation of mucosa; smears of inflammatory exudate shows phagocytosed gram-negative diplococci within neutrophils.
Gonococcal infection(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 995
127
Most common site of vaginal carcinoma
Upper vagina, posterior wall at the junction with ectocervix(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1000
128
True or False: All HSILS are considered to be at high risk for progression to carcinoma.
True(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1003
129
Viral proteins implicated in the ability of HPV to act as carcinogen by interfering with the activity of tumor suppressor proteins.
E6 and E7(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1002
130
Most common histologic subtype of cervical carcinoma
Squamous Cell Carcinoma (TOPNOTCH)
131
Most common high-risk HPV type causing cervical precursor lesions and cervical carcinomas.
HPV-16.(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1007
132
Most frequent cause of dysfunctional bleeding
Anovulation(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1009
133
Disease of women in active reproductive life; causes infertility, dysmenorrhea, pelvic pain. Endometrial glands and stroma outside of the uterus.
Endometriosis (TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1012
134
An important cause of abnormal uterine bleeding; frequent precursor to endometrial carcinoma; most commonly caused by by unopposed estrogen stimulation.
Endometrial hyperplasia (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1013
135
Most common invasive cancer of the female genital tract
Endometrial carcinoma(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1013
136
True or False. Malignant transformation of leiomyoma to leiomyosarcoma is rare.
True(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1020
137
The majority of ovarian neoplasm arise from?
Mullerian epithelium(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1023
138
The most common primary malignant ovarian tumor
Serous adenocarcinoma(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1023
139
Most common germ cell tumor of the ovary in women of reproductive age
Mature cystic teratoma/dermoid cyst(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1031
140
Glomerulus-like structure composed of a central blood vessel enveloped by tumor cells within a space lined by tumor cells
Schiller-Duval body(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1031
141
Characteristic histologic feature of Yolk Sac Tumor
Schiller-Duval body(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1031
142
Ovarian tumor that may elaborate large amounts of estrogen; Two thirds occur in post-menopausal women; potentially malignant
Granulosa cell tumor(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1032
143
Biomarker useful for identifying granulosa an other sex cord-stromal tumors, and monitoring treatment.
Serum inhibin(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1032
144
Serum marker for ovarian carcinoma
CA-125(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1029
145
Ovarian tumor that often functional and commonly produce masculinization or defeminization; peak incidence 20-30 y/o; cut surface is usually solid, gray to golden brown in appearance.
Sertoli-Leydig cell tumor(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. `033
146
Most common extra-mullerian tumors metastatic to the ovary
Carcinoma of the breast and GIT(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1034
147
Systemic syndrome characterized by widespread maternal endothelial dysfunction that presents during pregnancy with hypertension, edema, and proteinuria.
Preeclampsia(TOPNOTCH) Robbins Basic Pathology, p. 1034
148
Morphology: placental infarcts, retroplacental hematoma, abnormal decidual vessels, fibrin thrombi in the portal capillaries and hemorrhagic necrosis of the liver, kidney glomeruli show marked swelling of endothelial cells, mesangial cell hyperplasia, amorphous dense deposits on the endothelial side of basement membrane.
Preeclampsia(TOPNOTCH) Robbins Basic Pathology, p. 1039
149
Choriocarcinoma is most often preceded by:
Complete H. mole(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 1041
150
