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Flashcards in Wound healing Deck (43)
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1

What are the features of first intention healing?

1. primary wound healing with primary closure
2. sutured incision
3. tissue apposition

2

what are the features of second intention healing?

1. open wound healing
2. granulation, contraction, epithelialization

3

What are the 5 sequence of wound healing

1. wounding
2. acute vascular phase (bleed)
3. inflammatory phase
4. cellular phase
5. maturation phase

4

What are the 5 sequence of wound healing

1. wounding
2. acute vascular phase (bleed)
3. inflammatory phase
4. cellular phase (fibroplasia?)
5. maturation phase (remodelling and maturation)

5

What changes occur with remodelling and maturation?

1. collagen content goes down
2. quality of collagen increases
3. cross linking between collagen occurs

6

How long does it take to return to the original tissue strength

it depends on the tissue/original tissue strength

7

What are the features of the acute vascular phase?

1. hemorrhage
2. vasoconstriction (

8

When a vessel stops bleeding during surgery, what is the cause?

vasoconstriction--the smooth muscle is traumatized and so it contracts (vasospasm) Can be assisted by pressure which helps until clot can form

9

What are the features of the inflammatory reaction of the inflammatory phase

1. localized protective response
2. elicited by injury or destruction of tissues
3. destroys, dilutes or walls of injurious agent and tissue
4. prepares wound for repair process

10

What are the vascular events of the inflammatory phase

1. cellular adhesion
2. vasodilation
3. increased vascular permeability--inflammatory exudate

11

What are the vascular events of the inflammatory phase

1. cellular adhesion
2. vasodilation
3. increased vascular permeability--inflammatory exudate

12

What are the cellular players in the inflammatory phase?

1. mast cells
2. granulocytes
3. platelets

13

What are the vasoactive substances involved in the inflammatory phase

1. histamine
2. serotonin
3. kinins
4. prostaglandins
5. chemotactic agents (cytokines?)

14

What is the role of histamine in the inflammatory phase? How long is it present?

1. causes early permeability increase
2.

15

What is the role of seratonin in the inflammatory phase? When does it have its effect?

1. endothelial cell swelling
2. induces lysyl oxidase that is responsible for collagen crosslinking during wound healing in the maturation/remodelling phase
3. is present later than histamine

16

What do kinins do in the inflammatory phase

increase capillary permeability

17

What do prostaglandins do in the inflammatory phase?

1. permeability changes
2. vasoactive
3. chemotaxis
4. stimulate mitosis

18

How do NSAIDs impair healing?

They prevent the production of prostaglandins, which have a role during the inflammatory phase

19

What are chemotactic agents involved in the inflammatory phase?

1. prostaglandins
2. lymph node permeability factor
3. cytokines

20

How are granulocytes pH sensitive?

when the pH drops (acidic) they dump their contents, which results in destruction of bacteria, but also destruction of tissue (collagenase, proteolytic enzyme release)

21

In models with knock out granulocytes, are there changes to wound healing? (if bacterial number is limited)

no

22

What is the role of granulocytes in a wound?

kill bacteria

23

Are macrophages necessary for wound healing?

yes

24

HOw is wound healing (inflammatory phase) localized?

1. vasodilation
2. leakage
3. lymphatics blocked (due to swelling)

25

HOw is wound healing (inflammatory phase) localized?

1. vasodilation
2. leakage
3. lymphatics blocked (due to swelling)

26

What are the 4 classic signs of inflammation?

1. redness
2. heat
3. swelling
4. pain

27

Why is pain enhanced with inflammation? Why can it have negative effects?

1. fibers upregulated with inflammation
2. can have serious negative catabolic effects

28

What is the best kind of pain control?

preemptive pain control

29

What are the 3 main roles of macrophages in the inflammatory phase of wound healing?

1. janitors--cleann
2. release mitogenic factors
3. elaborate cytokines

30

What are the steps of epithelialization in wound healing?

1. fibrin-fibronectin seal
2. epithelial migration
3. epithelial proliferation